Reactome | TLR10 [plasma membrane]

TLR10 [plasma membrane]

Stable Identifier

R-HSA-167926

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Toll Like Receptor 10

Locations in the PathwayBrowser for interactor UniProt:O76024

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External Reference Information

External Reference

UniProt:Q9BXR5 TLR10

Gene Names

TLR10, UNQ315/PRO358

Chain

signal peptide:1-19, chain:20-811

Reference Genes

BioGPS Gene:81793 TLR10

COSMIC (genes):TLR10 TLR10

CTD Gene:81793 TLR10

dbSNP Gene:81793 TLR10

ENSEMBL:ENSG00000174123 TLR10

ENSEMBL_homo_sapiens_GENE:ENSG00000174123.11 TLR10

HGNC:15634 TLR10

KEGG Gene (Homo sapiens):81793 TLR10

Monarch:81793 TLR10

NCBI Gene:81793 TLR10

OMIM:606270 TLR10

UCSC:Q9BXR5 TLR10

Reference Transcript

Other Identifiers

11746406_a_at

11746407_x_at

11746534_a_at

16975203

223750_PM_s_at

223750_s_at

223751_PM_x_at

223751_x_at

2766193

2766194

2766195

2766196

2766197

2766198

2766199

2766200

2766201

2766202

2766203

2766204

2766207

42617_r_at

42618_at

48329_at

8099826

81793

A_33_P3383970

GE83204

GO:0002224

GO:0002376

GO:0003824

GO:0004888

GO:0005515

GO:0005886

GO:0006954

GO:0006955

GO:0007165

GO:0008289

GO:0016020

GO:0016787

GO:0023052

GO:0035663

GO:0038023

GO:0042802

GO:0043235

GO:0045087

GO:0050135

GO:0060089

GO:0061809

GO:0071221

GO:0071723

GO:0098542

HMNXSV003040472

Hs.120551.0.S1_3p_s_at

ILMN_1719905

ILMN_2298366

ILMN_2414762

PH_hs_0006666

TC04001123.hg

g13447752_3p_s_at

Participates

as an input of

Ligand binds to TLR10 (Homo sapiens)

as a component of

TLR10 homodimer [plasma membrane] (Homo sapiens)

Inferred To

Tehao [plasma membrane] (Drosophila melanogaster)

tlr6 [plasma membrane] (Xenopus tropicalis)

TLR10 [plasma membrane] (Bos taurus)

TLR10 [plasma membrane] (Danio rerio)

TLR10 [plasma membrane] (Gallus gallus)

TLR10 [plasma membrane] (Sus scrofa)

chTLR1-type2 [plasma membrane] (Gallus gallus)

Homologues of TLR10 [plasma membrane] (Drosophila melanogaster)

Homologues of TLR10 [plasma membrane] (Gallus gallus)

Homologues of TLR10 [plasma membrane] (Xenopus tropicalis)

MstProx [plasma membrane] (Drosophila melanogaster)

Tl [plasma membrane] (Drosophila melanogaster)

Toll-9 [plasma membrane] (Drosophila melanogaster)

Tlr10 [plasma membrane] (Rattus norvegicus)

XB5889249 [plasma membrane] (Xenopus tropicalis)

Toll-4 [plasma membrane] (Drosophila melanogaster)

Cross References

RefSeq

NP_001182037.1, NP_112218.2, NP_001182036.1, XP_011512064.1, NP_001017388.1, XP_011512063.1, NP_001182035.1

Guide to Pharmacology - Targets

1760

OpenTargets

ENSG00000174123

HPA

ENSG00000174123-TLR10

GeneCards

Q9BXR5

Ensembl

ENSP00000308925, ENSP00000354459, ENST00000622002, ENST00000506111, ENST00000508334, ENSP00000478985, ENST00000361424, ENSG00000174123, ENSP00000478206, ENSP00000421483, ENST00000308973, ENST00000613579, ENSP00000424923

PRO

Q9BXR5

Pharos - Targets

Q9BXR5

PDB

2J67

HMDB Protein

HMDBP12383

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O60603 TLR2	3	TLR2 [plasma membrane] (R-HSA-9637646) TLR2 [secretory granule membrane] (R-HSA-6804777) TLR2 [plasma membrane] (R-HSA-167992)	0.573	3
UniProt:Q9BXR5 TLR10	1	TLR10 [plasma membrane] (R-HSA-167926)	0.573	3
UniProt:Q15399 TLR1	1	TLR1 [plasma membrane] (R-HSA-6787702)	0.573	3
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:P54252 ATXN3	2	ATXN3 [nucleoplasm] (R-HSA-6783285) ATXN3 [cytosol] (R-HSA-5625607)	0.556	3

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