Toll Like Receptor 10 (TLR10) Cascade

Stable Identifier
R-HSA-168142
Type
Pathway
Species
Homo sapiens
Related Species
Escherichia coli
Locations in the PathwayBrowser
Summation

Little is known about TLR10 ligands. It has been established that the receptor homodimerizes upon binding and signals in an MyD88-dependent manner (Hasan U et al 2005; Nyman T et al 2008). It may also heterodimerize with TLRs 1 and 2. It is expressed in a restricted fashion as a highly N-glycosylated protein detectable in B cells and dendritic cells.

Literature References
PubMed ID Title Journal Year
18332149 The crystal structure of the human toll-like receptor 10 cytoplasmic domain reveals a putative signaling dimer

Nyman, T, Stenmark, P, Flodin, S, Johansson, I, Hammarström, M, Nordlund, P

J Biol Chem 2008
15728506 Human TLR10 is a functional receptor, expressed by B cells and plasmacytoid dendritic cells, which activates gene transcription through MyD88

Hasan, U, Chaffois, C, Gaillard, C, Saulnier, V, Merck, E, Tancredi, S, Guiet, C, Briere, F, Vlach, J, Lebecque, S, Trinchieri, G, Bates, EE

J Immunol 2005
Participants
Participant Of
Event Information
Orthologous Events
Cross References
BioModels Database
Authored
Reviewed