Reactome | IKBKB [cytosol]

IKBKB [cytosol]

Stable Identifier

R-HSA-168114

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

IKKB, IKK2, IKK-beta, Inhibitor of nuclear factor kappa B kinase beta subunit

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Locations in the PathwayBrowser for interactor UniProt:Q99558 MAP3K14

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External Reference Information

External Reference

UniProt:O14920 IKBKB

Gene Names

IKBKB, IKKB

Chain

chain:1-756

Reference Genes

BioGPS Gene:3551 IKBKB

COSMIC (genes):IKBKB IKBKB

CTD Gene:3551 IKBKB

dbSNP Gene:3551 IKBKB

ENSEMBL:ENSG00000104365 IKBKB

HGNC:5960 IKBKB

KEGG Gene (Homo sapiens):3551 IKBKB

Monarch:3551 IKBKB

NCBI Gene:3551 IKBKB

OMIM:603258 IKBKB

UCSC:O14920 IKBKB

Reference Transcript

Other Identifiers

0006220619

11730928_a_at

11730929_s_at

11730930_a_at

11745356_a_at

11746063_a_at

11746648_a_at

11750345_a_at

11752235_x_at

11753155_x_at

11755411_a_at

11755412_x_at

17068462

209341_s_at

209342_s_at

211027_3p_s_at

211027_s_at

3096093

3096096

3096103

3096105

3096108

3096118

3096119

3096123

3096129

3096130

3096131

3096133

3096134

3096136

3096137

3096142

3096144

3096145

3096146

3096149

3096153

3096157

3096158

3096159

3096160

3096161

3096162

3096163

3096164

3551

35960_at

44812_at

54675_at

54679_g_at

65461_r_at

8146171

A_23_P216188

A_24_P132518

A_24_P155058

GE62527

GO:0000166

GO:0002223

GO:0002376

GO:0002479

GO:0002756

GO:0003674

GO:0004672

GO:0004674

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005634

GO:0005737

GO:0005829

GO:0005886

GO:0006464

GO:0006468

GO:0006950

GO:0006954

GO:0007010

GO:0007165

GO:0007249

GO:0007252

GO:0008150

GO:0008219

GO:0008384

GO:0008385

GO:0009058

GO:0009615

GO:0009898

GO:0010803

GO:0016020

GO:0016032

GO:0016301

GO:0016310

GO:0016740

GO:0018105

GO:0019899

GO:0019901

GO:0022607

GO:0030154

GO:0030866

GO:0032991

GO:0033209

GO:0034330

GO:0034641

GO:0035509

GO:0035631

GO:0035666

GO:0038095

GO:0042325

GO:0042802

GO:0042803

GO:0043066

GO:0043123

GO:0043167

GO:0043226

GO:0044403

GO:0045087

GO:0045121

GO:0045893

GO:0045944

GO:0046982

GO:0048856

GO:0050852

GO:0051092

GO:0051403

GO:0070498

GO:0071356

GO:0072659

GO:0097110

GO:0106310

GO:0106311

GO:1903140

GO:1903347

GO:1990459

HMNXSV003029800

HMNXSV003035882

Hs.226573.0.S3_3p_a_at

Hs.226573.0.S3_3p_x_at

ILMN_1727142

ILMN_2172588

PH_hs_0024951

TC08000325.hg

TC08001896.hg

g4185274_3p_a_at

Participates

as an input of

as a component of

Other forms of this molecule

IKBKB Q432Pfs*62 [cytosol]

p-S177,S181-IKBKB [cytosol]

Inferred To

IKBKB [cytosol] (Bos taurus)

IKBKB [cytosol] (Canis familiaris)

IKBKB [cytosol] (Gallus gallus)

IKBKB [cytosol] (Sus scrofa)

IKKbeta [cytosol] (Drosophila melanogaster)

ikbkb [cytosol] (Danio rerio)

ikbkb [cytosol] (Xenopus tropicalis)

Ikbkb [cytosol] (Mus musculus)

Ikbkb [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_001229707.1, NP_001177649.1, NP_001547.1

