ISGylation of protein translation regulator 4EHP

Stable Identifier
R-HSA-1678843
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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4EHP is a member of eukaryotic translation initiation factor 4E (eIF4E) family that acts as an mRNA 5' cap structure-binding protein and suppresses translation. 4EHP is one of the targets of ISG15 and ISGylated 4EHP has a much higher cap structure-binding activity.

Literature References
PubMed ID Title Journal Year
17289916 ISG15 modification of the eIF4E cognate 4EHP enhances cap structure-binding activity of 4EHP

Okumura, F, Zou, W, Zhang, DE

Genes Dev 2007
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created