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ARIH1 [cytosol]
Stable Identifier
R-HSA-1678825
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
E3 ubiquitin-protein ligase ARIH1, ARI1_HUMAN
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
Respiratory Syncytial Virus Infection Pathway (Homo sapiens)
RSV-host interactions (Homo sapiens)
ISGylation of BECN1 (Homo sapiens)
ISG15 E3 ligases [cytosol] (Homo sapiens)
ARIH1 [cytosol] (Homo sapiens)
ISG15:UBCH8:ISG15 E3 ligase [cytosol] (Homo sapiens)
ISG15 E3 ligases [cytosol] (Homo sapiens)
ARIH1 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Interferon Signaling (Homo sapiens)
Antiviral mechanism by IFN-stimulated genes (Homo sapiens)
ISG15 antiviral mechanism (Homo sapiens)
Competitive inhibition of translation initiation by ISGylated 4EHP (Homo sapiens)
ISGylated 4EHP [cytosol] (Homo sapiens)
ISG15:UBCH8:ISG15 E3 ligase [cytosol] (Homo sapiens)
ISG15 E3 ligases [cytosol] (Homo sapiens)
ARIH1 [cytosol] (Homo sapiens)
ISGylated 4EHP:mRNA [cytosol] (Homo sapiens)
ISGylated 4EHP [cytosol] (Homo sapiens)
ISG15:UBCH8:ISG15 E3 ligase [cytosol] (Homo sapiens)
ISG15 E3 ligases [cytosol] (Homo sapiens)
ARIH1 [cytosol] (Homo sapiens)
ISGylation of E2 conjugating enzymes (Homo sapiens)
ISG15 E3 ligases [cytosol] (Homo sapiens)
ARIH1 [cytosol] (Homo sapiens)
ISG15:UBCH8:ISG15 E3 ligase [cytosol] (Homo sapiens)
ISG15 E3 ligases [cytosol] (Homo sapiens)
ARIH1 [cytosol] (Homo sapiens)
ISGylation of IRF3 (Homo sapiens)
ISG15 E3 ligases [cytosol] (Homo sapiens)
ARIH1 [cytosol] (Homo sapiens)
ISG15:UBCH8:ISG15 E3 ligase [cytosol] (Homo sapiens)
ISG15 E3 ligases [cytosol] (Homo sapiens)
ARIH1 [cytosol] (Homo sapiens)
ISGylation of host protein filamin B (Homo sapiens)
ISG15 E3 ligases [cytosol] (Homo sapiens)
ARIH1 [cytosol] (Homo sapiens)
ISG15:UBCH8:ISG15 E3 ligase [cytosol] (Homo sapiens)
ISG15 E3 ligases [cytosol] (Homo sapiens)
ARIH1 [cytosol] (Homo sapiens)
ISGylation of host proteins (Homo sapiens)
ISG15 E3 ligases [cytosol] (Homo sapiens)
ARIH1 [cytosol] (Homo sapiens)
ISG15:UBCH8:ISG15 E3 ligase [cytosol] (Homo sapiens)
ISG15 E3 ligases [cytosol] (Homo sapiens)
ARIH1 [cytosol] (Homo sapiens)
ISGylation of protein phosphatase 1 beta (PP2CB) (Homo sapiens)
ISG15 E3 ligases [cytosol] (Homo sapiens)
ARIH1 [cytosol] (Homo sapiens)
ISG15:UBCH8:ISG15 E3 ligase [cytosol] (Homo sapiens)
ISG15 E3 ligases [cytosol] (Homo sapiens)
ARIH1 [cytosol] (Homo sapiens)
ISGylation of protein translation regulator 4EHP (Homo sapiens)
ISG15:UBCH8:ISG15 E3 ligase [cytosol] (Homo sapiens)
ISG15 E3 ligases [cytosol] (Homo sapiens)
ARIH1 [cytosol] (Homo sapiens)
ISGylated 4EHP [cytosol] (Homo sapiens)
ISG15:UBCH8:ISG15 E3 ligase [cytosol] (Homo sapiens)
ISG15 E3 ligases [cytosol] (Homo sapiens)
ARIH1 [cytosol] (Homo sapiens)
ISGylation of viral protein NS1 (Homo sapiens)
ISG15 E3 ligases [cytosol] (Homo sapiens)
ARIH1 [cytosol] (Homo sapiens)
