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MAP2K6 [cytosol]
Stable Identifier
R-HSA-167998
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
MKK6, mitogen-activated protein kinase kinase 6
Icon
Locations in the PathwayBrowser for interactor UniProt:Q9NRD5%20PICK1
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Interferon Signaling (Homo sapiens)
Antiviral mechanism by IFN-stimulated genes (Homo sapiens)
PKR-mediated signaling (Homo sapiens)
p-PKR dimer phosphorylates MKK6 (Homo sapiens)
MAP2K6 [cytosol] (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-1 family signaling (Homo sapiens)
Interleukin-1 signaling (Homo sapiens)
TAK1 phosphorylates MKK6 (Homo sapiens)
MAP2K6 [cytosol] (Homo sapiens)
Innate Immune System (Homo sapiens)
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways (Homo sapiens)
NOD1/2 Signaling Pathway (Homo sapiens)
TAK1 phosphorylates MKK6 (Homo sapiens)
MAP2K6 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P52564 MAP2K6
Gene Names
MAP2K6, MEK6, MKK6, PRKMK6, SKK3
Chain
chain:1-334
Reference Genes
BioGPS Gene:5608 MAP2K6
COSMIC (genes):MAP2K6 MAP2K6
CTD Gene:5608 MAP2K6
dbSNP Gene:5608 MAP2K6
ENSEMBL:ENSG00000108984 MAP2K6
ENSEMBL_homo_sapiens_GENE:ENSG00000108984.16 MAP2K6
HGNC:6846 MAP2K6
KEGG Gene (Homo sapiens):5608 MAP2K6
Monarch:5608 MAP2K6
NCBI Gene:5608 MAP2K6
OMIM:601254 MAP2K6
UCSC:P52564 MAP2K6
Reference Transcript
RefSeq:NM_001330450.1 MAP2K6
RefSeq:NM_002758.3 MAP2K6
RefSeq:XM_005257516.2 MAP2K6
RefSeq:XM_006721975.3 MAP2K6
RefSeq:XM_011525027.2 MAP2K6
Other Identifiers
11724606_a_at
11758909_at
1543_at
16837348
2014_s_at
205698_PM_s_at
205698_s_at
205699_PM_at
205699_at
229569_PM_at
229569_at
3725938
3733071
3733072
3733073
3733082
3733083
3733084
3733089
3733091
3733092
3733093
3733095
3733097
3733099
3733101
3733104
3733107
3733113
3733118
3733119
3733120
3733121
3733122
3733123
3733124
3733125
3733126
3733127
43958_at
5608
76095_at
7896639
8009476
83039_at
A_14_P106339
A_14_P130621
A_14_P201634
A_19_P00316010
A_19_P00812873
A_23_P207445
A_24_P416489
A_32_P44210
GE59129
GE608685
GE613227
GO:0000165
GO:0000166
GO:0001649
GO:0001934
GO:0002376
GO:0002931
GO:0003012
GO:0003013
GO:0003824
GO:0004672
GO:0004674
GO:0004708
GO:0004713
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005856
GO:0006468
GO:0006915
GO:0007165
GO:0009410
GO:0012501
GO:0016301
GO:0016310
GO:0016740
GO:0019901
GO:0022414
GO:0022602
GO:0023052
GO:0030154
GO:0031098
GO:0032308
GO:0036211
GO:0038066
GO:0042770
GO:0042802
GO:0043065
GO:0043226
GO:0043410
GO:0048856
GO:0051403
GO:0051726
GO:0051770
GO:0060048
GO:0060348
GO:0070423
GO:0072709
GO:0090398
GO:0098542
GO:0106310
GO:0120163
GO:0140096
GO:1901796
HMNXSV003039586
Hs.26017.0.A1_3p_at
ILMN_1660964
ILMN_1697729
PH_hs_0023282
TC17000807.hg
U39657_at
g10835026_3p_a_at
g1203817_3p_at
p7482
Participates
as an input of
p-PKR dimer phosphorylates MKK6 (Homo sapiens)
TAK1 phosphorylates MKK6 (Homo sapiens)
as a member of
MAP2K3,MAP2K6 [cytosol] (Homo sapiens)
