Reactome | AP1M1 [cytosol]

AP1M1 [cytosol]

Stable Identifier

R-HSA-167700

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

AP-1 mu 1

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - HIV Infection (Homo sapiens)
      - Host Interactions of HIV factors (Homo sapiens)
        
        The role of Nef in HIV-1 replication and disease pathogenesis (Homo sapiens)
        
        Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters (Homo sapiens)
        
        Nef mediated downregulation of MHC class I complex cell surface expression (Homo sapiens)
        
        Degradation of MHC I Complex (Homo sapiens)
        
        AP-1 Complex [cytosol] (Homo sapiens)
        
        AP-1 mu [cytosol] (Homo sapiens)
        
        AP1M1 [cytosol] (Homo sapiens)
        
        Nef:class I MHC complex:AP-1:PACS-1 Complex [early endosome membrane] (Homo sapiens)
        
        AP-1 Complex [cytosol] (Homo sapiens)
        
        AP-1 mu [cytosol] (Homo sapiens)
        
        AP1M1 [cytosol] (Homo sapiens)
        
        Formation of MHC I:Nef:AP-1:PACS-1 Complex (Homo sapiens)
        
        AP-1 Complex [cytosol] (Homo sapiens)
        
        AP-1 mu [cytosol] (Homo sapiens)
        
        AP1M1 [cytosol] (Homo sapiens)
        
        Nef:class I MHC complex:Ap-1:PACS-1 Complex [Golgi membrane] (Homo sapiens)
        
        AP-1 Complex [cytosol] (Homo sapiens)
        
        AP-1 mu [cytosol] (Homo sapiens)
        
        AP1M1 [cytosol] (Homo sapiens)
        
        Transport of MHC I:Nef:AP-1:PACS-1 Complex (Homo sapiens)
        
        Nef:class I MHC complex:AP-1:PACS-1 Complex [early endosome membrane] (Homo sapiens)
        
        AP-1 Complex [cytosol] (Homo sapiens)
        
        AP-1 mu [cytosol] (Homo sapiens)
        
        AP1M1 [cytosol] (Homo sapiens)
        
        Nef:class I MHC complex:Ap-1:PACS-1 Complex [Golgi membrane] (Homo sapiens)
        
        AP-1 Complex [cytosol] (Homo sapiens)
        
        AP-1 mu [cytosol] (Homo sapiens)
        
        AP1M1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9BXS5 AP1M1

Gene Names

AP1M1, CLTNM

Chain

initiator methionine:, chain:2-423

Reference Genes

BioGPS Gene:8907 AP1M1

COSMIC (genes):AP1M1 AP1M1

CTD Gene:8907 AP1M1

dbSNP Gene:8907 AP1M1

ENSEMBL:ENSG00000072958 AP1M1

HGNC:13667 AP1M1

KEGG:hsa:8907 AP1M1

Monarch:8907 AP1M1

NCBI Gene:8907 AP1M1

OMIM:603535 AP1M1

UCSC:Q9BXS5 AP1M1

Reference Transcript

Other Identifiers

11715762_s_at

11747500_a_at

16859300

223024_PM_at

223024_at

223025_PM_s_at

223025_s_at

2610786

3251363

3571426

3823626

3823627

3823628

3823632

3823636

3823637

3823638

3823639

3823640

3823641

3823642

3823643

3823644

3823648

3823649

3823650

3823651

3823654

3823655

3823656

3823657

3823659

3823660

3823661

3823662

3823663

3823664

3823665

45767_at

8026548

8907

A_14_P106114

A_14_P112660

A_23_P55802

GE86671

GO:0000139

GO:0005515

GO:0005737

GO:0005765

GO:0005768

GO:0005769

GO:0005794

GO:0005829

GO:0005886

GO:0006886

GO:0015031

GO:0016020

GO:0016192

GO:0030121

GO:0030131

GO:0030136

GO:0030659

GO:0030665

GO:0031410

GO:0032438

GO:0032588

GO:0035579

GO:0035615

GO:0035646

GO:0043226

GO:0043231

GO:0045202

GO:0060090

GO:0060155

GO:0070062

GO:1903232

HMNXSV003004687

ILMN_1754738

PH_hs_0004130

TC19000320.hg

g13491973_3p_a_at

Participates

as a member of

AP-1 mu [cytosol] (Homo sapiens)

