PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane

Stable Identifier
Reaction [transition]
Homo sapiens
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At the plasma membrane, synaptojanin-1 aka Synaptic inositol-1,4,5-trisphosphate 5-phosphatase 1 (SYNJ1) (Guo et al. 1999), -2 (SYNJ2) and some myotubularins (MTMs) dephosphorylate phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) to phosphatidylinositol 5-phosphate (PI5P). The MTMs involved are: myotubularin (MTM1) (Cao et al. 2007, Tronchere et al. 2004, Schaletzky et al. 2003, Laporte et al. 2002) and myotubularin-related proteins 1 (MTMR1) (Tronchere et al. 2004), 3 (MTMR3) (Walker et al. 2001, Lorenzo et al. 2005), 6 (MTMR6) (Schaletzky et al. 2003, Choudhury et al. 2006), and 14 (MTMR14) (Tosch et al. 2006).
Literature References
PubMed ID Title Journal Year
15840652 Analysis of phosphoinositide binding domain properties within the myotubularin-related protein MTMR3

Lorenzo, O, Clague, MJ, Urbé, S

J Cell Sci 2005
11676921 Characterization of MTMR3. an inositol lipid 3-phosphatase with novel substrate specificity

Tenza, D, Walker, DM, Clague, MJ, Urbé, S, Dove, SK, Raposo, G

Curr Biol 2001
16914545 Specificity of the myotubularin family of phosphatidylinositol-3-phosphatase is determined by the PH/GRAM domain

Albaqumi, M, Ko, K, Narayan, K, Li, Z, Srivastava, S, Skolnik, EY, Lemmon, MA, Choudhury, P, Coetzee, WA

J Biol Chem 2006
14660569 Production of phosphatidylinositol 5-phosphate by the phosphoinositide 3-phosphatase myotubularin in mammalian cells

Payrastre, B, Pendaries, C, Pirola, L, Laporte, J, Tronchère, H, Mandel, JL, Chaussade, C, Liaubet, L

J Biol Chem 2004
12118066 The PtdIns3P phosphatase myotubularin is a cytoplasmic protein that also localizes to Rac1-inducible plasma membrane ruffles

Gansmuller, A, Vonesch, JL, Laporte, J, Mandel, JL, Blondeau, F, Lutz, Y

J Cell Sci 2002
12646134 Phosphatidylinositol-5-phosphate activation and conserved substrate specificity of the myotubularin phosphatidylinositol 3-phosphatases

Lorenzo, O, Short, B, Barr, FA, Schaletzky, J, Clague, MJ, Dove, SK

Curr Biol 2003
17651088 Myotubularin lipid phosphatase binds the hVPS15/hVPS34 lipid kinase complex on endosomes

Wandinger-Ness, A, Cao, C, Laporte, J, Stein, MP, Backer, JM

Traffic 2007
10224048 SAC1-like domains of yeast SAC1, INP52, and INP53 and of human synaptojanin encode polyphosphoinositide phosphatases

Lemrow, SM, Guo, S, Stolz, LE, York, JD

J Biol Chem 1999
17008356 A novel PtdIns3P and PtdIns(3,5)P2 phosphatase with an inactivating variant in centronuclear myopathy

Payrastre, B, Tosch, V, Rohde, HM, Zanoteli, E, Laporte, J, Kretz, C, Dondaine, N, Tronchère, H, Mandel, JL, Monroy, N

Hum Mol Genet 2006
Catalyst Activity

phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity of MTM1,MTMR1,MTMR3,MTMR6,MTMR14,SYNJ1,SYNJ2 [cytosol]

Orthologous Events
Cross References
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