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RANGAP1 [nuclear envelope]
Stable Identifier
R-HSA-167661
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nuclear envelope
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
M Phase (Homo sapiens)
Mitotic Metaphase and Anaphase (Homo sapiens)
Mitotic Anaphase (Homo sapiens)
Nuclear Envelope (NE) Reassembly (Homo sapiens)
Postmitotic nuclear pore complex (NPC) reformation (Homo sapiens)
UBC9 (UBE2I) SUMOylates RANGAP1 with SUMO, which targets RANGAP1 to RANBP2 (Homo sapiens)
RANGAP1 homodimer [nuclear envelope] (Homo sapiens)
RANGAP1 [nuclear envelope] (Homo sapiens)
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
HIV Infection (Homo sapiens)
HIV Life Cycle (Homo sapiens)
Late Phase of HIV Life Cycle (Homo sapiens)
Rev-mediated nuclear export of HIV RNA (Homo sapiens)
Hydrolysis of Ran:GTP to Ran:GDP (Homo sapiens)
RANGAP1 [nuclear envelope] (Homo sapiens)
Host Interactions of HIV factors (Homo sapiens)
Interactions of Rev with host cellular proteins (Homo sapiens)
Rev-mediated nuclear export of HIV RNA (Homo sapiens)
Hydrolysis of Ran:GTP to Ran:GDP (Homo sapiens)
RANGAP1 [nuclear envelope] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
UBC9 (UBE2I) SUMOylates RANGAP1 with SUMO, which targets RANGAP1 to RANBP2 (Homo sapiens)
RANGAP1 homodimer [nuclear envelope] (Homo sapiens)
RANGAP1 [nuclear envelope] (Homo sapiens)
External Reference Information
External Reference
UniProt:P46060 RANGAP1
Gene Names
RANGAP1, KIAA1835, SD
Chain
initiator methionine:1, chain:2-587
Reference Genes
BioGPS Gene:5905 RANGAP1
COSMIC (genes):RANGAP1 RANGAP1
CTD Gene:5905 RANGAP1
dbSNP Gene:5905 RANGAP1
ENSEMBL:ENSG00000100401 RANGAP1
HGNC:9854 RANGAP1
KEGG Gene (Homo sapiens):5905 RANGAP1
Monarch:5905 RANGAP1
NCBI Gene:5905 RANGAP1
OMIM:602362 RANGAP1
UCSC:P46060 RANGAP1
Reference Transcript
RefSeq:XM_017028893.1 RANGAP1
RefSeq:XM_017028894.1 RANGAP1
RefSeq:NM_001278651.1 RANGAP1
RefSeq:XM_006724289.3 RANGAP1
RefSeq:XM_011530295.2 RANGAP1
RefSeq:XM_017028895.1 RANGAP1
RefSeq:NM_001317930.1 RANGAP1
RefSeq:XM_011530294.2 RANGAP1
RefSeq:XM_017028896.1 RANGAP1
RefSeq:XM_017028897.1 RANGAP1
RefSeq:NM_002883.3 RANGAP1
Other Identifiers
0005340739
11717164_a_at
11717165_a_at
1553535_a_at
16935396
212125_at
212127_at
32151_at
3961843
3961844
3961845
3961846
3961847
3961848
3961851
3961852
3961855
3961857
3961858
3961859
3961860
3961862
3961864
3961865
3961869
3961872
3961873
3961874
3961876
3961877
3961878
3961879
3961880
3961881
3961883
3961885
3961886
3961887
3961888
