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TLR3 [endolysosome membrane]
Stable Identifier
R-HSA-167941
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endolysosome membrane
Synonyms
Toll-like Receptor 3
Icon
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Trafficking and processing of endosomal TLR (Homo sapiens)
UNC93B1 delivers endosomal full-length TLRs to endolysosome (Homo sapiens)
TLR3 [endolysosome membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:O15455 TLR3
Gene Names
TLR3
Chain
signal peptide:1-23, chain:24-904
Reference Genes
BioGPS Gene:7098 TLR3
COSMIC (genes):TLR3 TLR3
CTD Gene:7098 TLR3
dbSNP Gene:7098 TLR3
ENSEMBL:ENSG00000164342 TLR3
ENSEMBL_homo_sapiens_GENE:ENSG00000164342.14 TLR3
HGNC:11849 TLR3
KEGG Gene (Homo sapiens):7098 TLR3
Monarch:7098 TLR3
NCBI Gene:7098 TLR3
OMIM:603029 TLR3
UCSC:O15455 TLR3
Reference Transcript
RefSeq:XM_017008577.1 TLR3
RefSeq:NM_003265.2 TLR3
Other Identifiers
11730296_a_at
16972993
206271_PM_at
206271_at
239587_PM_at
239587_at
242667_PM_at
242667_at
2754939
2754943
2754944
2754945
2754946
2754947
2754948
2754949
2754950
2754951
2754952
2754953
2754954
2754955
2754956
2754957
2754958
2754959
2754960
2754961
2754962
2754963
2754964
2754972
33488_at
7098
79848_at
80052_i_at
80054_r_at
8098611
A_23_P29922
A_32_P171793
A_32_P49054
GE476559
GE59525
GO:0000139
GO:0000165
GO:0001774
GO:0002224
GO:0002376
GO:0002730
GO:0003723
GO:0003725
GO:0004888
GO:0005515
GO:0005576
GO:0005615
GO:0005737
GO:0005764
GO:0005765
GO:0005768
GO:0005769
GO:0005773
GO:0005783
GO:0005789
GO:0005794
GO:0005886
GO:0006351
GO:0006355
GO:0006952
GO:0006954
GO:0006955
GO:0006972
GO:0007165
GO:0007250
GO:0007252
GO:0007254
GO:0008584
GO:0009597
GO:0009615
GO:0010008
GO:0010628
GO:0012501
GO:0016020
GO:0022414
GO:0023052
GO:0030154
GO:0030312
GO:0031012
GO:0031410
GO:0032481
GO:0032722
GO:0032727
GO:0032728
GO:0032729
GO:0032735
GO:0032755
GO:0032757
GO:0032760
GO:0034138
GO:0034343
GO:0034346
GO:0035458
GO:0036020
GO:0036211
GO:0038023
GO:0038187
GO:0042742
GO:0042802
GO:0043065
GO:0043123
GO:0043226
GO:0043330
GO:0043331
GO:0045087
GO:0045671
GO:0045766
GO:0045944
GO:0046330
GO:0048856
GO:0050729
GO:0051607
GO:0060089
GO:0060907
GO:0071260
GO:0071346
GO:0071360
GO:0071466
GO:0090594
GO:0097191
GO:0097527
GO:0098542
GO:0098586
GO:1900017
GO:1901224
HMNXSV003003562
Hs.145926.0.A1_3p_at
Hs.201600.0.A1_3p_at
ILMN_1689578
ILMN_2155708
PH_hs_0002558
TC04000912.hg
TC04002368.hg
g4507530_3p_at
Participates
as an output of
UNC93B1 delivers endosomal full-length TLRs to endolysosome (Homo sapiens)
Other forms of this molecule
TLR3 E746* [endosome membrane]
TLR3 P554S [endosome membrane]
TLR3 [endoplasmic reticulum membrane]
TLR3 [Golgi membrane]
TLR3 [endosome membrane]
Inferred To
TLR3 [endolysosome membrane]
(Bos taurus)
TLR3 [endolysosome membrane]
(Canis familiaris)
Cross References
RefSeq
XP_016864066.1
,
NP_003256.1
Guide to Pharmacology - Targets
1753
OpenTargets
ENSG00000164342
HPA
ENSG00000164342-TLR3
GeneCards
O15455
Ensembl
ENST00000296795
,
ENSP00000513668
,
ENSP00000296795
,
ENSP00000513677
,
ENST00000504367
,
ENST00000508051
,
ENST00000512264
,
ENST00000698354
,
ENSG00000164342
,
ENSP00000513676
,
ENSP00000423684
PRO
O15455
Pharos - Targets
O15455
Orphanet
17715
PDB
3ULV
,
7WV4
,
7WVF
,
7C76
,
8AR1
,
7WV5
,
7WV3
,
5GS0
,
7WVE
,
1ZIW
,
2MK9
,
2A0Z
,
2MKA
,
3ULU
,
7WVJ
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O15455 TLR3
6
TLR3 E746* [endosome membrane]
(R-HSA-5602730)
TLR3 P554S [endosome membrane]
(R-HSA-5602428)
TLR3 [endoplasmic reticulum membrane]
(R-HSA-1679057)
TLR3 [endolysosome membrane]
(R-HSA-167941)
TLR3 [Golgi membrane]
(R-HSA-1678955)
TLR3 [endosome membrane]
(R-HSA-2000341)
0.744
5
UniProt:P27986 PIK3R1
16
p-Y-PIK3R1 [cytosol]
(R-HSA-9680647)
PIK3R1 G376R [plasma membrane]
(R-HSA-2399717)
PIK3R1 K379E [plasma membrane]
(R-HSA-8944148)
PIK3R1 Y463_L466del [plasma membrane]
(R-HSA-2399546)
PIK3R1 H450_E451del [plasma membrane]
(R-HSA-2399545)
PIK3R1 R574_T576del [plasma membrane]
(R-HSA-2399544)
PIK3R1 D560Y [plasma membrane]
(R-HSA-2399421)
PIK3R1 N564D [plasma membrane]
(R-HSA-2399427)
PIK3R1 K459del [plasma membrane]
(R-HSA-2399554)
PIK3R1 N564K [plasma membrane]
(R-HSA-2399431)
PIK3R1 D560H [plasma membrane]
(R-HSA-2399432)
PIK3R1 R574I [plasma membrane]
(R-HSA-2399536)
PIK3R1 R574T [plasma membrane]
(R-HSA-2399540)
K63polyUb-PIK3R1 [cytosol]
(R-HSA-3080572)
PIK3R1 [cytosol]
(R-HSA-74789)
PIK3R1 [plasma membrane]
(R-HSA-198365)
0.524
2
UniProt:P11226 MBL2
1
MBL2 [extracellular region]
(R-HSA-166674)
0.463
2
UniProt:Q7L0X0 TRIL
0.463
2
UniProt:P12931 SRC
6
p-Y419-SRC [nucleoplasm]
(R-HSA-8937690)
SRC [cytosol]
(R-HSA-9628701)
p-Y419-SRC [cytosol]
(R-HSA-8964276)
MyrG-SRC [plasma membrane]
(R-HSA-8876922)
MyrG,p-Y530-SRC [plasma membrane]
(R-HSA-377598)
MyrG-p-Y419-SRC [plasma membrane]
(R-HSA-1810408)
0.463
2
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