Toll Like Receptor TLR6:TLR2 Cascade

Stable Identifier
R-HSA-168188
Type
Pathway
Species
Homo sapiens
Related Species
Neisseria meningitidis serogroup B, Chlamydia trachomatis
Locations in the PathwayBrowser
Summation

TLR2 and TLR4 recognize different bacterial cell wall components. While TLR4 is trained onto Gram-negative lipopolysaccharide components, TLR2 - in combination with TLR6 - plays a major role in recognizing peptidoglycan wall products from Gram-positive bacteria, as well as Mycobacterial diacylated lipopeptides. In particular, TLR6 appears to participate in discriminating the subtle differences between dipalmitoyl and tripalmitoyl cysteinyl residues (Okusawa et al. 2004).

Literature References
PubMed ID Title Journal Year
14977973 Relationship between structures and biological activities of mycoplasmal diacylated lipopeptides and their recognition by toll-like receptors 2 and 6

Okusawa, T, Fujita, M, Nakamura, J, Into, T, Yasuda, M, Yoshimura, A, Hara, Y, Hasebe, A, Golenbock, DT, Morita, M, Kuroki, Y, Ogawa, T, Shibata, K

Infect Immun 2004
Participants
Participant Of
Event Information
Orthologous Events
Cross References
BioModels Database
Authored
Reviewed