Toll Like Receptor 3 (TLR3) Cascade

Stable Identifier
R-HSA-168164
Type
Pathway
Species
Homo sapiens
Related Species
Rotavirus, Influenza A virus, Hepatitis B virus, Hepatitis C Virus, Human herpesvirus 1
Locations in the PathwayBrowser
Summation

Toll-like receptor 3 (TLR3) as was shown for mammals is expressed on myeloid dendritic cells, respiratory epithelium, macrophages, and appears to play a central role in mediating the antiviral and inflammatory responses of the innate immunity in combating viral infections.

Mammalian TLR3 recognizes dsRNA, and that triggers the receptor to induce the activation of NF-kappaB and the production of type I interferons (IFNs). dsRNA-stimulated phosphorylation of two specific TLR3 tyrosine residues (Tyr759 and Tyr858) is essential for initiating TLR3 signaling pathways.

Literature References
PubMed ID Title Journal Year
18202435 Sensing of viral infection and activation of innate immunity by toll-like receptor 3

Vercammen, E, Staal, J, Beyaert, R

Clin Microbiol Rev 2008
19627256 Recent insights into the structure of Toll-like receptors and post-translational modifications of their associated signalling proteins

Carpenter, S, O'Neill, LA

Biochem J 2009
15733829 Transcriptional signaling by double-stranded RNA: role of TLR3

Sen, GC, Sarkar, SN

Cytokine Growth Factor Rev 2005
Participants
Participant Of
Event Information
Orthologous Events
Cross References
BioModels Database
Authored
Reviewed