Toll Like Receptor 9 (TLR9) Cascade

Stable Identifier
R-HSA-168138
Type
Pathway
Species
Homo sapiens
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CpG DNA is an unusual Pathogen-Associated Molecular Pattern (PAMP). Cytosine methylation exists in mammalian but not bacterial cells, and most (but not all) CpG in the mammalian genome is methylated. Therefore, unmethylated CpG DNA may signal the presence of microbial infection. Evidence of CpG recognition by TLR9 was demonstrated both in human and mouse, and this type of signaling requires its internalization into late endosomal/lysosomal compartments. TLR9 has been reported to be able to discern different types of CpG motifs, and therefore that it presumably recognizes CpG DNA directly. It appears that over evolutionary periods, TLR9 molecules expressed by different species have diverged. This has led to differences in the precise sequence motif (CpG dinucleotide plus flanking regions) that optimally stimulate the innate immune system of different animals.

Literature References
PubMed ID Title Journal Year
14751759 Signal transduction pathways mediated by the interaction of CpG DNA with Toll-like receptor 9

Takeshita, F, Gursel, I, Ishii, KJ, Suzuki, K, Gursel, M, Klinman, DM

Semin Immunol 2004
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