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ECSIT [cytosol]
Stable Identifier
R-HSA-168064
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
evolutionarily conserved signaling intermediate in Toll pathway
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 10 (TLR10) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
TRAF6 binds MEKK1 (Homo sapiens)
ECSIT [cytosol] (Homo sapiens)
Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
TRAF6 binds MEKK1 (Homo sapiens)
ECSIT [cytosol] (Homo sapiens)
Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
TRAF6 binds MEKK1 (Homo sapiens)
ECSIT [cytosol] (Homo sapiens)
Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
TRAF6 binds MEKK1 (Homo sapiens)
ECSIT [cytosol] (Homo sapiens)
Toll Like Receptor 5 (TLR5) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
TRAF6 binds MEKK1 (Homo sapiens)
ECSIT [cytosol] (Homo sapiens)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
TRAF6 binds MEKK1 (Homo sapiens)
ECSIT [cytosol] (Homo sapiens)
Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
TRAF6 binds MEKK1 (Homo sapiens)
ECSIT [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9BQ95 ECSIT
Gene Names
ECSIT
Chain
transit peptide:1-48, chain:49-431
Reference Genes
BioGPS Gene:51295 ECSIT
COSMIC (genes):ECSIT ECSIT
CTD Gene:51295 ECSIT
dbSNP Gene:51295 ECSIT
ENSEMBL:ENSG00000130159 ECSIT
HGNC:29548 ECSIT
KEGG Gene (Homo sapiens):51295 ECSIT
Monarch:51295 ECSIT
NCBI Gene:51295 ECSIT
OMIM:608388 ECSIT
UCSC:Q9BQ95 ECSIT
Reference Transcript
RefSeq:NM_001142464.2 ECSIT
RefSeq:NM_001243204.1 ECSIT
RefSeq:NM_001142465.2 ECSIT
RefSeq:NM_016581.4 ECSIT
Other Identifiers
0002630605
11718417_a_at
16869006
218225_at
3851013
3851014
3851015
3851017
3851019
3851021
3851022
3851023
3851025
3851027
3851028
3851031
3851036
3851037
3851041
3851047
3851048
49013_at
51295
8034286
A_23_P119295
GE55010
GO:0002376
GO:0003674
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005743
GO:0005829
GO:0006950
GO:0007005
GO:0008150
GO:0022607
GO:0032981
GO:0043226
GO:0045087
GO:0051341
GO:0061635
GO:0065003
ILMN_1687769
ILMN_2233604
PH_hs_0001937
TC19002336.hg
TC19002679.hg
g7706114_3p_at
This entity regulates
Positively
TRAF6 binds MEKK1
Other forms of this molecule
ECSIT [mitochondrial inner membrane]
Inferred To
ECSIT [cytosol] (Bos taurus)
ECSIT [cytosol] (Canis familiaris)
ECSIT [cytosol] (Gallus gallus)
ECSIT [cytosol] (Sus scrofa)
ecsit [cytosol] (Danio rerio)
ecsit [cytosol] (Xenopus tropicalis)
Ecsit [cytosol] (Mus musculus)
Ecsit [cytosol] (Rattus norvegicus)
Cross References
RefSeq
NP_001230133.1
,
NP_057665.2
,
NP_001135936.1
,
NP_001135937.1
OpenTargets
ENSG00000130159
HPA
ENSG00000130159-ECSIT
GeneCards
Q9BQ95
Ensembl
ENSP00000412712
,
ENST00000591104
,
ENST00000252440
,
ENST00000417981
,
ENST00000270517
,
ENSP00000466559
,
ENSP00000270517
,
ENSP00000252440
,
ENSG00000130159
PRO
Q9BQ95
Orphanet
24498
HMDB Protein
HMDBP08887
Interactors (24)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9H845 ACAD9
1
ACAD9 [mitochondrial inner membrane]
(R-HSA-5689049)
0.643
4
UniProt:P49768 PSEN1
6
PSEN1(299-467) [azurophil granule membrane]
(R-HSA-6799234)
PSEN1(1-467) [plasma membrane]
(R-HSA-201606)
PSEN1(1-467) [azurophil granule membrane]
(R-HSA-6799235)
PSEN1(1-298) [azurophil granule membrane]
(R-HSA-6799209)
PSEN1(1-298) [plasma membrane]
(R-HSA-2534298)
PSEN1(299-467) [plasma membrane]
(R-HSA-2534245)
0.582
4
UniProt:P55040 GEM
0.556
3
UniProt:Q9NX04 CA109
0.556
3
UniProt:Q96PN8 TSSK3
0.556
3
UniProt:Q13064 MKRN3
0.556
3
UniProt:Q13515 BFSP2
0.556
3
UniProt:Q86UW9 DTX2
1
DTX2 [cytosol]
(R-HSA-1604436)
0.556
3
UniProt:Q9UBU9 NXF1
2
NXF1 [nucleoplasm]
(R-HSA-111690)
NXF1 [cytosol]
(R-HSA-156481)
0.556
3
UniProt:Q9UI47-2 CTNNA3
0.556
3
UniProt:A2RTX5 SYTC2
0.556
3
UniProt:O15479 MAGB2
0.556
3
UniProt:Q9P0J0 NDUFA13
1
NDUFA13 [mitochondrial inner membrane]
(R-HSA-59936)
0.527
2
UniProt:Q66LE6 PPP2R2D
1
PPP2R2D [nucleoplasm]
(R-HSA-2160962)
0.527
2
UniProt:P63151 PPP2R2A
2
PPP2R2A [nucleoplasm]
(R-HSA-1564978)
PPP2R2A [cytosol]
(R-HSA-377253)
0.527
2
UniProt:Q9BQP7 MGME1
0.527
2
UniProt:Q9Y285 FARSA
1
FARSA [cytosol]
(R-HSA-379667)
0.527
2
UniProt:P0DTD3 Y14
0.527
2
UniProt:Q9Y375 NDUFAF1
1
NDUFAF1 [mitochondrial inner membrane]
(R-HSA-5689050)
0.527
3
UniProt:Q9NPL8 TIMMDC1
1
TIMMDC1 [mitochondrial inner membrane]
(R-HSA-5689720)
0.527
3
UniProt:P03905 MT-ND4
1
MT-ND4 [mitochondrial inner membrane]
(R-HSA-60561)
0.527
2
UniProt:O75489 NDUFS3
1
NDUFS3 [mitochondrial matrix]
(R-HSA-163927)
0.527
2
UniProt:P49810 PSEN2
2
PSEN2(298-448) [plasma membrane]
(R-HSA-9013329)
PSEN2(1-297) [plasma membrane]
(R-HSA-201599)
0.524
4
UniProt:P02649 APOE
9
APOE [endosome lumen]
(R-HSA-174804)
APOE [endocytic vesicle lumen]
(R-HSA-3221641)
APOE [endosome membrane]
(R-HSA-174766)
APOE [clathrin-coated endocytic vesicle membrane]
(R-HSA-174651)
APOE [plasma membrane]
(R-HSA-174615)
APOE [early endosome]
(R-HSA-2429687)
p-APOE [endoplasmic reticulum lumen]
(R-HSA-8956980)
APOE [endoplasmic reticulum lumen]
(R-HSA-6784908)
APOE [extracellular region]
(R-HSA-174646)
0.524
4
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