Reactome | ECSIT [cytosol]

ECSIT [cytosol]

Stable Identifier

R-HSA-168064

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

evolutionarily conserved signaling intermediate in Toll pathway

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9BQ95 ECSIT

Gene Names

ECSIT

Chain

transit peptide:1-48, chain:49-431

Reference Genes

BioGPS Gene:51295 ECSIT

COSMIC (genes):ECSIT ECSIT

CTD Gene:51295 ECSIT

dbSNP Gene:51295 ECSIT

ENSEMBL:ENSG00000130159 ECSIT

HGNC:29548 ECSIT

KEGG Gene (Homo sapiens):51295 ECSIT

Monarch:51295 ECSIT

NCBI Gene:51295 ECSIT

OMIM:608388 ECSIT

UCSC:Q9BQ95 ECSIT

Reference Transcript

Other Identifiers

0002630605

11718417_a_at

16869006

218225_at

3851013

3851014

3851015

3851017

3851019

3851021

3851022

3851023

3851025

3851027

3851028

3851031

3851036

3851037

3851041

3851047

3851048

49013_at

51295

8034286

A_23_P119295

GE55010

GO:0002376

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0005743

GO:0005829

GO:0006950

GO:0007005

GO:0008150

GO:0022607

GO:0032981

GO:0043226

GO:0045087

GO:0051341

GO:0061635

GO:0065003

ILMN_1687769

ILMN_2233604

PH_hs_0001937

TC19002336.hg

TC19002679.hg

g7706114_3p_at

This entity regulates

Positively

TRAF6 binds MEKK1

Other forms of this molecule

ECSIT [mitochondrial inner membrane]

Inferred To

ECSIT [cytosol] (Bos taurus)

ECSIT [cytosol] (Canis familiaris)

ECSIT [cytosol] (Gallus gallus)

ECSIT [cytosol] (Sus scrofa)

ecsit [cytosol] (Danio rerio)

ecsit [cytosol] (Xenopus tropicalis)

Ecsit [cytosol] (Mus musculus)

Ecsit [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_001135937.1, NP_057665.2, NP_001135936.1, NP_001230133.1

OpenTargets

ENSG00000130159

HPA

ENSG00000130159-ECSIT

GeneCards

Q9BQ95

Ensembl

ENSG00000130159, ENSP00000252440, ENST00000591104, ENST00000417981, ENST00000270517, ENSP00000466559, ENSP00000270517, ENSP00000412712, ENST00000252440

PRO

Q9BQ95

Orphanet

24498

HMDB Protein

HMDBP08887

Interactors (23)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9H845 ACAD9	1	ACAD9 [mitochondrial inner membrane] (R-HSA-5689049)	0.643	4
UniProt:P49768 PSEN1	6	PSEN1(299-467) [azurophil granule membrane] (R-HSA-6799234) PSEN1(1-467) [plasma membrane] (R-HSA-201606) PSEN1(1-467) [azurophil granule membrane] (R-HSA-6799235) PSEN1(1-298) [azurophil granule membrane] (R-HSA-6799209) PSEN1(1-298) [plasma membrane] (R-HSA-2534298) PSEN1(299-467) [plasma membrane] (R-HSA-2534245)	0.582	4
UniProt:P55040 GEM			0.556	3
UniProt:Q9NX04 CA109			0.556	3
UniProt:Q96PN8 TSSK3			0.556	3
UniProt:Q13064 MKRN3			0.556	3
UniProt:Q13515 BFSP2			0.556	3
UniProt:Q86UW9 DTX2	1	DTX2 [cytosol] (R-HSA-1604436)	0.556	3
UniProt:Q9UBU9 NXF1	2	NXF1 [nucleoplasm] (R-HSA-111690) NXF1 [cytosol] (R-HSA-156481)	0.556	3
UniProt:Q9UI47-2 CTNNA3			0.556	3
UniProt:A2RTX5 SYTC2			0.556	3
UniProt:O15479 MAGB2			0.556	3
UniProt:Q9P0J0 NDUFA13	1	NDUFA13 [mitochondrial inner membrane] (R-HSA-59936)	0.527	2
UniProt:Q66LE6 PPP2R2D	1	PPP2R2D [nucleoplasm] (R-HSA-2160962)	0.527	2
UniProt:P63151 PPP2R2A	2	PPP2R2A [nucleoplasm] (R-HSA-1564978) PPP2R2A [cytosol] (R-HSA-377253)	0.527	2
UniProt:Q9BQP7 MGME1			0.527	2
UniProt:Q9Y285 FARSA	1	FARSA [cytosol] (R-HSA-379667)	0.527	2
UniProt:Q9Y375 NDUFAF1	1	NDUFAF1 [mitochondrial inner membrane] (R-HSA-5689050)	0.527	3
UniProt:Q9NPL8 TIMMDC1	1	TIMMDC1 [mitochondrial inner membrane] (R-HSA-5689720)	0.527	3
UniProt:P03905 MT-ND4	1	MT-ND4 [mitochondrial inner membrane] (R-HSA-60561)	0.527	2
UniProt:O75489 NDUFS3	1	NDUFS3 [mitochondrial matrix] (R-HSA-163927)	0.527	2
UniProt:P49810 PSEN2	2	PSEN2(298-448) [plasma membrane] (R-HSA-9013329) PSEN2(1-297) [plasma membrane] (R-HSA-201599)	0.524	4
UniProt:P02649 APOE	9	APOE [endosome lumen] (R-HSA-174804) APOE [endocytic vesicle lumen] (R-HSA-3221641) APOE [endosome membrane] (R-HSA-174766) APOE [clathrin-coated endocytic vesicle membrane] (R-HSA-174651) APOE [plasma membrane] (R-HSA-174615) APOE [early endosome] (R-HSA-2429687) APOE [extracellular region] (R-HSA-174646) p-APOE [endoplasmic reticulum lumen] (R-HSA-8956980) APOE [endoplasmic reticulum lumen] (R-HSA-6784908)	0.524	4

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