Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18

Stable Identifier
R-HSA-1678841
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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Ubiquitin specific protease 18 (USP18/UBP43) is the major ISG15 deconjugating enzyme. It removes ISG15 from ISGylated proteins. ISG15-specific protease activity of this enzyme is crucial for proper cellular balance of ISG15-conjugated proteins. However, it is not required for processing pre-ISG15 to the mature form. Furthermore, USP18 inhibits type I interferon signaling independent of its ISG15 deconjugating enzyme activity. Several viral proteins were also reported with de-ISGylation activity.

Literature References
PubMed ID Title Journal Year
11788588 UBP43 (USP18) specifically removes ISG15 from conjugated proteins

Malakhov, MP, Malakhova, OA, Kim, KI, Ritchie, KJ, Zhang, DE

J Biol Chem 2002
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
ISG15-specific protease activity of USP18-like proteins [cytosol]
Physical Entity
Activity
Orthologous Events
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Created