Reactome | PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane

PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane

Stable Identifier

R-HSA-1676206

Type

Reaction [transition]

Species

Homo sapiens

Compartment

early endosome membrane, cytosol

ReviewStatus

5/5

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PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane

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At the early endosome membrane, phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit alpha (PIK3C2A) (Kraq et al. 2010, Arcaro et al. 2000) phosphorylates phosphatidylinositol 4-phosphate (PI4P) to phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2).

Literature References

PubMed ID	Title	Journal	Year
10805725	Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors Waterfield, MD, Arcaro, A, Wallasch, C, Ullrich, A, Zvelebil, MJ, Domin, J	Mol Cell Biol	2000
21081650	PI3KC2?, a class II PI3K, is required for dynamin-independent internalization pathways Krag, C, Salcini, AE, Malmberg, EK	J Cell Sci	2010