Toll Like Receptor TLR1:TLR2 Cascade

Stable Identifier
R-HSA-168179
Type
Pathway
Species
Homo sapiens
Related Species
Neisseria meningitidis serogroup B, Chlamydia trachomatis
Locations in the PathwayBrowser
Summation

TLR1 is expressed by monocytes. TLR1 and TLR2 cotranslationally form heterodimeric complexes on the cell surface and in the cytosol. The TLR2:TLR1 complex recognizes Neisserial PorB and Mycobacterial triacylated lipoproteins and peptides, amongst others, triggering up-regulation of nuclear factor-kappaB production and apoptotic cascades. Such cooperation between TLR1 and TLR2 on the cell surface of normal human peripheral blood mononuclear cells, for instance, leads to the activation of pro-inflammatory cytokine secretion (Sandor et al. 2003).

Literature References
PubMed ID Title Journal Year
12975352 Importance of extra- and intracellular domains of TLR1 and TLR2 in NFkappa B signaling

Sandor, F, Latz, E, Re, F, Mandell, L, Repik, G, Golenbock, DT, Espevik, T, Kurt-Jones, EA, Finberg, RW

J Cell Biol 2003
Participants
Participant Of
Event Information
Orthologous Events
Cross References
BioModels Database
Authored
Reviewed