Ligand binds to TLR7 or TLR8

Stable Identifier
R-HSA-167983
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Endosomal recognition of influenza genomic RNA and imidazoquinoline compounds occurs by means of TLR7 and TLR8.

Literature References
PubMed ID Title Journal Year
14976261 Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA

Diebold, SS, Kaisho, T, Hemmi, H, Akira, S, Reis e Sousa, C

Science 2004
12032557 Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848

Jurk, M, Heil, F, Vollmer, J, Schetter, C, Krieg, AM, Wagner, H, Lipford, G, Bauer, S

Nat Immunol 2002
11812998 Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway

Hemmi, H, Kaisho, T, Takeuchi, O, Sato, S, Sanjo, H, Hoshino, K, Horiuchi, T, Tomizawa, H, Takeda, K, Akira, S

Nat Immunol 2002
14976262 Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8

Heil, F, Hemmi, H, Hochrein, H, Ampenberger, F, Kirschning, C, Akira, S, Lipford, G, Wagner, H, Bauer, S

Science 2004
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created