Reactome | GUSB [lysosomal lumen]

GUSB [lysosomal lumen]

Stable Identifier

R-HSA-1678846

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

lysosomal lumen

Synonyms

Beta-glucuronidase, BGLR_HUMAN

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External Reference Information

External Reference

UniProt:P08236 GUSB

Gene Names

GUSB

Chain

signal peptide:1-22, chain:23-651

Reference Genes

BioGPS Gene:2990 GUSB

COSMIC (genes):GUSB GUSB

CTD Gene:2990 GUSB

dbSNP Gene:2990 GUSB

ENSEMBL:ENSG00000169919 GUSB

HGNC:4696 GUSB

KEGG:hsa:2990 GUSB

Monarch:2990 GUSB

NCBI Gene:2990 GUSB

OMIM:611499 GUSB

UCSC:P08236 GUSB

Reference Transcript

Other Identifiers

11719271_s_at

17058176

202605_PM_at

202605_at

2868809

2990

3004396

3053693

3053694

3053695

3053696

3053697

3053698

3053699

3053700

3053701

3053702

3053703

3053704

3053705

3053706

3053707

3053709

3053711

3053712

3053713

3053714

3053715

3053716

3053717

3053718

3053719

3053720

3053721

3053722

3053723

3053724

3053725

3053728

3053729

33308_at

8139859

A_23_P334608

GE61184

GO:0003824

GO:0004553

GO:0004566

GO:0005102

GO:0005576

GO:0005615

GO:0005764

GO:0005773

GO:0005975

GO:0006027

GO:0006790

GO:0016020

GO:0016787

GO:0016798

GO:0019391

GO:0019904

GO:0030163

GO:0030200

GO:0030207

GO:0030214

GO:0030246

GO:0035578

GO:0043202

GO:0043226

GO:0043231

GO:0070062

GO:1901135

GO:1904813

HMNXSV003041271

ILMN_1669878

M15182_at

PH_hs_0023271

PH_hs_0032345

TC07001457.hg

g4504222_3p_at

Participates

as a component of

GUSB tetramer [lysosomal lumen] (Homo sapiens)

Other forms of this molecule

GUSB [azurophil granule lumen]

GUSB [extracellular region]

GUSB [ficolin-1-rich granule lumen]

GUSB S52F [lysosomal lumen]

GUSB R356* [lysosomal lumen]

GUSB A354V [lysosomal lumen]

GUSB R216W [lysosomal lumen]

GUSB R611W [lysosomal lumen]

Inferred To

gusb [lysosomal lumen] (Xenopus tropicalis)

GUSB [lysosomal lumen] (Bos taurus)

GUSB [lysosomal lumen] (Caenorhabditis elegans)

GUSB [lysosomal lumen] (Canis familiaris)

GUSB [lysosomal lumen] (Gallus gallus)

GUSB [lysosomal lumen] (Sus scrofa)

Dmel\CG15117 [lysosomal lumen] (Drosophila melanogaster)

Gusb [lysosomal lumen] (Mus musculus)

Gusb [lysosomal lumen] (Rattus norvegicus)

Cross References

OpenTargets

ENSG00000169919

ENSEMBL

ENSP00000302728, ENST00000304895, ENST00000421103, ENSP00000391390

ZINC - Substances

BGLR_HUMAN

ZINC - Biogenic

BGLR_HUMAN

ZINC target

P08236

PRO

P08236

GlyGen

P08236

PDB

3HN3, 1BHG

IntEnz

3.2.1.31

HPA

ENSG00000169919-GUSB

Pharos - Targets

P08236

Orphanet

GUSB

ZINC - Predictions - Purchasable

BGLR_HUMAN

HMDB Protein

HMDBP00839

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P0DTC5 M	10	M [plasma membrane] (R-COV-9755780) N-glycan M [virion membrane] (R-COV-9694385) M [virion membrane] (R-COV-9694320) M [endocytic vesicle membrane] (R-COV-9694563) N-glycan M [endocytic vesicle membrane] (R-COV-9694738) M [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9694439) N-glycan M [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9694446) M [endoplasmic reticulum membrane] (R-COV-9767620) nascent M [endoplasmic reticulum lumen] (R-COV-9694279) N-glycan M [endoplasmic reticulum membrane] (R-COV-9694684)	0.547	2
UniProt:P11802 CDK4	3	p-T172-CDK4 [nucleoplasm] (R-HSA-113830) CDK4 [nucleoplasm] (R-HSA-113843) CDK4 [cytosol] (R-HSA-68330)	0.527	3

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