PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane

Stable Identifier
R-HSA-1676164
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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At the plasma membrane, type I and type II inositol-3,4-bisphosphate 4-phosphatase (INPP4A) (Norris et al. 1995, Ivetac et al. 2005) and (INPP4B) (Norris et al. 1997) dephosphorylate phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2) to phosphatidylinositol 3-phosphate (PI3P).

Literature References
PubMed ID Title Journal Year
15716355 The type Ialpha inositol polyphosphate 4-phosphatase generates and terminates phosphoinositide 3-kinase signals on endosomes and the plasma membrane

Ivetac, I, Munday, AD, Kisseleva, MV, Zhang, XM, Luff, S, Tiganis, T, Whisstock, JC, Rowe, T, Majerus, PW, Mitchell, CA

Mol Biol Cell 2005
7608176 The isolation and characterization of cDNA encoding human and rat brain inositol polyphosphate 4-phosphatase

Norris, FA, Auethavekiat, V, Majerus, PW

J Biol Chem 1995
9295334 The cDNA cloning and characterization of inositol polyphosphate 4-phosphatase type II. Evidence for conserved alternative splicing in the 4-phosphatase family

Norris, FA, Atkins, RC, Majerus, PW

J Biol Chem 1997
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity of INPP4A/B [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created