PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane

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R-HSA-1676177
Type
Reaction [transition]
Species
Homo sapiens
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At the plasma membrane, Synaptojanin-1 (SYNJ1) and -2 (SYNJ2), inositol polyphosphate 5-phosphatase K (INPP5K) aka SKIP, phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (INPP5J) aka PIPP dephosphorylate phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) to form phosphatidylinositol 4-phosphate (PI4P). SYNJ1/2 both have an N-terminal Sac1-like domain, a central 5-phosphatase domain and a C-terminal proline-rich segment, with this latter part being the most divergent part of the protein sequence.

The following lists the above proteins with their corresponding literature references: SYNJ1 (Johenning et al. 2004, Haffner et al. 1997, Guo et al. 1999, Mani et al. 2007), SYNJ2 (Malecz et al. 2000), INPP5K (Injuin et al. 2000, Gurung et al. 2003), and INPP5J (Gurung et al. 2003, Mochizuki & Takenawa 1999).

Literature References
PubMed ID Title Journal Year
10753883 Identification and characterization of a novel inositol polyphosphate 5-phosphatase

Ijuin, T, Mochizuki, Y, Fukami, K, Funaki, M, Asano, T, Takenawa, T

J Biol Chem 2000
18093523 The dual phosphatase activity of synaptojanin1 is required for both efficient synaptic vesicle endocytosis and reavailability at nerve terminals

Mani, M, Lee, SY, Lucast, L, Cremona, O, Di Paolo, G, De Camilli, P, Ryan, TA

Neuron 2007
15080793 InsP3-mediated intracellular calcium signalling is altered by expression of synaptojanin-1

Johenning, FW, Wenk, MR, Uhlén, P, Degray, B, Lee, E, De Camilli, P, Ehrlich, BE

Biochem J 2004
10593988 Novel inositol polyphosphate 5-phosphatase localizes at membrane ruffles

Mochizuki, Y, Takenawa, T

J Biol Chem 1999
12536145 Identification of a novel domain in two mammalian inositol-polyphosphate 5-phosphatases that mediates membrane ruffle localization. The inositol 5-phosphatase skip localizes to the endoplasmic reticulum and translocates to membrane ruffles following epidermal growth factor stimulation

Gurung, R, Tan, A, Ooms, LM, McGrath, MJ, Huysmans, RD, Munday, AD, Prescott, M, Whisstock, JC, Mitchell, CA

J Biol Chem 2003
11084340 Synaptojanin 2, a novel Rac1 effector that regulates clathrin-mediated endocytosis

Malecz, N, McCabe, PC, Spaargaren, C, Qiu, R, Chuang, Y, Symons, M

Curr Biol 2000
10224048 SAC1-like domains of yeast SAC1, INP52, and INP53 and of human synaptojanin encode polyphosphoinositide phosphatases

Guo, S, Stolz, LE, Lemrow, SM, York, JD

J Biol Chem 1999
9428629 Synaptojanin 1: localization on coated endocytic intermediates in nerve terminals and interaction of its 170 kDa isoform with Eps15

Haffner, C, Takei, K, Chen, H, Ringstad, N, Hudson, A, Butler, MH, Salcini, AE, Di Fiore, PP, De Camilli, P

FEBS Lett 1997
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Title
phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity of SYNJ/INPP5(1) [cytosol]
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