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MAPK8 [cytosol]
Stable Identifier
R-HSA-168141
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
JNK1, mitogen-activated protein kinase 8
Icon
Locations in the PathwayBrowser for interactor UniProt:O14733 MAP2K7
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Parasitic Infection Pathways (Homo sapiens)
Leishmania infection (Homo sapiens)
Killing mechanisms (Homo sapiens)
WNT5:FZD7-mediated leishmania damping (Homo sapiens)
GTP-bound RAC1 contributes to MAPK8 activation (Homo sapiens)
MAPK8 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-1 family signaling (Homo sapiens)
Interleukin-38 signaling (Homo sapiens)
MAPK8 phosphorylation (Homo sapiens)
MAPK8 [cytosol] (Homo sapiens)
Programmed Cell Death (Homo sapiens)
Apoptosis (Homo sapiens)
Intrinsic Pathway for Apoptosis (Homo sapiens)
Activation of BH3-only proteins (Homo sapiens)
Activation of BIM and translocation to mitochondria (Homo sapiens)
Phosphorylation of BIM by JNK (Homo sapiens)
MAPK8 [cytosol] (Homo sapiens)
Activation of BMF and translocation to mitochondria (Homo sapiens)
Phosphorylation of DLC2 by MAPK8 (Homo sapiens)
MAPK8 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Death Receptor Signaling (Homo sapiens)
p75 NTR receptor-mediated signalling (Homo sapiens)
Cell death signalling via NRAGE, NRIF and NADE (Homo sapiens)
NRAGE signals death through JNK (Homo sapiens)
GTP-bound RAC contributes to JNK activation (Homo sapiens)
MAPK8 [cytosol] (Homo sapiens)
NRAGE activates JNK (Homo sapiens)
MAPK8 [cytosol] (Homo sapiens)
NRIF signals cell death from the nucleus (Homo sapiens)
NRIF and TRAF6 may activate JNK (Homo sapiens)
MAPK8 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P45983 MAPK8
Gene Names
MAPK8, JNK1, PRKM8, SAPK1, SAPK1C
Chain
chain:1-427
Reference Genes
COSMIC (genes):MAPK8 MAPK8
dbSNP Gene:5599 MAPK8
ENSEMBL:ENSG00000107643 MAPK8
Participates
as a member of
MAPK8,9 [cytosol] (Homo sapiens)
MAPK8,9,10 [cytosol] (Homo sapiens)
as an input of
GTP-bound RAC1 contributes to MAPK8 activation (Homo sapiens)
NRAGE activates JNK (Homo sapiens)
GTP-bound RAC contributes to JNK activation (Homo sapiens)
NRIF and TRAF6 may activate JNK (Homo sapiens)
MAPK8 phosphorylation (Homo sapiens)
Other forms of this molecule
p-T,Y-MAPK8 [cytosol]
p-T,Y-MAPK8 [nucleoplasm]
Inferred To
Homologues of MAPK8 [cytosol]
(Dictyostelium discoideum)
MAPK8 [cytosol]
(Bos taurus)
MAPK8 [cytosol]
(Caenorhabditis elegans)
MAPK8 [cytosol]
(Canis familiaris)
MAPK8 [cytosol]
(Danio rerio)
MAPK8 [cytosol]
(Dictyostelium discoideum)
MAPK8 [cytosol]
(Drosophila melanogaster)
MAPK8 [cytosol]
(Gallus gallus)
MAPK8 [cytosol]
(Mus musculus)
MAPK8 [cytosol]
(Rattus norvegicus)
MAPK8 [cytosol]
(Saccharomyces cerevisiae)
MAPK8 [cytosol]
(Schizosaccharomyces pombe)
MAPK8 [cytosol]
(Sus scrofa)
