Reactome | UNC93B1 [endoplasmic reticulum membrane]

UNC93B1 [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-1678930

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

Unc93 homolog B1

Icon

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q9H1C4 UNC93B1

Gene Names

UNC93B1, UNC93, UNC93B

Chain

chain:1-597

Reference Genes

BioGPS Gene:81622 UNC93B1

COSMIC (genes):UNC93B1 UNC93B1

CTD Gene:81622 UNC93B1

dbSNP Gene:81622 UNC93B1

ENSEMBL:ENSG00000110057 UNC93B1

HGNC:13481 UNC93B1

KEGG:hsa:81622 UNC93B1

Monarch:81622 UNC93B1

NCBI Gene:81622 UNC93B1

OMIM:608204 UNC93B1

UCSC:Q9H1C4 UNC93B1

Reference Transcript

RefSeq:NM_030930.3 UNC93B1

Other Identifiers

11721322_at

16741173

17100833

220998_PM_s_at

220998_s_at

225869_PM_s_at

225869_s_at

2683250

2683252

2718105

2718108

2718113

2758606

2758607

2758608

2758633

2758635

2758636

3037672

3037673

3037674

3037675

3037678

3037682

3339081

3339082

3339084

3379132

3379270

3379271

3379272

3379273

3379276

3379277

3379278

3379279

3379280

3379281

3379282

3379283

3379284

3379285

3379286

3379287

3379288

3379289

3379290

3379291

3379292

3379293

3379294

3379295

3379296

3379297

3379298

3379299

49533_at

78054_at

7949904

8094144

8138147

81622

A_23_P98167

A_33_P3262758

GE61081

GO:0000139

GO:0000902

GO:0002224

GO:0002250

GO:0002376

GO:0002457

GO:0005515

GO:0005764

GO:0005768

GO:0005773

GO:0005783

GO:0005789

GO:0006886

GO:0016020

GO:0019882

GO:0019886

GO:0031410

GO:0032009

GO:0032735

GO:0032755

GO:0034138

GO:0034154

GO:0034162

GO:0035325

GO:0043226

GO:0045087

GO:0045335

GO:0051607

GO:0098542

HMNXSV003014560

Hs.135187.1.A1_3p_s_at

ILMN_1654812

ILMN_2193591

PH_hs_0027846

TC11001999.hg

g13569892_3p_s_at

Participates

as an input of

Full-length TLR3/7/8/9 binds to UNC93B1 (Homo sapiens)

as a component of

intracellular TLR:UNC93B1 [endoplasmic reticulum membrane] (Homo sapiens)

Other forms of this molecule

UNC93B1 [Golgi membrane]

UNC93B1 P345Pfs*103 [endoplasmic reticulum membrane]

UNC93B1 L230Afs*188 [endoplasmic reticulum membrane]

Inferred To

Unc93b1 [endoplasmic reticulum membrane] (Mus musculus)

Unc93b1 [endoplasmic reticulum membrane] (Rattus norvegicus)

UNC93B1 [endoplasmic reticulum membrane] (Bos taurus)

UNC93B1 [endoplasmic reticulum membrane] (Canis familiaris)

UNC93B1 [endoplasmic reticulum membrane] (Gallus gallus)

UNC93B1 [endoplasmic reticulum membrane] (Sus scrofa)

unc93b1 [endoplasmic reticulum membrane] (Danio rerio)

unc93b1 [endoplasmic reticulum membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_112192.2