ZINC - World Drugs

IKKB_HUMAN

Guide to Pharmacology - Targets

2039

OpenTargets

ENSG00000104365

ZINC - FDA approved

IKKB_HUMAN

ZINC - Substances

IKKB_HUMAN

ZINC - Biogenic

IKKB_HUMAN

ZINC target

O14920

PRO

O14920

GlyGen

O14920

PDB

3BRV, 4E3C, 4KIK, 3BRT

ZINC - Investigational

IKKB_HUMAN

IntEnz

2.7.11.10

GeneCards

O14920

HPA

ENSG00000104365-IKBKB

Ensembl

ENST00000416505, ENST00000520810, ENSP00000497383, ENSP00000404920, ENSG00000104365, ENSP00000430684, ENST00000649612

Pharos - Targets

O14920

Orphanet

22826

ZINC - Predictions - Purchasable

IKKB_HUMAN

HMDB Protein

HMDBP01302

Interactors (29)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y6K9 IKBKG	12	monoSUMO1-K277,K309-IKBKG [nucleoplasm] (R-HSA-4755449) IKBKG [nucleoplasm] (R-HSA-4755413) IKBKG D406V [cytosol] (R-HSA-5262943) IKBKG L153R [cytosol] (R-HSA-5262879) IKBKG E391* [cytosol] (R-HSA-5262924) IKBKG C417R [cytosol] (R-HSA-5262858) IKBKG R173G [cytosol] (R-HSA-5262966) IKBKG R175P [cytosol] (R-HSA-5262916) IKBKG 420Wro447 [cytosol] (R-HSA-5262978) K63polyUb-NEMO [cytosol] (R-HSA-202530) Ub-285-IKBKG [cytosol] (R-HSA-741397) IKBKG [cytosol] (R-HSA-168108)	0.981	37
UniProt:P25963 NFKBIA	10	PolyUb-NFKBIA [cytosol] (R-HSA-6782960) monoSUMO1-K21-NFKBIA [nucleoplasm] (R-HSA-4656935) NFKBIA [cytosol] (R-HSA-168151) p-S32,S36-NFKBIA [cytosol] (R-HSA-177677) K48PolyUb-K21,22-p-S32,S36-IkBA [cytosol] (R-HSA-5607659) Ub-K21,22-p-S32,S36-NFKBIA [cytosol] (R-HSA-1168581) NFKBIA S32I [cytosol] (R-HSA-5228846) NFKBIA F2_M37del [cytosol] (R-HSA-9630119) NFKBIA M37K [cytosol] (R-HSA-5228805) NFKBIA [nucleoplasm] (R-HSA-4656929)	0.969	27
UniProt:O15111 CHUK	3	CHUK [cytosol] (R-HSA-168104) p-S176,S180-CHUK [cytosol] (R-HSA-177667) p-T23-CHUK [cytosol] (R-HSA-198615)	0.949	18
UniProt:Q99558 MAP3K14	5	Active NIK [cytosol] (R-HSA-5607646) MAP3K14 [cytosol] (R-HSA-168189) p-MAP3K14 [cytosol] (R-HSA-168187) K48polyUb-NIK [cytosol] (R-HSA-5668525) p-T559-MAP3K14 [cytosol] (R-HSA-5668531)	0.87	6
UniProt:O14920 IKBKB	3	IKBKB Q432Pfs*62 [cytosol] (R-HSA-9628518) p-S177,S181-IKBKB [cytosol] (R-HSA-202506) IKBKB [cytosol] (R-HSA-168114)	0.869	9
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.744	4
UniProt:P19838 NFKB1	8	NFKB1(1-968) [secretory granule lumen] (R-HSA-6801004) NFKB1(1-968) [extracellular region] (R-HSA-6806304) NFKB1(1-968) [specific granule lumen] (R-HSA-6799557) NFKB1(1-433) [cytosol] (R-HSA-168168) NFKB1(1-433) [nucleoplasm] (R-HSA-177655) NFKB1(1-968) [cytosol] (R-HSA-451607) p-S927,S932-NFKB1(1-968) [cytosol] (R-HSA-451611) 3xUb-p-S927,S932-NFKB1(1-968) [cytosol] (R-HSA-451619)	0.706	3
UniProt:Q04206 RELA	6	polySUMO3-K37,K122,K123-RELA [nucleoplasm] (R-HSA-4755466) MeK310-RELA [nucleoplasm] (R-HSA-8865233) p-S276,5xAcK-RELA [nucleoplasm] (R-HSA-5660642) p-S276-RELA [nucleoplasm] (R-HSA-5624468) RELA [cytosol] (R-HSA-168172) RELA [nucleoplasm] (R-HSA-177676)	0.676	3
UniProt:O43318 MAP3K7	10	PolyUb-MAP3K7 [cytosol] (R-HSA-6782968) MAP3K7 [plasma membrane] (R-HSA-9012677) K63polyUb-34,158-TAK1 [cytosol] (R-HSA-5607643) K63polyUb-34,158-p-T178,184,187,S192-TAK1 [cytosol] (R-HSA-5607649) p-MAP3K7 [cytosol] (R-HSA-168163) p-T187-MAP3K7 [cytosol] (R-HSA-206014) MAP3K7 [endosome membrane] (R-HSA-450315) p-T184,T187-MAP3K7 [endosome membrane] (R-HSA-450332) MAP3K7 [cytosol] (R-HSA-168156) p-T184,T187-MAP3K7 [cytosol] (R-HSA-202527)	0.657	6
