PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane

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R-HSA-1676206
Type
Reaction [transition]
Species
Homo sapiens
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At the early endosome membrane, phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit alpha (PIK3C2A) (Kraq et al. 2010, Arcaro et al. 2000) phosphorylates phosphatidylinositol 4-phosphate (PI4P) to phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2).

Literature References
PubMed ID Title Journal Year
21081650 PI3KC2?, a class II PI3K, is required for dynamin-independent internalization pathways

Krag, C, Malmberg, EK, Salcini, AE

J Cell Sci 2010
10805725 Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors

Arcaro, A, Zvelebil, MJ, Wallasch, C, Ullrich, A, Waterfield, MD, Domin, J

Mol Cell Biol 2000
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Catalyst Activity
Title
1-phosphatidylinositol-4-phosphate 3-kinase activity of PIK3C2A:Ca2+/Mg2+ [cytosol]
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