Endosomal TLRs pass through the Golgi

Stable Identifier
R-HSA-1678998
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
endoplasmic reticulum lumen, Golgi membrane
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Endosomal TLRs pass through the Golgi
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TLRs traffic through the Golgi complex by the conventional secretory pathway and are routed to endolysosomes where they bind their ligands (Chockalingam A et al 2008, Ewald SE et al 2011). .

Literature References
PubMed ID Title Journal Year
21402738 Nucleic acid recognition by Toll-like receptors is coupled to stepwise processing by cathepsins and asparagine endopeptidase

Ewald, SE, Engel, A, Lee, J, Wang, M, Bogyo, M, Barton, GM

J Exp Med 2011
19079358 TLR9 traffics through the Golgi complex to localize to endolysosomes and respond to CpG DNA

Chockalingam, A, Brooks, JC, Cameron, JL, Blum, LK, Leifer, CA

Immunol Cell Biol 2009
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Authored
Shamovsky, V  (2011-10-19)
Reviewed
Gillespie, ME  (2012-02-09)
Leifer, CA  (2012-02-28)
Rose II, WA  (2012-02-28)
Created
Shamovsky, V  (2011-10-19)
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