Reactome | PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the early endosome membrane

PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the early endosome membrane

Stable Identifier

R-HSA-1676174

Type

Reaction [transition]

Species

Homo sapiens

Compartment

early endosome membrane, cytosol

ReviewStatus

5/5

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PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the early endosome membrane

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At the early endosome membrane, the PAS complex, consisting of FYVE finger-containing phosphoinositide kinase (PIKFYVE), yeast VAC14 homologue (VAC14), and polyphosphoinositide phosphatase aka SAC3 (FIG4), binds to the membrane via PIKFYVE's FYVE finger. The FIG4 phosphatase component dephosphorylates phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) to phosphatidylinositol 3-phosphate (PI3P) (Sbrissa et al. 2007, Sbrissa et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
17556371	Core protein machinery for mammalian phosphatidylinositol 3,5-bisphosphate synthesis and turnover that regulates the progression of endosomal transport. Novel Sac phosphatase joins the ArPIKfyve-PIKfyve complex Sbrissa, D, Ijuin, T, Gruenberg, J, Fu, Z, Shisheva, A, Takenawa, T, Ikonomov, OC	J Biol Chem	2007
18950639	ArPIKfyve homomeric and heteromeric interactions scaffold PIKfyve and Sac3 in a complex to promote PIKfyve activity and functionality Sbrissa, D, Shisheva, A, Ikonomov, OC, Fenner, H	J Mol Biol	2008