ISG15:UBCH8:ISG15 E3 ligase [cytosol] (Homo sapiens)
ISG15 E3 ligases [cytosol] (Homo sapiens)
ARIH1 [cytosol] (Homo sapiens)
Interaction of E3 ligase with ISG15:E2 complex (Homo sapiens)
ISG15 E3 ligases [cytosol] (Homo sapiens)
ARIH1 [cytosol] (Homo sapiens)
ISG15:UBCH8:ISG15 E3 ligase [cytosol] (Homo sapiens)
ISG15 E3 ligases [cytosol] (Homo sapiens)
ARIH1 [cytosol] (Homo sapiens)
PKR-mediated signaling (Homo sapiens)
ISGylation of PKR (Homo sapiens)
ISG15 E3 ligases [cytosol] (Homo sapiens)
ARIH1 [cytosol] (Homo sapiens)
ISG15:UBCH8:ISG15 E3 ligase [cytosol] (Homo sapiens)
ISG15 E3 ligases [cytosol] (Homo sapiens)
ARIH1 [cytosol] (Homo sapiens)
Modulation of host responses by IFN-stimulated genes (Homo sapiens)
ISGylation of DDX58 (RIG-I) (Homo sapiens)
ISG15 E3 ligases [cytosol] (Homo sapiens)
ARIH1 [cytosol] (Homo sapiens)
UBE2L6:ISG15 E3 ligases [cytosol] (Homo sapiens)
ISG15 E3 ligases [cytosol] (Homo sapiens)
ARIH1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9Y4X5 ARIH1
Gene Names
ARIH1, ARI, MOP6, UBCH7BP, HUSSY-27
Chain
chain:1-557
Reference Genes
BioGPS Gene:25820 ARIH1
COSMIC (genes):ARIH1 ARIH1
CTD Gene:25820 ARIH1
dbSNP Gene:25820 ARIH1
ENSEMBL:ENSG00000166233 ARIH1
HGNC:689 ARIH1
KEGG:hsa:25820 ARIH1
Monarch:25820 ARIH1
NCBI Gene:25820 ARIH1
OMIM:605624 ARIH1
UCSC:Q9Y4X5 ARIH1
Reference Transcript
RefSeq:NM_005744.3 ARIH1
Other Identifiers
11717697_at
11717698_a_at
11758786_at
1556846_PM_at
1556846_at
1556847_PM_s_at
1556847_s_at
1558401_PM_at
1558401_at
16802720
17118960
201878_PM_at
201878_at
201879_PM_at
201879_at
201880_PM_at
201880_at
201881_PM_s_at
201881_s_at
241658_PM_at
241658_at
25820
3226484
3583049
3583819
3583821
3584024
3585578
3586182
3586183
3586186
3586224
3586225
3586228
3586232
3586511
3586512
3586582
3586583
3586737
3587408
3587411
3587414
3600745
3600746
3600747
3600748
3600749
3600761
3600770
3600783
3600785
3600786
3600788
3600790
3600791
3600792
3600793
3600797
3600799
3600803
3600804
3600805
3600806
3600807
3600808
3600809
3600810
3600811
3600812
3600813
3600814
3600828
3600829
3600831
3600833
3600834
3600836
3600838
3600840
3600842
3600844
3600845
3600847
3600849
3600851
3600853
3600855
3600856
3600858
3600860
3600861
3600863
3600865
3600867
3600869
3600870
3600872
3600873
3600875
3600876
3600877
3600878
3600879
3600880
3600881
3600882
3600883
3600926
3600930
3600931
3600933
3600943
3602164
3602167
3602168
3602169
3602179
3602180
3602203
3602204
3602205
3602214
3602248
3602453
3602456
3603497
3603500
3603502
3603508
3603525
3605010
3605677
3613214
3615213
3615338
3615339
3615848
3615849
3616534
3616537
3616598
3616601
3616602
3617494
3617496
3617610
3617611
3628185
3632706
3632707
3632717
3632719
3632723
3634379
3634380
3634394
3635917
3636133
3636752
3637161
3642491
3642493
3642494
4032322
4037013
4038663
4038730
4038774
4038900
4038987
41729_at
42748_at
43789_r_at
46948_at
58902_r_at
63176_at
63928_at
63929_g_at
7984641
7984660