Other forms of this molecule

AP1M1 [cytoplasmic vesicle membrane]

AP1M1 [Golgi membrane]

AP1M1 [lysosomal membrane]

AP1M1 [trans-Golgi network membrane]

AP1M1 [plasma membrane]

AP1M1 [specific granule membrane]

Inferred To

AP-1mu [cytosol] (Drosophila melanogaster)

unc-101 [cytosol] (Caenorhabditis elegans)

AP1M1 [cytosol] (Bos taurus)

AP1M1 [cytosol] (Canis familiaris)

AP1M1 [cytosol] (Gallus gallus)

AP1M1 [cytosol] (Plasmodium falciparum)

AP1M1 [cytosol] (Sus scrofa)

Ap1m1 [cytosol] (Mus musculus)

Ap1m1 [cytosol] (Rattus norvegicus)

ap1m1 [cytosol] (Xenopus tropicalis)

apm1 [cytosol] (Dictyostelium discoideum)

apm1 [cytosol] (Schizosaccharomyces pombe)

APM1 [cytosol] (Saccharomyces cerevisiae)

Cross References

ENSEMBL

ENST00000444449, ENST00000291439, ENSP00000388996, ENSP00000291439

OpenTargets

ENSG00000072958

HPA

ENSG00000072958-AP1M1

PRO

Q9BXS5

Pharos - Targets

Q9BXS5

GlyGen

Q9BXS5

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9UGI0 ZRANB1	1	ZRANB1 [cytosol] (R-HSA-6781939)	0.556	3
UniProt:P18848 ATF4	2	ATF4 [cytosol] (R-HSA-381084) ATF4 [nucleoplasm] (R-HSA-381016)	0.556	3
UniProt:P26367 PAX6	1	PAX6 [nucleoplasm] (R-HSA-3009044)	0.556	3
UniProt:P14373 TRIM27	2	TRIM27 [cytosol] (R-HSA-8851002) TRIM27 [nucleoplasm] (R-HSA-2997690)	0.556	3
UniProt:Q9NRD5 PICK1	2	PICK1 [plasma membrane] (R-HSA-416989) PICK1 [endocytic vesicle membrane] (R-HSA-417017)	0.556	3
UniProt:P21741 MDK	1	MDK [extracellular region] (R-HSA-2160953)	0.556	3
UniProt:Q8N5F7 NKAP	1	NKAP [nucleoplasm] (R-HSA-9769602)	0.556	3
UniProt:Q9Y2T1 AXIN2	4	AXIN2 [cytosol] (R-HSA-3640821) ub-AXIN2 [cytosol] (R-HSA-4641131) RibC-AXIN2 [cytosol] (R-HSA-3640842) Ub-RibC-AXIN2 [cytosol] (R-HSA-3640859)	0.556	3
UniProt:Q9UBB9 TFIP11	1	TFIP11 [nucleoplasm] (R-HSA-8869310)	0.556	3
UniProt:Q9HBZ2 ARNT2	1	ARNT2 [nucleoplasm] (R-HSA-8936838)	0.556	3
UniProt:P04578 env	7	ENV [viral envelope] (R-HIV-173439) Surface protein gp120 [viral envelope] (R-HIV-171211) Transmembrane protein gp41 [viral envelope] (R-HIV-171195) Envelope glycoprotein gp160 [endoplasmic reticulum membrane] (R-HIV-189343) Glycosylated Envelope glycoprotein gp160 [Golgi membrane] (R-HIV-3149443) Transmembrane protein gp41 (P04578) [cytosol] (R-HIV-189359) Surface protein gp120 (P04578) [cytosol] (R-HIV-189269)	0.462	2