OpenTargets

ENSG00000110057

ENSEMBL

ENSP00000227471, ENSG00000110057, ENST00000227471

GeneCards

UNC93B1

HPA

ENSG00000110057-UNC93B1

PRO

Q9H1C4

Pharos - Targets

Q9H1C4

GlyGen

Q9H1C4

Orphanet

UNC93B1

PDB

7CYN, 7C76

Interactors (72)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P37268 FDFT1	1	FDFT1 [endoplasmic reticulum membrane] (R-HSA-191369)	0.725	4
UniProt:Q96ER3 SAAL1			0.725	4
UniProt:Q96AQ6 PBIP1			0.643	3
UniProt:P24539 ATP5PB	1	ATP5PB [mitochondrial inner membrane] (R-HSA-164537)	0.643	3
UniProt:P18859 ATP5PF	1	ATP5PF [mitochondrial inner membrane] (R-HSA-164532)	0.643	3
UniProt:Q9GZM5 YIPF3			0.643	3
UniProt:Q9NR97 TLR8	4	TLR8 [endosome membrane] (R-HSA-1679577) TLR8 [Golgi membrane] (R-HSA-1678918) TLR8 [endolysosome membrane] (R-HSA-167927) TLR8 [endoplasmic reticulum membrane] (R-HSA-1678947)	0.602	4
UniProt:O60883 GPR37L1	1	GPR37L1 [plasma membrane] (R-HSA-5336178)	0.556	3
UniProt:Q96BA8 CREB3L1	7	CREB3L1 [Golgi membrane] (R-HSA-8874155) CREB3L1(427-519) [Golgi membrane] (R-HSA-8874139) CREB3L1(1-426) [Golgi membrane] (R-HSA-8874153) CREB3L1 [endoplasmic reticulum membrane] (R-HSA-8874157) CREB3L1(1-375) [cytosol] (R-HSA-8874215) CREB3L1(376-426) [Golgi membrane] (R-HSA-8874213) CREB3L1(1-375) [nucleoplasm] (R-HSA-8874222)	0.556	3
UniProt:A8MZ59 LEUTX	1	LEUTX [nucleoplasm] (R-HSA-9817277)	0.556	3
UniProt:O14843 FFAR3	1	FFAR3 [plasma membrane] (R-HSA-443951)	0.556	3
UniProt:P26715 KLRC1	1	KLRC1 [plasma membrane] (R-HSA-3006545)	0.556	3
UniProt:Q15125 EBP	1	EBP [endoplasmic reticulum membrane] (R-HSA-195697)	0.556	3
UniProt:Q9H902 REEP1	1	REEP1 [endoplasmic reticulum membrane] (R-HSA-8939766)	0.556	3
UniProt:Q9UM44 HHLA2			0.556	3
UniProt:Q8NFU1 BEST2	1	BEST2 [plasma membrane] (R-HSA-2744359)	0.556	3
UniProt:Q969F0 FATE1			0.556	3
UniProt:Q96Q45-2 TMEM237			0.556	3
UniProt:Q96P66 GP101			0.556	3
UniProt:Q96CE8 T4S18			0.556	3
UniProt:O95471 CLDN7	2	CLDN7 [cell junction] (R-HSA-421241) CLDN7 [plasma membrane] (R-HSA-420004)	0.556	3
UniProt:Q8WV48 CC107			0.556	3
UniProt:Q9Y282 ERGI3			0.556	3
UniProt:Q9NQQ7-3 Q9NQQ73			0.556	3
UniProt:Q8WWF3 SSMM1			0.556	3
UniProt:Q9GZY8-5 MFF			0.556	3
IntAct:EBI-23184686 CCSB ORF ID			0.556	3
UniProt:Q9H400 LIME1			0.556	3
UniProt:Q9NZD1 GPC5D			0.556	3
UniProt:P11912 CD79A	2	p-Y188,Y199-CD79A [plasma membrane] (R-HSA-983539) CD79A [plasma membrane] (R-HSA-197154)	0.556	3
UniProt:Q5T700 LRAD1			0.556	3
UniProt:Q9H7V2 SYNG1			0.556	3
UniProt:O15270 SPTLC2	1	PXLP-K379-SPTLC2 [endoplasmic reticulum membrane] (R-HSA-428146)	0.527	2
UniProt:B7ZAQ6 GPHRA			0.527	2
UniProt:O15269 SPTLC1	1	PXLP-K-SPTLC1 [endoplasmic reticulum membrane] (R-HSA-428155)	0.527	2
UniProt:Q9P035 HACD3	1	PTPLAD1 [endoplasmic reticulum membrane] (R-HSA-5676074)	0.527	2
UniProt:P36542 ATP5F1C	1	ATP5F1C [mitochondrial matrix] (R-HSA-164577)	0.527	2
