Reactome | CHUK [cytosol]

CHUK [cytosol]

Stable Identifier

R-HSA-168104

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

IKKA, IKK1, Inhibitor of nuclear factor kappa-B kinase alpha subunit

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Locations in the PathwayBrowser

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Cellular responses to stimuli (Homo sapiens)

- Cellular responses to mechanical stimuli (Homo sapiens)
  - Response of endothelial cells to shear stress (Homo sapiens)
    - Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells (Homo sapiens)
      - p-Y397-PTK2 (FAK) phosphorylates CHUK (IKKA) (Homo sapiens)
        
        CHUK:IKBKB:IKBKG [cytosol] (Homo sapiens)
        
        CHUK [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:O15111 CHUK

Gene Names

CHUK, IKKA, TCF16

Chain

chain:1-745

Reference Genes

BioGPS Gene:1147 CHUK

COSMIC (genes):CHUK CHUK

CTD Gene:1147 CHUK

dbSNP Gene:1147 CHUK

ENSEMBL:ENSG00000213341 CHUK

ENSEMBL_homo_sapiens_GENE:ENSG00000213341.11 CHUK

HGNC:1974 CHUK

KEGG Gene (Homo sapiens):1147 CHUK

Monarch:1147 CHUK

NCBI Gene:1147 CHUK

OMIM:600664 CHUK

UCSC:O15111 CHUK

Reference Transcript

RefSeq:NM_001278.4 CHUK

Other Identifiers

1147

11754797_a_at

16717469

209666_PM_s_at

209666_s_at

3303298

3303299

3303301

3303302

3303304

3303309

3303310

3303312

3303314

3303315

3303320

3303321

3303322

3303324

3303325

3303326

3303327

3303328

3303329

3303330

3303331

3303332

3303333

3303334

3303335

3303336

3303337

3303338

33770_at

7935707

A_23_P46748

A_33_P3258141

GE62511

GE81000

GO:0000166

GO:0002376

GO:0003009

GO:0003012

GO:0003824

GO:0004672

GO:0004674

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005886

GO:0006351

GO:0006355

GO:0006468

GO:0006954

GO:0006955

GO:0007249

GO:0007252

GO:0007266

GO:0008384

GO:0008385

GO:0009410

GO:0009615

GO:0009636

GO:0009653

GO:0009898

GO:0009967

GO:0010033

GO:0010034

GO:0010628

GO:0016301

GO:0016310

GO:0016740

GO:0023052

GO:0030154

GO:0032088

GO:0032496

GO:0032727

GO:0033194

GO:0033209

GO:0034142

GO:0034614

GO:0035631

GO:0036211

GO:0038061

GO:0042803

GO:0043123

GO:0043200

GO:0043226

GO:0044877

GO:0045087

GO:0045893

GO:0045944

GO:0046982

GO:0048856

GO:0050877

GO:0050896

GO:0051092

GO:0051146

GO:0061847

GO:0071276

GO:0071356

GO:0097110

GO:0098542

GO:0098586

GO:0140096

GO:1990459

HMNXSV003015828

ILMN_1677041

PH_hs_0011697

TC10002931.hg

g4185272_3p_s_at

Participates

as an input of

as a component of

as an output of

TRAF2,6 ubiquitinates NLRC5 (Homo sapiens)

Other forms of this molecule

p-S176,S180-CHUK [cytosol]

p-T23-CHUK [cytosol]

p-Y187,Y198-CHUK [cytosol]

Inferred To

CHUK [cytosol] (Bos taurus)

CHUK [cytosol] (Canis familiaris)

CHUK [cytosol] (Danio rerio)

CHUK [cytosol] (Drosophila melanogaster)

CHUK [cytosol] (Gallus gallus)

CHUK [cytosol] (Mus musculus)

CHUK [cytosol] (Rattus norvegicus)

CHUK [cytosol] (Sus scrofa)