Interactors (18)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P05412 JUN
4
JUN [nucleoplasm]
(R-HSA-450250)
p-S63,S73-JUN [nucleoplasm]
(R-HSA-450237)
JUN [cytosol]
(R-HSA-168194)
p-S63,S73-JUN [cytosol]
(R-HSA-8868682)
0.854
5
UniProt:P45984 MAPK9
3
MAPK9 [cytosol]
(R-HSA-450355)
p-T183,Y185-MAPK9 [cytosol]
(R-HSA-450293)
p-T183,Y185-MAPK9 [nucleoplasm]
(R-HSA-450319)
0.773
5
UniProt:Q9UQF2 JIP1
0.708
8
UniProt:P45985 MAP2K4
4
MAP2K4(?-399) [cytosol]
(R-HSA-5211396)
MAP2K4(1-?) [cytosol]
(R-HSA-5211402)
p-S257,T261-MAP2K4 [cytosol]
(R-HSA-168170)
MAP2K4 [cytosol]
(R-HSA-168107)
0.688
3
UniProt:Q13202 DUSP8
2
DUSP8 [nucleoplasm]
(R-HSA-5675349)
DUSP8 [cytosol]
(R-HSA-5675348)
0.659
3
UniProt:O43379 WDR62
0.643
3
UniProt:P27986 PIK3R1
16
PIK3R1 [plasma membrane]
(R-HSA-198365)
PIK3R1 [cytosol]
(R-HSA-74789)
K63polyUb-PIK3R1 [cytosol]
(R-HSA-3080572)
PIK3R1 R574T [plasma membrane]
(R-HSA-2399540)
PIK3R1 R574I [plasma membrane]
(R-HSA-2399536)
PIK3R1 D560H [plasma membrane]
(R-HSA-2399432)
PIK3R1 N564K [plasma membrane]
(R-HSA-2399431)
PIK3R1 K459del [plasma membrane]
(R-HSA-2399554)
PIK3R1 N564D [plasma membrane]
(R-HSA-2399427)
PIK3R1 D560Y [plasma membrane]
(R-HSA-2399421)
PIK3R1 R574_T576del [plasma membrane]
(R-HSA-2399544)
PIK3R1 H450_E451del [plasma membrane]
(R-HSA-2399545)
PIK3R1 Y463_L466del [plasma membrane]
(R-HSA-2399546)
PIK3R1 K379E [plasma membrane]
(R-HSA-8944148)
PIK3R1 G376R [plasma membrane]
(R-HSA-2399717)
p-Y-PIK3R1 [cytosol]
(R-HSA-9680647)
0.623
6
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.553
2
UniProt:O14733-2 MAP2K7
0.544
3
UniProt:P46108 CRK
1
CRK [cytosol]
(R-HSA-2980677)
0.536
2
UniProt:P29401 TKT
1
TKT [cytosol]
(R-HSA-71321)
0.527
2
UniProt:P16104 H2AFX
7
H2AFX [nucleoplasm]
(R-HSA-56151)
p-Y143-H2AFX [nucleoplasm]
(R-HSA-5683942)
p-S140,Y143-H2AFX [nucleoplasm]
(R-HSA-5683953)
p-S140-H2AFX [nucleoplasm]
(R-HSA-75170)
K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm]
(R-HSA-5682847)
H2AFX [extracellular region]
(R-HSA-977583)
Me2sR4-H2AFX [nucleoplasm]
(R-HSA-5218317)
0.524
3
UniProt:Q07817 BCL2L1
2
BCL2L1 [cytosol]
(R-HSA-50771)
BCL2L1 [mitochondrial outer membrane]
(R-HSA-114236)
0.516
2
UniProt:Q8N122 RPTOR
3
p-S722,S792-RPTOR [cytosol]
(R-HSA-3132767)
RPTOR [cytosol]
(R-HSA-3006727)
RPTOR [nucleoplasm]
(R-HSA-5083664)
0.499
6
UniProt:Q9WVI9-1 MAPK8IP1
0.499
2
UniProt:P56747 CLDN6
2
CLDN6 [plasma membrane]
(R-HSA-419992)
CLDN6 [cell junction]
(R-HSA-421250)
0.488
3
UniProt:O14733 MAP2K7
4
MAP2K7(?-419) [cytosol]
(R-HSA-5211401)
MAP2K7(2-?) [cytosol]
(R-HSA-5211389)
MAP2K7 [cytosol]
(R-HSA-450276)
p-S271,T275-MAP2K7 [cytosol]
(R-HSA-450353)
0.483
4
UniProt:P60953 CDC42
3
CDC42 [cytosol]
(R-HSA-442630)
CDC42 [plasma membrane]
(R-HSA-449545)
CDC42 [endoplasmic reticulum membrane]
(R-HSA-5672086)
0.483
2
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