UniProt:Q96R06 SPAG5			0.527	2
UniProt:Q6NUQ1 RINT1	1	RINT1 [cytosol] (R-HSA-6810991)	0.527	2
UniProt:Q9NTJ5 SACM1L	2	SACM1L [endoplasmic reticulum membrane] (R-HSA-1604637) SACM1L [Golgi membrane] (R-HSA-1806242)	0.527	2
UniProt:Q99442 SEC62			0.527	2
UniProt:P30049 ATP5F1D	1	ATP5F1D [mitochondrial matrix] (R-HSA-164574)	0.527	2
UniProt:P52429 DGKE	1	DGKE [plasma membrane] (R-HSA-426061)	0.527	2
UniProt:Q8WUY1 THEM6			0.527	2
UniProt:Q9UBV2 SEL1L	1	SEL1L [endoplasmic reticulum membrane] (R-HSA-1911545)	0.527	2
UniProt:Q9H7F0 AT133			0.527	2
UniProt:O75947 ATP5PD	1	ATP5PD [mitochondrial inner membrane] (R-HSA-50522)	0.527	2
UniProt:Q96KC8 DNJC1			0.527	2
UniProt:Q9NXE4 SMPD4	1	SMPD4 [endoplasmic reticulum membrane] (R-HSA-1606278)	0.527	2
UniProt:P56385 ATP5ME	1	ATP5ME [mitochondrial inner membrane] (R-HSA-50514)	0.527	2
UniProt:Q96DZ1 ERLEC1	1	ERLEC1 [endoplasmic reticulum quality control compartment] (R-HSA-5362354)	0.527	2
UniProt:P40855 PEX19	1	PEX19 [cytosol] (R-HSA-3009036)	0.527	2
UniProt:O95202 LETM1	2	LETM1 [endoplasmic reticulum membrane] (R-HSA-9714759) LETM1 [mitochondrial inner membrane] (R-HSA-8949702)	0.527	2
UniProt:Q13438 OS9	1	OS9 [endoplasmic reticulum membrane] (R-HSA-1022132)	0.527	2
UniProt:P04035 HMGCR	1	HMGCR [endoplasmic reticulum membrane] (R-HSA-9621345)	0.527	2
UniProt:Q6P4Q7 CNNM4			0.527	2
UniProt:Q5VV42 CDKAL1	1	CDKAL1 [endoplasmic reticulum membrane] (R-HSA-6786612)	0.527	2
UniProt:O75964 ATP5MG	1	ATP5MG [mitochondrial inner membrane] (R-HSA-50518)	0.527	2
UniProt:O95831 AIFM1			0.527	2
UniProt:Q15629 TRAM1	1	TRAM1 [endoplasmic reticulum membrane] (R-HSA-265084)	0.527	2
UniProt:Q9GZP9 DERL2	1	DERL2 [endoplasmic reticulum membrane] (R-HSA-5362350)	0.527	2
UniProt:Q8TEM1 NUP210	1	NUP210 [nuclear envelope] (R-HSA-157722)	0.527	2
UniProt:Q8N5G2 MACO1	1	MACO1 [endoplasmic reticulum membrane] (R-HSA-9714351)	0.527	2
UniProt:P06576 ATP5F1B	6	ATP5F1B [mitochondrial matrix] (R-HSA-164576) ATP5B(1-529) [cytosol] (R-HSA-1267973) ATP5B(1-529) [mitochondrial intermembrane space] (R-HSA-1267985) ATP5B(1-529) [mitochondrial inner membrane] (R-HSA-1299440) ATP5B(1-47) [mitochondrial matrix] (R-HSA-8986172) ATP5B [mitochondrial inner membrane] (R-HSA-1299441)	0.527	2
UniProt:Q8TC07 TBC1D15	1	TBC1D15 [cytosol] (R-HSA-8854150)	0.527	2
UniProt:Q15392 DHCR24	1	DHCR24 [endoplasmic reticulum membrane] (R-HSA-196414)	0.527	2
UniProt:P04843 RPN1	1	RPN1 [endoplasmic reticulum membrane] (R-HSA-264994)	0.527	2
UniProt:Q96KA5 CLP1L			0.527	2
UniProt:Q9C0E2 XPO4			0.527	2
UniProt:P55060 XPO2			0.499	2
UniProt:P0DTD8 NS7B			0.499	2
UniProt:Q14974 KPNB1	5	KPNB1 [cytosol] (R-HSA-180733) KPNB1 [nucleoplasm] (R-HSA-180714) KPNB1 [ficolin-1-rich granule lumen] (R-HSA-6800978) KPNB1 [extracellular region] (R-HSA-6806306) KPNB1 [specific granule lumen] (R-HSA-6799646)	0.499	2

Cite Us!