A_14_P108502
A_23_P205855
A_24_P85478
GE61150
GE81552
GO:0000151
GO:0000209
GO:0003824
GO:0004842
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006511
GO:0008270
GO:0015030
GO:0016567
GO:0016604
GO:0016740
GO:0019005
GO:0019787
GO:0031462
GO:0031463
GO:0031464
GO:0031624
GO:0031625
GO:0039585
GO:0043226
GO:0046872
GO:0061630
GO:0097413
GO:0140096
HMNXSV003010334
HMNXSV003016446
HMNXSV003022184
HMNXSV003052487
Hs.181461.0.S2_3p_at
Hs.181461.0.S3_3p_at
Hs.181461.0.S4_3p_at
Hs.250349.0.S1_3p_at
Hs2.156027.1.A1_3p_at
Hs2.156027.1.A1_3p_s_at
Hs2.163832.1.S1_3p_at
ILMN_1694219
ILMN_1776275
PH_hs_0010737
TC15000659.hg
TC15000660.hg
TC15002267.hg
TC15002268.hg
g9966762_3p_a_at
p5649
p5650
Participates
as a member of
ISG15 E3 ligases [cytosol] (Homo sapiens)
Inferred To
ARIH1 [cytosol]
(Bos taurus)
ARIH1 [cytosol]
(Caenorhabditis elegans)
ARIH1 [cytosol]
(Canis familiaris)
ARIH1 [cytosol]
(Danio rerio)
ARIH1 [cytosol]
(Dictyostelium discoideum)
ARIH1 [cytosol]
(Drosophila melanogaster)
ARIH1 [cytosol]
(Gallus gallus)
ARIH1 [cytosol]
(Mus musculus)
ARIH1 [cytosol]
(Plasmodium falciparum)
ARIH1 [cytosol]
(Sus scrofa)
ARIH1 [cytosol]
(Xenopus tropicalis)
Arih1 [cytosol]
(Rattus norvegicus)
Cross References
RefSeq
NP_005735.2
ENSEMBL
ENST00000379887
,
ENSP00000369217
OpenTargets
ENSG00000166233
HPA
ENSG00000166233-ARIH1
PRO
Q9Y4X5
Pharos - Targets
Q9Y4X5
GlyGen
Q9Y4X5
PDB
7B5S
,
5UDH
,
1WD2
,
7B5N
,
4KC9
,
2M9Y
,
5TTE
,
4KBL
,
7B5L
,
7B5M
Interactors (14)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13616 CUL1
3
CUL1 [cytosol]
(R-HSA-174230)
CUL1 [nucleoplasm]
(R-HSA-187551)
G76-NEDD8-K720-CUL1 [cytosol]
(R-HSA-8952519)
0.773
9
UniProt:P05412 JUN
4
JUN [nucleoplasm]
(R-HSA-450250)
p-S63,S73-JUN [nucleoplasm]
(R-HSA-450237)
JUN [cytosol]
(R-HSA-168194)
p-S63,S73-JUN [cytosol]
(R-HSA-8868682)
0.643
4
UniProt:P68036 UBE2L3
4
Ub-C86-UBE2L3 [cytosol]
(R-HSA-8864201)
UBE2L3 [cytosol]
(R-HSA-947631)
UBE2L3 [nucleoplasm]
(R-HSA-8852056)
Ub-C86-UBE2L3 [nucleoplasm]
(R-HSA-8864226)
0.643
7
UniProt:P21580 TNFAIP3
1
TNFAIP3 [cytosol]
(R-HSA-688989)
0.527
2
UniProt:Q9UKA1 FBXL5
1
FBXL5 [cytosol]
(R-HSA-391295)
0.527
2
UniProt:P15336 ATF2
2
p-T69,T71-ATF2 [nucleoplasm]
(R-HSA-450243)
ATF2 [nucleoplasm]
(R-HSA-450336)
0.527
2
UniProt:P61371 ISL1
1
ISL1 [nucleoplasm]
(R-HSA-400478)
0.527
2
UniProt:P17275 JUNB
1
JUNB [nucleoplasm]
(R-HSA-2186795)
0.527
2
UniProt:Q00978 IRF9
2
IRF9 [nucleoplasm]
(R-HSA-913522)
IRF9 [cytosol]
(R-HSA-879183)
0.527
2
UniProt:Q9BYZ6 RHOBTB2
1
RHOBTB2 [endosome membrane]
(R-HSA-194907)
0.527
2
UniProt:P18846 ATF1
2
ATF1 [nucleoplasm]
(R-HSA-199900)
p-S63-ATF1 [nucleoplasm]
(R-HSA-199897)
0.527
2
UniProt:Q9BQ90 KLHDC3
1
KLHDC3 [cytosol]
(R-HSA-535552)
0.527
2
UniProt:Q96T88 UHRF1
2
UHRF1 [nucleoplasm]
(R-HSA-212103)
UHRF1 [cytosol]
(R-HSA-9818452)
0.527
2
UniProt:O75386 TULP3
1
TULP3 [cilium]
(R-HSA-5610445)
0.527
2
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