UniProt:P67775 PPP2CA	4	MeL-PPP2CA [nucleoplasm] (R-HSA-8857791) p-Y307-PPP2CA [cytosol] (R-HSA-8857939) PPP2CA [cytosol] (R-HSA-165971) PPP2CA [nucleoplasm] (R-HSA-165978)	0.641	3
UniProt:P24772 B14			0.623	3
UniProt:Q9UGK3 STAP2	2	p-Y250-STAP2 [plasma membrane] (R-HSA-8848079) STAP2 [cytosol] (R-HSA-8848028)	0.623	7
UniProt:Q92574 TSC1	2	TSC1 [plasma membrane] (R-HSA-165169) TSC1 [cytosol] (R-HSA-5672338)	0.611	3
UniProt:Q14145 KEAP1	3	Ub-KEAP1 [cytosol] (R-HSA-6782766) ub-KEAP1 [cytosol] (R-HSA-9766647) KEAP1 [cytosol] (R-HSA-976038)	0.61	6
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.609	2
UniProt:P23396 RPS3	2	RPS3 [nucleoplasm] (R-HSA-6798714) RPS3 [cytosol] (R-HSA-72369)	0.602	4
UniProt:Q5D1E7 ZC12A			0.591	4
UniProt:P03409 TAX			0.589	3
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) N [plasma membrane] (R-COV-9694356) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [cytosol] (R-COV-9694300) p-S188,206-N [cytosol] (R-COV-9729324) p-8S-N [cytosol] (R-COV-9729335) p-8S,2T-N [cytosol] (R-COV-9729277) p-11S,2T-N [cytosol] (R-COV-9729264) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340)	0.581	7
UniProt:Q7Z434 MAVS	2	MAVS [mitochondrial outer membrane] (R-HSA-913730) K48polyUb-MAVS [mitochondrial outer membrane] (R-HSA-983463)	0.564	2
UniProt:O14965 AURKA	6	SUMO1-K258-AURKA [cytosol] (R-HSA-4655367) p-T288-AURKA [nucleoplasm] (R-HSA-6805089) AURKA [nucleoplasm] (R-HSA-4655443) PolyUb-AURKA [cytosol] (R-HSA-8854040) AURKA [cytosol] (R-HSA-174254) p-T288-AURKA [cytosol] (R-HSA-2574832)	0.544	2
UniProt:Q00610 CLTC	10	CLTC [plasma membrane] (R-HSA-2980668) CLTC [clathrin-coated endocytic vesicle membrane] (R-HSA-5138450) CLTC [lysosomal membrane] (R-HSA-2980660) CLTC(2-1634)-ALK(1059-1620) fusion [cytosol] (R-HSA-9710853) CLTC(2-1634)-p-7Y ALK(1058-1620) fusion [cytosol] (R-HSA-9710835) CLTC(2-1634)-p-7Y ALK(1059-1620) fusion [cytosol] (R-HSA-9710854) CLTC(2-1634)-ALK(1058-1620) fusion [cytosol] (R-HSA-9710852) CLTC [endolysosome membrane] (R-HSA-8870827) CLTC [cytosol] (R-HSA-8856820) CLTC [trans-Golgi network membrane] (R-HSA-5333703)	0.536	2
UniProt:P08238 HSP90AB1	6	HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [lysosomal lumen] (R-HSA-9622846)	0.536	3
UniProt:Q86WI3 NLRC5	1	NLRC5 [cytosol] (R-HSA-937324)	0.524	2
UniProt:Q9ULZ3 PYCARD	4	PYCARD [cytosol] (R-HSA-561191) PYCARD [azurophil granule lumen] (R-HSA-6798768) PYCARD [extracellular region] (R-HSA-6806196) PYCARD [secretory granule lumen] (R-HSA-6800957)	0.512	4
UniProt:P03230 LMP1			0.499	2
UniProt:Q9UKE5 TNIK	1	TNIK [cytosol] (R-HSA-3214889)	0.499	2
UniProt:Q12933 TRAF2	5	TRAF2 [nucleoplasm] (R-HSA-8862199) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) TRAF2 [cytosol] (R-HSA-66370)	0.483	2
UniProt:Q92793 CREBBP	4	monoSUMO1-K998,K1033,K1056-CREBBP [nucleoplasm] (R-HSA-3927877) FOXO4-S-S-CREBBP [nucleoplasm] (R-HSA-9617684) CREBBP [cytosol] (R-HSA-9756493) CREBBP [nucleoplasm] (R-HSA-193545)	0.483	2

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