ISGylation of protein translation regulator 4EHP

Stable Identifier
R-HSA-1678843
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
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ISGylation of protein translation regulator 4EHP
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4EHP is a member of eukaryotic translation initiation factor 4E (eIF4E) family that acts as an mRNA 5' cap structure-binding protein and suppresses translation. 4EHP is one of the targets of ISG15 and ISGylated 4EHP has a much higher cap structure-binding activity.

Literature References
PubMed ID Title Journal Year
17289916 ISG15 modification of the eIF4E cognate 4EHP enhances cap structure-binding activity of 4EHP

Okumura, F, Zou, W, Zhang, DE

Genes Dev 2007
Participants
Input
Output
Participant Of
hasEvent
Orthologous Events
ISGylation of protein translation regulator 4EHP (Bos taurus)
ISGylation of protein translation regulator 4EHP (Canis familiaris)
ISGylation of protein translation regulator 4EHP (Danio rerio)
ISGylation of protein translation regulator 4EHP (Dictyostelium discoideum)
ISGylation of protein translation regulator 4EHP (Drosophila melanogaster)
ISGylation of protein translation regulator 4EHP (Mus musculus)
ISGylation of protein translation regulator 4EHP (Rattus norvegicus)
ISGylation of protein translation regulator 4EHP (Sus scrofa)
ISGylation of protein translation regulator 4EHP (Xenopus tropicalis)
Authored
Garapati, P V  (2011-01-18)
Reviewed
Zhang, DE  (2011-02-11)
Created
Garapati, P V  (2011-10-19)
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