CHUK [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_001269.3

ZINC - World Drugs

IKKA_HUMAN

Guide to Pharmacology - Targets

1989

OpenTargets

ENSG00000213341

ZINC - FDA approved

IKKA_HUMAN

ZINC - Substances

IKKA_HUMAN

ZINC - Biogenic

IKKA_HUMAN

ZINC target

O15111

PRO

O15111

PDB

5TQX, 3BRT, 5EBZ, 5TQY, 5TQW

ZINC - Investigational

IKKA_HUMAN

IntEnz

2.7.11.10

GeneCards

O15111

HPA

ENSG00000213341-CHUK

Ensembl

ENSG00000213341, ENST00000370397, ENSP00000359424

Pharos - Targets

O15111

Orphanet

24278

ZINC - Predictions - Purchasable

IKKA_HUMAN

HMDB Protein

HMDBP02038

Interactors (25)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y6K9 IKBKG	12	IKBKG D406V [cytosol] (R-HSA-5262943) IKBKG L153R [cytosol] (R-HSA-5262879) IKBKG E391* [cytosol] (R-HSA-5262924) IKBKG C417R [cytosol] (R-HSA-5262858) IKBKG R173G [cytosol] (R-HSA-5262966) IKBKG R175P [cytosol] (R-HSA-5262916) IKBKG 420Wext447 [cytosol] (R-HSA-5262978) monoSUMO1-K277,K309-IKBKG [nucleoplasm] (R-HSA-4755449) IKBKG [nucleoplasm] (R-HSA-4755413) K63polyUb-IKBKG [cytosol] (R-HSA-202530) Ub-285-IKBKG [cytosol] (R-HSA-741397) IKBKG [cytosol] (R-HSA-168108)	0.972	31
UniProt:O14920 IKBKB	3	IKBKB Q432Pfs*62 [cytosol] (R-HSA-9628518) IKBKB [cytosol] (R-HSA-168114) p-S177,S181-IKBKB [cytosol] (R-HSA-202506)	0.956	21
UniProt:P25963 NFKBIA	9	PolyUb-NFKBIA [cytosol] (R-HSA-6782960) NFKBIA [cytosol] (R-HSA-168151) p-S32,S36-NFKBIA [cytosol] (R-HSA-177677) Ub-K21,22-p-S32,S36-NFKBIA [cytosol] (R-HSA-1168581) NFKBIA [nucleoplasm] (R-HSA-4656929) monoSUMO1-K21-NFKBIA [nucleoplasm] (R-HSA-4656935) NFKBIA S32I [cytosol] (R-HSA-5228846) NFKBIA F2_M37del [cytosol] (R-HSA-9630119) NFKBIA M37K [cytosol] (R-HSA-5228805)	0.954	16
UniProt:Q99558 MAP3K14	5	p-T559-MAP3K14 [cytosol] (R-HSA-5668531) K48polyUb-NIK [cytosol] (R-HSA-5668525) Active NIK [cytosol] (R-HSA-5607646) MAP3K14 [cytosol] (R-HSA-168189) p-MAP3K14 [cytosol] (R-HSA-168187)	0.946	14
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.886	9
UniProt:Q13451 FKBP5	2	FKBP5 [cytosol] (R-HSA-5618096) FKBP5 [nucleoplasm] (R-HSA-8939165)	0.784	6
UniProt:P19838 NFKB1	8	NFKB1(1-968) [specific granule lumen] (R-HSA-6799557) NFKB1(1-968) [extracellular region] (R-HSA-6806304) NFKB1(1-968) [secretory granule lumen] (R-HSA-6801004) NFKB1(1-433) [cytosol] (R-HSA-168168) NFKB1(1-433) [nucleoplasm] (R-HSA-177655) NFKB1(1-968) [cytosol] (R-HSA-451607) p-S927,S932-NFKB1(1-968) [cytosol] (R-HSA-451611) 3xUb-p-S927,S932-NFKB1(1-968) [cytosol] (R-HSA-451619)	0.779	4
UniProt:Q04206 RELA	7	MeK310-RELA [nucleoplasm] (R-HSA-8865233) p-S536-RELA [nucleoplasm] (R-HSA-9861499) p-S276,5xAcK-RELA [nucleoplasm] (R-HSA-5660642) p-S276-RELA [nucleoplasm] (R-HSA-5624468) polySUMO3-K37,K122,K123-RELA [nucleoplasm] (R-HSA-4755466) RELA [cytosol] (R-HSA-168172) RELA [nucleoplasm] (R-HSA-177676)	0.669	3
