Reactome | Ligand binds to TLR7 or TLR8

Ligand binds to TLR7 or TLR8

Stable Identifier

R-HSA-167983

Type

Reaction [binding]

Species

Homo sapiens

Compartment

endosome membrane, cytosol

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Endosomal recognition of influenza genomic RNA and imidazoquinoline compounds occurs by means of TLR7 and TLR8.

Literature References

PubMed ID	Title	Journal	Year
14976261	Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA Diebold, SS, Kaisho, T, Hemmi, H, Akira, S, Reis e Sousa, C	Science	2004
12032557	Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848 Jurk, M, Heil, F, Vollmer, J, Schetter, C, Krieg, AM, Wagner, H, Lipford, G, Bauer, S	Nat Immunol	2002
11812998	Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway Hemmi, H, Kaisho, T, Takeuchi, O, Sato, S, Sanjo, H, Hoshino, K, Horiuchi, T, Tomizawa, H, Takeda, K, Akira, S	Nat Immunol	2002
14976262	Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8 Heil, F, Hemmi, H, Hochrein, H, Ampenberger, F, Kirschning, C, Akira, S, Lipford, G, Wagner, H, Bauer, S	Science	2004