Reactome | PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane

PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane

Stable Identifier

R-HSA-1676203

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

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PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane

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At the plasma membrane, synaptojanin-1 aka Synaptic inositol-1,4,5-trisphosphate 5-phosphatase 1 (SYNJ1) (Guo et al. 1999), -2 (SYNJ2) and some myotubularins (MTMs) dephosphorylate phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) to phosphatidylinositol 5-phosphate (PI5P). The MTMs involved are: myotubularin (MTM1) (Cao et al. 2007, Tronchere et al. 2004, Schaletzky et al. 2003, Laporte et al. 2002) and myotubularin-related proteins 1 (MTMR1) (Tronchere et al. 2004), 3 (MTMR3) (Walker et al. 2001, Lorenzo et al. 2005), 6 (MTMR6) (Schaletzky et al. 2003, Choudhury et al. 2006), and 14 (MTMR14) (Tosch et al. 2006).

Literature References

PubMed ID	Title	Journal	Year
11676921	Characterization of MTMR3. an inositol lipid 3-phosphatase with novel substrate specificity Walker, DM, Urbé, S, Dove, SK, Tenza, D, Raposo, G, Clague, MJ	Curr Biol	2001
15840652	Analysis of phosphoinositide binding domain properties within the myotubularin-related protein MTMR3 Lorenzo, O, Urbé, S, Clague, MJ	J Cell Sci	2005
16914545	Specificity of the myotubularin family of phosphatidylinositol-3-phosphatase is determined by the PH/GRAM domain Choudhury, P, Srivastava, S, Li, Z, Ko, K, Albaqumi, M, Narayan, K, Coetzee, WA, Lemmon, MA, Skolnik, EY	J Biol Chem	2006
14660569	Production of phosphatidylinositol 5-phosphate by the phosphoinositide 3-phosphatase myotubularin in mammalian cells Tronchère, H, Laporte, J, Pendaries, C, Chaussade, C, Liaubet, L, Pirola, L, Mandel, JL, Payrastre, B	J Biol Chem	2004
12118066	The PtdIns3P phosphatase myotubularin is a cytoplasmic protein that also localizes to Rac1-inducible plasma membrane ruffles Laporte, J, Blondeau, F, Gansmuller, A, Lutz, Y, Vonesch, JL, Mandel, JL	J Cell Sci	2002
12646134	Phosphatidylinositol-5-phosphate activation and conserved substrate specificity of the myotubularin phosphatidylinositol 3-phosphatases Schaletzky, J, Dove, SK, Short, B, Lorenzo, O, Clague, MJ, Barr, FA	Curr Biol	2003
17651088	Myotubularin lipid phosphatase binds the hVPS15/hVPS34 lipid kinase complex on endosomes Cao, C, Laporte, J, Backer, JM, Wandinger-Ness, A, Stein, MP	Traffic	2007
10224048	SAC1-like domains of yeast SAC1, INP52, and INP53 and of human synaptojanin encode polyphosphoinositide phosphatases Guo, S, Stolz, LE, Lemrow, SM, York, JD	J Biol Chem	1999
17008356	A novel PtdIns3P and PtdIns(3,5)P2 phosphatase with an inactivating variant in centronuclear myopathy Tosch, V, Rohde, HM, Tronchère, H, Zanoteli, E, Monroy, N, Kretz, C, Dondaine, N, Payrastre, B, Mandel, JL, Laporte, J	Hum Mol Genet	2006