3961889
5905
8076307
A_23_P333420
A_33_P3263307
GE62508
GO:0000278
GO:0000775
GO:0000776
GO:0000777
GO:0003674
GO:0003723
GO:0005096
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005635
GO:0005643
GO:0005654
GO:0005694
GO:0005737
GO:0005819
GO:0005829
GO:0005856
GO:0006464
GO:0006810
GO:0006913
GO:0006950
GO:0007010
GO:0007049
GO:0007052
GO:0007084
GO:0007165
GO:0008150
GO:0015031
GO:0016235
GO:0016925
GO:0019899
GO:0030234
GO:0030425
GO:0031267
GO:0031625
GO:0031965
GO:0032991
GO:0043226
GO:0043231
GO:0043547
GO:0044614
GO:0045296
GO:0046826
GO:0048471
GO:0048678
GO:0061024
GO:0071375
GO:0072686
GO:0090630
GO:0140014
GO:1904115
GO:1904117
GO:1990723
HMNXSV003050468
Hs.183800.0.S1_3p_at
Hs.183800.0.S2_3p_at
Hs2.183800.1.S1_3p_s_at
ILMN_1662198
PH_hs_0029369
TC22000823.hg
Participates
as a component of
RANGAP1 homodimer [nuclear envelope] (Homo sapiens)
This entity regulates
Positively
Hydrolysis of Ran:GTP to Ran:GDP
(Homo sapiens)
Other forms of this molecule
SUMO1-K524-RANGAP1 [nuclear envelope]
RANGAP1 [cytosol]
Inferred To
RanGAP [nuclear envelope]
(Drosophila melanogaster)
rna1 [nuclear envelope]
(Schizosaccharomyces pombe)
Rangap1 [nuclear envelope]
(Mus musculus)
Rangap1 [nuclear envelope]
(Rattus norvegicus)
ran-2 [nuclear envelope]
(Caenorhabditis elegans)
rangap1 [nuclear envelope]
(Xenopus tropicalis)
RANGAP1 [nuclear envelope]
(Canis familiaris)
RANGAP1 [nuclear envelope]
(Dictyostelium discoideum)
RANGAP1 [nuclear envelope]
(Gallus gallus)
RANGAP1 [nuclear envelope]
(Sus scrofa)
rangap1a [nuclear envelope]
(Danio rerio)
RNA1 [nuclear envelope]
(Saccharomyces cerevisiae)
Cross References
RefSeq
XP_011528597.1
,
NP_002874.1
,
XP_016884383.1
,
XP_016884385.1
,
XP_011528596.1
,
NP_001304859.1
,
XP_006724352.1
,
XP_016884382.1
,
XP_016884384.1
,
XP_016884386.1
,
NP_001265580.1
OpenTargets
ENSG00000100401
GeneCards
P46060
HPA
ENSG00000100401-RANGAP1
Ensembl
ENST00000405486
,
ENST00000356244
,
ENSP00000385866
,
ENSP00000348577
,
ENST00000455915
,
ENSG00000100401
,
ENSP00000401470
PRO
P46060
Pharos - Targets
P46060
GlyGen
P46060
Orphanet
24848
PDB
5D2M
,
2GRQ
,
2GRP
,
3UIP
,
3UIN
,
2GRO
,
2GRR
,
2IY0
,
2GRN
,
2IO3
,
2IO2
,
1Z5S
,
3UIO
Interactors (11)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P63165 SUMO1
20
K676-TRIM28-G97-SUMO1 [nucleoplasm]
(R-HSA-4090396)
ING2-G97-SUMO1 [nucleoplasm]
(R-HSA-4086096)
K554-TRIM28-G97-SUMO1 [nucleoplasm]
(R-HSA-3782555)
K2592-RANBP2-G97-SUMO1 [nuclear envelope]
(R-HSA-4551627)
K804-TRIM28-G97-SUMO1 [nucleoplasm]
(R-HSA-3782561)
