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MAP3K14 [cytosol]
Stable Identifier
R-HSA-168189
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
NIK, Mitogen-activated protein kinase kinase kinase 14, NF-kB inducing kinase
Icon
Locations in the PathwayBrowser for interactor UniProt:P18124 RPL7
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Costimulation by the CD28 family (Homo sapiens)
CD28 co-stimulation (Homo sapiens)
CD28 dependent PI3K/Akt signaling (Homo sapiens)
p-S400-Cot phosphorylates NIK (Homo sapiens)
MAP3K14 [cytosol] (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
TNFR2 non-canonical NF-kB pathway (Homo sapiens)
NIK-->noncanonical NF-kB signaling (Homo sapiens)
Activation of NIK (Homo sapiens)
MAP3K14 [cytosol] (Homo sapiens)
NIK autophosphorylates on T559 (Homo sapiens)
MAP3K14 [cytosol] (Homo sapiens)
Protesomal degradation of K48polyUb-TRAF3 (Homo sapiens)
MAP3K14 [cytosol] (Homo sapiens)
Innate Immune System (Homo sapiens)
C-type lectin receptors (CLRs) (Homo sapiens)
CLEC7A (Dectin-1) signaling (Homo sapiens)
Dectin-1 mediated noncanonical NF-kB signaling (Homo sapiens)
Activation of NIK (Homo sapiens)
MAP3K14 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q99558 MAP3K14
Gene Names
MAP3K14, NIK
Chain
chain:1-947
Reference Genes
BioGPS Gene:9020 MAP3K14
COSMIC (genes):MAP3K14 MAP3K14
CTD Gene:9020 MAP3K14
dbSNP Gene:9020 MAP3K14
ENSEMBL:ENSG00000006062 MAP3K14
ENSEMBL_homo_sapiens_GENE:ENSG00000006062.18 MAP3K14
HGNC:6853 MAP3K14
KEGG Gene (Homo sapiens):9020 MAP3K14
Monarch:9020 MAP3K14
NCBI Gene:9020 MAP3K14
OMIM:604655 MAP3K14
UCSC:Q99558 MAP3K14
Reference Transcript
RefSeq:NM_003954.4 MAP3K14
RefSeq:XM_011525441.2 MAP3K14
Other Identifiers
11724902_a_at
11724903_a_at
16845876
205192_PM_at
205192_at
3759702
3759703
3759705
3759706
3759707
3759708
3759709
3759710
3759712
3759713
3759717
3759719
3759720
3759721
3759722
3759730
3759732
3759733
3759734
3759735
3759736
3759737
3759740
3759741
3759749
3759752
8016194
9020
974_at
A_23_P207319
GE60277
GO:0000165
GO:0000166
GO:0001650
GO:0002376
GO:0003824
GO:0004672
GO:0004674
GO:0004709
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005730
GO:0005737
GO:0005829
GO:0006468
GO:0006955
GO:0007249
GO:0016301
GO:0016310
GO:0016740
GO:0023052
GO:0036211
GO:0038061
GO:0043226
GO:0043231
GO:0051607
GO:0071260
GO:0098542
GO:0106310
GO:0140096
HMNXSV003030142
ILMN_1724070
PH_hs_0025776
TC17001598.hg
Y10256_at
g4505396_3p_at
p33461
Participates
as an input of
NIK autophosphorylates on T559 (Homo sapiens)
Activation of NIK (Homo sapiens)
p-S400-Cot phosphorylates NIK (Homo sapiens)
as an output of
Protesomal degradation of K48polyUb-TRAF3 (Homo sapiens)
as a component of
K48polyUb-TRAF3:NIK [cytosol] (Homo sapiens)
TRAF3:NIK [cytosol] (Homo sapiens)
Other forms of this molecule
p-T559-MAP3K14 [cytosol]
K48polyUb-NIK [cytosol]
Active NIK [cytosol]
p-MAP3K14 [cytosol]
Inferred To
MAP3K14 [cytosol]
(Bos taurus)
MAP3K14 [cytosol]
(Canis familiaris)
MAP3K14 [cytosol]
(Gallus gallus)
MAP3K14 [cytosol]
(Mus musculus)
MAP3K14 [cytosol]
(Saccharomyces cerevisiae)
MAP3K14 [cytosol]
(Sus scrofa)
MAP3K14 [cytosol]
(Xenopus tropicalis)
Ghost homologue of MAP3K14 [cytosol]
(Danio rerio)
Map3k14 [cytosol]
(Rattus norvegicus)
Cross References
RefSeq
NP_003945.2
,
XP_011523743.1
Guide to Pharmacology - Targets
2074
OpenTargets
ENSG00000006062
ZINC - Substances
M3K14_HUMAN
ZINC target
Q99558
ZINC - Biogenic
