Toll Like Receptor TLR1:TLR2 Cascade

Stable Identifier
R-HSA-168179
Type
Pathway
Species
Homo sapiens
Related Species
Neisseria meningitidis serogroup B, Chlamydia trachomatis
Locations in the PathwayBrowser
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Summation

TLR1 is expressed by monocytes. TLR1 and TLR2 cotranslationally form heterodimeric complexes on the cell surface and in the cytosol. The TLR2:TLR1 complex recognizes Neisserial PorB and Mycobacterial triacylated lipoproteins and peptides, amongst others, triggering up-regulation of nuclear factor-kappaB production and apoptotic cascades. Such cooperation between TLR1 and TLR2 on the cell surface of normal human peripheral blood mononuclear cells, for instance, leads to the activation of pro-inflammatory cytokine secretion (Sandor et al. 2003).

Literature References
PubMed ID Title Journal Year
12975352 Importance of extra- and intracellular domains of TLR1 and TLR2 in NFkappa B signaling

Sandor, F, Latz, E, Re, F, Mandell, L, Repik, G, Golenbock, DT, Espevik, T, Kurt-Jones, EA, Finberg, RW

J Cell Biol 2003
Participants
Events
Participant Of
hasEvent
Event Information
Go Biological Process
toll-like receptor TLR1:TLR2 signaling pathway (0038123)
Orthologous Events
Toll Like Receptor TLR1:TLR2 Cascade (Arabidopsis thaliana)
Toll Like Receptor TLR1:TLR2 Cascade (Bos taurus)
Toll Like Receptor TLR1:TLR2 Cascade (Caenorhabditis elegans)
Toll Like Receptor TLR1:TLR2 Cascade (Canis familiaris)
Toll Like Receptor TLR1:TLR2 Cascade (Danio rerio)
Toll Like Receptor TLR1:TLR2 Cascade (Dictyostelium discoideum)
Toll Like Receptor TLR1:TLR2 Cascade (Drosophila melanogaster)
Toll Like Receptor TLR1:TLR2 Cascade (Gallus gallus)
Toll Like Receptor TLR1:TLR2 Cascade (Mus musculus)
Toll Like Receptor TLR1:TLR2 Cascade (Oryza sativa)
Toll Like Receptor TLR1:TLR2 Cascade (Rattus norvegicus)
Toll Like Receptor TLR1:TLR2 Cascade (Saccharomyces cerevisiae)
Toll Like Receptor TLR1:TLR2 Cascade (Schizosaccharomyces pombe)
Toll Like Receptor TLR1:TLR2 Cascade (Sus scrofa)
Toll Like Receptor TLR1:TLR2 Cascade (Taeniopygia guttata)
Toll Like Receptor TLR1:TLR2 Cascade (Xenopus tropicalis)
Cross References
BioModels Database
Authored
D'Eustachio, P  (2006-04-19)
Gay, NJ  (2006-04-19)
Gale M, Jr  (2006-04-19)
Zwaginga, JJ  (2006-04-19)
Reviewed
D'Eustachio, P  (2006-07-04)