K2723-RANBP2-G97-SUMO1 [nuclear envelope]
(R-HSA-4551737)
K750-TRIM28-G97-SUMO1 [nucleoplasm]
(R-HSA-4090298)
TOPORS-G97-SUMO1 [nucleoplasm]
(R-HSA-4551623)
K2650-RANBP2-G97-SUMO1 [nuclear envelope]
(R-HSA-4551591)
K788-Ncoa2-G97-SUMO1 [nucleoplasm]
(R-HSA-4085297)
K731-Ncoa2-G97-SUMO1 [nucleoplasm]
(R-HSA-4085312)
K779-TRIM28-G97-SUMO1 [nucleoplasm]
(R-HSA-3782585)
K171-VHL-G97-SUMO1 [nucleoplasm]
(R-HSA-4551632)
K239-Ncoa2-G97-SUMO1 [nucleoplasm]
(R-HSA-4085320)
PIAS4-G97-SUMO1 [nucleoplasm]
(R-HSA-3968375)
K196-VHL-G97-SUMO1 [nucleoplasm]
(R-HSA-4551630)
K14-UBE2I-G97-SUMO1 [nucleoplasm]
(R-HSA-4085334)
K159-VHL-G97-SUMO1 [nucleoplasm]
(R-HSA-4551713)
MDM-G97-SUMO1 [nucleoplasm]
(R-HSA-3730829)
K575-TRIM28-G97-SUMO1 [nucleoplasm]
(R-HSA-4090305)
0.962
14
UniProt:P63279 UBE2I
8
SUMO1-K14-UBE2I [nucleoplasm]
(R-HSA-4085358)
SUMO2-C93-UBE2I [nucleoplasm]
(R-HSA-3730619)
SUMO1-C93-UBE2I [nucleoplasm]
(R-HSA-3730617)
SUMO1-C93-UBE2I [cytosol]
(R-HSA-4656909)
UBE2I [nuclear envelope]
(R-HSA-4655408)
UBE2I [cytosol]
(R-HSA-4655342)
SUMO3-C93-UBE2I [nucleoplasm]
(R-HSA-3730629)
UBE2I [nucleoplasm]
(R-HSA-912481)
0.946
13
UniProt:P61956 SUMO2
5
SUMO2(1-95) [nucleoplasm]
(R-HSA-2990837)
MDC1-SUMO2 [nucleoplasm]
(R-HSA-5684062)
SUMO2 [nucleoplasm]
(R-HSA-2984281)
UBE2I-G93-SUMO2 [nucleoplasm]
(R-HSA-3730625)
UBA2-G93-SUMO2 [nucleoplasm]
(R-HSA-3730618)
0.75
6
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.666
10
UniProt:P49792 RANBP2
6
RANBP2(1-867)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9702002)
RANBP2 [nuclear envelope]
(R-HSA-2993756)
RANBP2(1-867)-p-7Y ALK(1058-1620) fusion [cytosol]
(R-HSA-9718443)
RANBP2 [cytosol]
(R-HSA-157703)
SUMO2-K2652,K2725-RANBP2 [nuclear envelope]
(R-HSA-4551720)
SUMO1-K2592,K2650,K2723-RANBP2 [nuclear envelope]
(R-HSA-4551599)
0.623
4
UniProt:Q9P0U3 SENP1
2
SENP1 [cytosol]
(R-HSA-9715128)
SENP1 [nucleoplasm]
(R-HSA-2984299)
0.591
4
UniProt:Q9HC62 SENP2
1
SENP2 [nucleoplasm]
(R-HSA-2984298)
0.591
6
UniProt:Q9ERU9 Ranbp2
5
Ranbp2 [nuclear envelope]
(R-MMU-4551599)
Ranbp2 [nuclear envelope]
(R-MMU-4551720)
Ranbp2 [nuclear envelope]
(R-MMU-2993756)
Ranbp2 [nuclear envelope]
(R-MMU-5228524)
Ranbp2 [cytosol]
(R-MMU-157703)
0.564
2
IntAct:EBI-25865403 EHD27213144
0.556
3
UniProt:Q9UBU9 NXF1
2
NXF1 [cytosol]
(R-HSA-156481)
NXF1 [nucleoplasm]
(R-HSA-111690)
0.527
2
UniProt:P05412 JUN
4
p-S63,S73-JUN [nucleoplasm]
(R-HSA-450237)
JUN [cytosol]
(R-HSA-168194)
JUN [nucleoplasm]
(R-HSA-450250)
p-S63,S73-JUN [cytosol]
(R-HSA-8868682)
0.462
2
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