UniProt:P07900 HSP90AA1	8	HSP90AA1 [secretory granule lumen] (R-HSA-6801515) HSP90AA1 [ficolin-1-rich granule lumen] (R-HSA-6801470) HSP90AA1 [plasma membrane] (R-HSA-534996) HSP90AA1 [endocytic vesicle lumen] (R-HSA-3221912) HSP90AA1 [extracellular region] (R-HSA-3221946) HSP90AA1 [nucleoplasm] (R-HSA-5082401) HSP90AA1 [cytosol] (R-HSA-192864) HSP90AA1 [lysosomal lumen] (R-HSA-9622850)	0.669	4
UniProt:O43318 MAP3K7	10	PolyUb-MAP3K7 [cytosol] (R-HSA-6782968) MAP3K7 [plasma membrane] (R-HSA-9012677) K63polyUb-34,158-p-T178,184,187,S192-TAK1 [cytosol] (R-HSA-5607649) K63polyUb-34,158-TAK1 [cytosol] (R-HSA-5607643) p-MAP3K7 [cytosol] (R-HSA-168163) p-T187-MAP3K7 [cytosol] (R-HSA-206014) MAP3K7 [endosome membrane] (R-HSA-450315) p-T184,T187-MAP3K7 [endosome membrane] (R-HSA-450332) MAP3K7 [cytosol] (R-HSA-168156) p-T184,T187-MAP3K7 [cytosol] (R-HSA-202527)	0.65	3
UniProt:P24772 PG200			0.623	3
UniProt:O15111 CHUK	4	CHUK [cytosol] (R-HSA-168104) p-S176,S180-CHUK [cytosol] (R-HSA-177667) p-T23-CHUK [cytosol] (R-HSA-198615) p-Y187,Y198-CHUK [cytosol] (R-HSA-9861501)	0.609	2
UniProt:Q15653 NFKBIB	3	p-S19,S23-Ub-NFKBIB [cytosol] (R-HSA-1168571) p-S19,S23-NFKBIB [cytosol] (R-HSA-177670) NFKBIB [cytosol] (R-HSA-168132)	0.564	3
UniProt:Q7Z406 MYH14	1	MYH14 [cytosol] (R-HSA-419176)	0.564	2
UniProt:P08238 HSP90AB1	6	HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [lysosomal lumen] (R-HSA-9622846)	0.564	3
UniProt:Q86VP1 TAX1BP1	1	TAX1BP1 [cytosol] (R-HSA-937346)	0.544	2
UniProt:Q99759 MAP3K3	1	MAP3K3 [cytosol] (R-HSA-507725)	0.536	2
UniProt:Q6ZSG2 INSY2			0.527	2
UniProt:Q86WI3 NLRC5	2	K63polyUb-NLRC5 [cytosol] (R-HSA-9750938) NLRC5 [cytosol] (R-HSA-937324)	0.524	3
UniProt:Q5TCX8 M3K21			0.524	2
UniProt:Q15796 SMAD2	20	Ub-SMAD2 [cytosol] (R-HSA-6782774) p-S465,S467-SMAD2 P305L [cytosol] (R-HSA-3315471) p-S465,S467-SMAD2 D300A [cytosol] (R-HSA-3315064) p-S465,S467-SMAD2 D300N [cytosol] (R-HSA-3315066) p-S465,S467-SMAD2 A354T [cytosol] (R-HSA-3315474) p-S465,S467-SMAD2 P305Q [cytosol] (R-HSA-3315070) p-S465,S467-SMAD2 D300V [cytosol] (R-HSA-3315067) SMAD2 S464* [cytosol] (R-HSA-3304362) SMAD2 W422* [cytosol] (R-HSA-9668736) SMAD2 S308* [cytosol] (R-HSA-9668732) SMAD2 R427* [cytosol] (R-HSA-9668733) SMAD2 W448* [cytosol] (R-HSA-9668734) SMAD2 S464L [cytosol] (R-HSA-3304383) SMAD2 C463* [cytosol] (R-HSA-9668735) SMAD2 R321* [cytosol] (R-HSA-9668728) SMAD2 S296* [cytosol] (R-HSA-9668729) SMAD2 S306* [cytosol] (R-HSA-9668730) SMAD2 Q455* [cytosol] (R-HSA-9668731) SMAD2 E439* [cytosol] (R-HSA-9668724) SMAD2 L315* [cytosol] (R-HSA-9668725)	0.524	2
UniProt:Q9ULZ3 PYCARD	4	PYCARD [cytosol] (R-HSA-561191) PYCARD [azurophil granule lumen] (R-HSA-6798768) PYCARD [extracellular region] (R-HSA-6806196) PYCARD [secretory granule lumen] (R-HSA-6800957)	0.512	5
UniProt:P71451 INLC			0.509	3
UniProt:P32121 ARRB2	3	ARRB2 [cytosol] (R-HSA-416464) PolyUb-ARRB2 [cytosol] (R-HSA-6783000) ARRB2 [endocytic vesicle membrane] (R-HSA-9910881)	0.483	3
UniProt:P01106 MYC	2	PolyUb-MYC [nucleoplasm] (R-HSA-6783169) MYC [nucleoplasm] (R-HSA-188379)	0.463	3