PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane

Stable Identifier
R-HSA-1676204
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

At the Golgi membrane, phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase (TPTE2) aka TPIP dephosphorylates phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2) to produce phosphatidylinositol 4-phosphate (PI4P) (Tapparel et al. 2000, Walker et al. 2001). The transmembrane phosphatase TPTE2 gamma isoform colocalises in the Golgi and the endoplasmic reticulum (Tapparel et al. 2000).

Literature References
PubMed ID Title Journal Year
14659893 The TPTE gene family: cellular expression, subcellular localization and alternative splicing

Tapparel, C, Reymond, A, Girardet, C, Guillou, L, Lyle, R, Lamon, C, Hutter, P, Antonarakis, SE

Gene 2003
11716755 TPIP: a novel phosphoinositide 3-phosphatase

Walker, SM, Downes, CP, Leslie, NR

Biochem J 2001
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity of TPTE2-like proteins [Golgi membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created