Reactome | MAP2K6 [cytosol]

MAP2K6 [cytosol]

Stable Identifier

R-HSA-167998

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

MKK6, mitogen-activated protein kinase kinase 6

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External Reference Information

External Reference

UniProt:P52564 MAP2K6

Gene Names

MAP2K6, MEK6, MKK6, PRKMK6, SKK3

Chain

chain:1-334

Reference Genes

COSMIC (genes):MAP2K6 MAP2K6

dbSNP Gene:5608 MAP2K6

ENSEMBL:ENSG00000108984 MAP2K6

Participates

as an input of

as a member of

MAP2K3,MAP2K6 [cytosol] (Homo sapiens)

Other forms of this molecule

p-S207,T211-MAP2K6 [cytosol]

p-S207,T211-MAP2K6 [nucleoplasm]

Inferred To

Homologues of MAP2K6 [cytosol] (Caenorhabditis elegans)

sek-4 [cytosol] (Caenorhabditis elegans)

MAP2K6 [cytosol] (Bos taurus)

MAP2K6 [cytosol] (Caenorhabditis elegans)

MAP2K6 [cytosol] (Canis familiaris)

MAP2K6 [cytosol] (Danio rerio)

MAP2K6 [cytosol] (Dictyostelium discoideum)

MAP2K6 [cytosol] (Gallus gallus)

MAP2K6 [cytosol] (Mus musculus)

MAP2K6 [cytosol] (Rattus norvegicus)

MAP2K6 [cytosol] (Sus scrofa)

MAP2K6 [cytosol] (Xenopus tropicalis)

sek-5 [cytosol] (Caenorhabditis elegans)

lic [cytosol] (Drosophila melanogaster)

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q16236 NFE2L2	13	p-S40-NFE2L2 [nucleoplasm] (R-HSA-9715109) p-S,T-NFE2L2 [nucleoplasm] (R-HSA-9715110) p-S40-NFE2L2 [cytosol] (R-HSA-8932290) p-S,T-NFE2L2 [cytosol] (R-HSA-8932311) NFE2L2 [cytosol] (R-HSA-201566) p-S,T-18 AcK-NFE2L2 [nucleoplasm] (R-HSA-9760033) p-S40-18 AcK-NFE2L2 [nucleoplasm] (R-HSA-9760018) ub-NFE2L2 [cytosol] (R-HSA-9758077) ub-p-S335, S338,T-NFE2L2 [nucleoplasm] (R-HSA-9762055) ub-p-S40, S335, S338- NFE2L2 [nucleoplasm] (R-HSA-9762058) p-S344, S347,T-NFE2L2 [nucleoplasm] (R-HSA-9762048) p-S40, S344, S347- NFE2L2 [nucleoplasm] (R-HSA-9762050) p-S,T,S558-NFE2L2 [nucleoplasm] (R-HSA-9795736)	0.625	5
UniProt:P46734 MAP2K3	3	MAP2K3 [cytosol] (R-HSA-168051) p-S218,T222-MAP2K3 [cytosol] (R-HSA-167955) p-S218,T222-MAP2K3 [nucleoplasm] (R-HSA-450229)	0.615	3
UniProt:Q16539 MAPK14	7	MAPK14 [ficolin-1-rich granule lumen] (R-HSA-6803280) MAPK14 [extracellular region] (R-HSA-6806453) MAPK14 [secretory granule lumen] (R-HSA-6803300) MAPK14 [nucleoplasm] (R-HSA-446223) MAPK14 [cytosol] (R-HSA-428933) p-T180,Y182-MAPK14 [cytosol] (R-HSA-428935) p-T180,Y182-MAPK14 [nucleoplasm] (R-HSA-446227)	0.564	3
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:Q9NRD5 PICK1	2	PICK1 [plasma membrane] (R-HSA-416989) PICK1 [endocytic vesicle membrane] (R-HSA-417017)	0.556	3
UniProt:P24522 GADD45A	1	GADD45A [nucleoplasm] (R-HSA-3215139)	0.519	2
UniProt:Q9Y6R4 M3K4			0.519	2
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.463	4

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