Other forms of this molecule
p-S207,T211-MAP2K6 [cytosol]
p-S207,T211-MAP2K6 [nucleoplasm]
Inferred To
Homologues of MAP2K6 [cytosol]
(Caenorhabditis elegans)
sek-4 [cytosol]
(Caenorhabditis elegans)
MAP2K6 [cytosol]
(Bos taurus)
MAP2K6 [cytosol]
(Caenorhabditis elegans)
MAP2K6 [cytosol]
(Canis familiaris)
MAP2K6 [cytosol]
(Danio rerio)
MAP2K6 [cytosol]
(Dictyostelium discoideum)
MAP2K6 [cytosol]
(Gallus gallus)
MAP2K6 [cytosol]
(Mus musculus)
MAP2K6 [cytosol]
(Rattus norvegicus)
MAP2K6 [cytosol]
(Sus scrofa)
MAP2K6 [cytosol]
(Xenopus tropicalis)
sek-5 [cytosol]
(Caenorhabditis elegans)
lic [cytosol]
(Drosophila melanogaster)
Cross References
RefSeq
XP_005257573.1
,
NP_001317379.1
,
XP_006722038.1
,
NP_002749.2
,
XP_011523329.1
ZINC - World Drugs
MP2K6_HUMAN
Guide to Pharmacology - Targets
2067
OpenTargets
ENSG00000108984
ZINC - FDA approved
MP2K6_HUMAN
ZINC - Substances
MP2K6_HUMAN
ZINC - Biogenic
MP2K6_HUMAN
ZINC target
P52564
PRO
P52564
PDB
8P7J
,
8A8M
,
8PM3
,
2Y8O
,
3ENM
,
3FME
,
3VN9
,
5ETF
ZINC - Investigational
MP2K6_HUMAN
GeneCards
P52564
HPA
ENSG00000108984-MAP2K6
Ensembl
ENSG00000108984
,
ENST00000589647
,
ENSP00000468348
,
ENSP00000467213
,
ENST00000590474
Pharos - Targets
P52564
ZINC - Predictions - Purchasable
MP2K6_HUMAN
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q16236 NFE2L2
13
p-S,T,S558-NFE2L2 [nucleoplasm]
(R-HSA-9795736)
p-S40, S344, S347- NFE2L2 [nucleoplasm]
(R-HSA-9762050)
p-S344, S347,T-NFE2L2 [nucleoplasm]
(R-HSA-9762048)
ub-p-S40, S335, S338- NFE2L2 [nucleoplasm]
(R-HSA-9762058)
ub-p-S335, S338,T-NFE2L2 [nucleoplasm]
(R-HSA-9762055)
ub-NFE2L2 [cytosol]
(R-HSA-9758077)
p-S40-18 AcK-NFE2L2 [nucleoplasm]
(R-HSA-9760018)
p-S,T-18 AcK-NFE2L2 [nucleoplasm]
(R-HSA-9760033)
NFE2L2 [cytosol]
(R-HSA-201566)
p-S,T-NFE2L2 [cytosol]
(R-HSA-8932311)
p-S40-NFE2L2 [cytosol]
(R-HSA-8932290)
p-S,T-NFE2L2 [nucleoplasm]
(R-HSA-9715110)
p-S40-NFE2L2 [nucleoplasm]
(R-HSA-9715109)
0.625
5
UniProt:Q16539 MAPK14
7
MAPK14 [secretory granule lumen]
(R-HSA-6803300)
MAPK14 [extracellular region]
(R-HSA-6806453)
MAPK14 [ficolin-1-rich granule lumen]
(R-HSA-6803280)
MAPK14 [nucleoplasm]
(R-HSA-446223)
MAPK14 [cytosol]
(R-HSA-428933)
p-T180,Y182-MAPK14 [cytosol]
(R-HSA-428935)
p-T180,Y182-MAPK14 [nucleoplasm]
(R-HSA-446227)
0.564
3
UniProt:O76024 WFS1
3
WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956747)
p-WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956998)
WFS1 [endoplasmic reticulum membrane]
(R-HSA-535474)
0.556
3
UniProt:Q9NRD5 PICK1
2
PICK1 [plasma membrane]
(R-HSA-416989)
PICK1 [endocytic vesicle membrane]
(R-HSA-417017)
0.556
3
UniProt:P24522 GADD45A
1
GADD45A [nucleoplasm]
(R-HSA-3215139)
0.519
2
UniProt:Q9Y6R4 M3K4
0.519
2
UniProt:P46734 MAP2K3
3
MAP2K3 [cytosol]
(R-HSA-168051)
p-S218,T222-MAP2K3 [cytosol]
(R-HSA-167955)
p-S218,T222-MAP2K3 [nucleoplasm]
(R-HSA-450229)
0.483
2
UniProt:Q5S007 LRRK2
1
LRRK2 [cytosol]
(R-HSA-5661173)
0.463
4
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