PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane

Stable Identifier
Reaction [transition]
Homo sapiens
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At the Golgi membrane, phosphatidylinositol 4-kinase alpha (PI4KA) (Gehrmann et al. 1999, Godi et al. 1999), or phosphatidylinositol 4-kinase type 2-alpha/beta (PI4K2A/B) (Balla et al. 2002, Minogue et al. 2001, Wei et al. 2002) phosphorylate phosphatidylinositol (PI) to produce phosphatidylinositol 4-phosphate (PI4P).
Literature References
PubMed ID Title Journal Year
11279162 Cloning of a human type II phosphatidylinositol 4-kinase reveals a novel lipid kinase family

Waugh, MG, Anderson, JS, Minogue, S, dos Santos, M, Cramer, R, Hsuan, JJ, Corless, S

J Biol Chem 2001
12324459 Type II phosphatidylinositol 4-kinase beta is a cytosolic and peripheral membrane protein that is recruited to the plasma membrane and activated by Rac-GTP

Wei, YJ, Barylko, B, Yamamoto, M, Albanesi, JP, Wlodarski, P, Sun, HQ, Martínez, M, Yin, HL, Kunii, K

J Biol Chem 2002
10101268 Functional expression and characterisation of a new human phosphatidylinositol 4-kinase PI4K230

Balla, A, Gülkan, H, Herberg, FW, Gehrmann, T, Mayr, GW, Vereb, G, Heilmeyer LM, Jr, Suer, S

Biochim Biophys Acta 1999
10559940 ARF mediates recruitment of PtdIns-4-OH kinase-beta and stimulates synthesis of PtdIns(4,5)P2 on the Golgi complex

Corda, D, Luini, A, Di Tullio, G, Godi, A, Iurisci, C, Pertile, P, Meyers, R, De Matteis, MA, Marra, P

Nat Cell Biol 1999
11923287 Characterization of type II phosphatidylinositol 4-kinase isoforms reveals association of the enzymes with endosomal vesicular compartments

Balla, T, Tuymetova, G, Balla, A, Barshishat, M, Geiszt, M

J Biol Chem 2002
Catalyst Activity

1-phosphatidylinositol 4-kinase activity of PI4KA/2A/2B [cytosol]

Orthologous Events
Cross References
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