Reactome | PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the early endosome membrane

PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the early endosome membrane

Stable Identifier

R-HSA-1676168

Type

Reaction [transition]

Species

Homo sapiens

Compartment

early endosome membrane, cytosol

ReviewStatus

5/5

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PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the early endosome membrane

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At the early endosome membrane, the PAS complex, consisting of FYVE finger-containing phosphoinositide kinase (PIKFYVE), yeast VAC14 homologue (VAC14), and polyphosphoinositide phosphatase aka SAC3 (FIG4), binds to the membrane via PIKFYVE's FYVE finger (Sbrissa et al. 2002, Cao et al. 2007). The PIKFYVE kinase component phosphorylates phosphatidylinositol 3-phosphate (PI3P) to phosphatidylinositol 3,5-bisphosphate PI(3,5)P2 (Sbrissa et al. 1999). The PAS complex is present in the cytosol and is recruited to the membrane (Sbrissa et al. 2007).

Literature References

PubMed ID	Title	Journal	Year
11706043	Phosphatidylinositol 3-phosphate-interacting domains in PIKfyve. Binding specificity and role in PIKfyve. Endomenbrane localization Sbrissa, D, Shisheva, A, Ikonomov, OC	J Biol Chem	2002
10419465	PIKfyve, a mammalian ortholog of yeast Fab1p lipid kinase, synthesizes 5-phosphoinositides. Effect of insulin Sbrissa, D, Shisheva, A, Ikonomov, OC	J Biol Chem	1999
17556371	Core protein machinery for mammalian phosphatidylinositol 3,5-bisphosphate synthesis and turnover that regulates the progression of endosomal transport. Novel Sac phosphatase joins the ArPIKfyve-PIKfyve complex Sbrissa, D, Ijuin, T, Gruenberg, J, Fu, Z, Shisheva, A, Takenawa, T, Ikonomov, OC	J Biol Chem	2007
17651088	Myotubularin lipid phosphatase binds the hVPS15/hVPS34 lipid kinase complex on endosomes Wandinger-Ness, A, Cao, C, Laporte, J, Stein, MP, Backer, JM	Traffic	2007

Participants

Input

Output

Participates

as an event of

Synthesis of PIPs at the early endosome membrane (Homo sapiens)

Catalyst Activity

1-phosphatidylinositol-3-phosphate 5-kinase activity of PIKFYVE:VAC14:FIG4 [early endosome membrane]

Physical Entity

PIKFYVE:VAC14:FIG4 [early endosome membrane] (Homo sapiens)

Activity

1-phosphatidylinositol-3-phosphate 5-kinase activity (GO:0000285)

Inferred From

PI3P is phosphorylated to PI(3,5)P2 by Pikfyve at the early endosome membrane (Mus musculus)

Cross References

Rhea

13609

Authored

Williams, MG (2011-10-18)

Reviewed

Wakelam, M (2012-05-14)

Created

Williams, MG (2011-10-17)

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