M3K14_HUMAN
PRO
Q99558
PDB
4IDV
,
6Z1T
,
4DN5
,
4IDT
,
8YHW
,
6Z1Q
,
6WPP
,
4G3D
GeneCards
Q99558
HPA
ENSG00000006062-MAP3K14
Ensembl
ENSP00000478552
,
ENST00000617331
,
ENST00000344686
,
ENSP00000482657
,
ENSG00000006062
,
ENST00000376926
,
ENSP00000480974
Pharos - Targets
Q99558
ZINC - Predictions - Purchasable
M3K14_HUMAN
Orphanet
23729
HMDB Protein
HMDBP01177
Interactors (46)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O15111 CHUK
4
CHUK [cytosol]
(R-HSA-168104)
p-S176,S180-CHUK [cytosol]
(R-HSA-177667)
p-T23-CHUK [cytosol]
(R-HSA-198615)
p-Y187,Y198-CHUK [cytosol]
(R-HSA-9861501)
0.946
14
UniProt:Q13114 TRAF3
4
TRAF3 R118W [cytosol]
(R-HSA-5602321)
K48polyUb-TRAF3 [cytosol]
(R-HSA-936556)
TRAF3 [cytosol]
(R-HSA-914241)
K63polyUb-TRAF3 [cytosol]
(R-HSA-936402)
0.918
10
UniProt:O14920 IKBKB
3
IKBKB Q432Pfs*62 [cytosol]
(R-HSA-9628518)
IKBKB [cytosol]
(R-HSA-168114)
p-S177,S181-IKBKB [cytosol]
(R-HSA-202506)
0.904
7
UniProt:Q16543 CDC37
1
CDC37 [cytosol]
(R-HSA-1221609)
0.813
6
UniProt:P08238 HSP90AB1
6
HSP90AB1 [secretory granule lumen]
(R-HSA-6801477)
HSP90AB1 [extracellular region]
(R-HSA-6806463)
HSP90AB1 [ficolin-1-rich granule lumen]
(R-HSA-6801491)
HSP90AB1 [cytosol]
(R-HSA-419617)
HSP90AB1 [nucleoplasm]
(R-HSA-5082399)
HSP90AB1 [lysosomal lumen]
(R-HSA-9622846)
0.758
6
UniProt:Q12933 TRAF2
5
TRAF2 [nucleoplasm]
(R-HSA-8862199)
K63polyUb-TRAF2 [nucleoplasm]
(R-HSA-8862194)
K63polyUb-TRAF2 [cytosol]
(R-HSA-8862193)
PolyUb-TRAF2 [cytosol]
(R-HSA-6782848)
TRAF2 [cytosol]
(R-HSA-66370)
0.749
9
UniProt:Q9Y6K9 IKBKG
12
IKBKG D406V [cytosol]
(R-HSA-5262943)
IKBKG L153R [cytosol]
(R-HSA-5262879)
IKBKG E391* [cytosol]
(R-HSA-5262924)
IKBKG C417R [cytosol]
(R-HSA-5262858)
IKBKG R173G [cytosol]
(R-HSA-5262966)
IKBKG R175P [cytosol]
(R-HSA-5262916)
IKBKG *420Wext*447 [cytosol]
(R-HSA-5262978)
monoSUMO1-K277,K309-IKBKG [nucleoplasm]
(R-HSA-4755449)
IKBKG [nucleoplasm]
(R-HSA-4755413)
K63polyUb-IKBKG [cytosol]
(R-HSA-202530)
Ub-285-IKBKG [cytosol]
(R-HSA-741397)
IKBKG [cytosol]
(R-HSA-168108)
0.744
5
UniProt:P07900 HSP90AA1
8
HSP90AA1 [secretory granule lumen]
(R-HSA-6801515)
HSP90AA1 [ficolin-1-rich granule lumen]
(R-HSA-6801470)
HSP90AA1 [plasma membrane]
(R-HSA-534996)
HSP90AA1 [endocytic vesicle lumen]
(R-HSA-3221912)
HSP90AA1 [extracellular region]
(R-HSA-3221946)
HSP90AA1 [nucleoplasm]
(R-HSA-5082401)
HSP90AA1 [cytosol]
(R-HSA-192864)
HSP90AA1 [lysosomal lumen]
(R-HSA-9622850)
0.744
5
UniProt:P27708 CAD
1
CAD [cytosol]
(R-HSA-73452)
0.669
3
UniProt:Q00653 NFKB2
6
monoSUMO1-K90,K298,K689,K863-NFKB2(1-900) [cytosol]
(R-HSA-4755500)
NFKB2(1-900) [cytosol]
(R-HSA-2677931)
K48-polyUb-p-7S-p100 [cytosol]
(R-HSA-5607636)
p-7S-p100 [cytosol]
(R-HSA-5607629)
NFKB2(1-454) [cytosol]
(R-HSA-168144)
NFKB2(1-454) [nucleoplasm]
(R-HSA-177674)
0.643
4
UniProt:Q9Y5L4 TIMM13
2
TIMM13 [mitochondrial intermembrane space]
(R-HSA-1307781)
4xHC-TIMM13 [mitochondrial intermembrane space]
(R-HSA-1252199)
0.643
4
UniProt:P61353 RPL27
1
RPL27 [cytosol]
(R-HSA-72440)
0.564
3
UniProt:P36578 RPL4
1
RPL4 [cytosol]
(R-HSA-72474)
0.564
3
UniProt:P62424 RPL7A
1
RPL7A [cytosol]
(R-HSA-72488)
0.564
3
UniProt:P62269 RPS18
2
RPS18 [nucleoplasm]
(R-HSA-6798701)
RPS18 [cytosol]
(R-HSA-72341)
0.564
2
UniProt:P50914 RPL14
1
RPL14 [cytosol]
(R-HSA-72414)
0.564
3
UniProt:P62280 RPS11
2
RPS11 [nucleoplasm]
(R-HSA-6791212)
RPS11 [cytosol]
(R-HSA-72327)
0.564
3
UniProt:P26373 RPL13
1
RPL13 [cytosol]
(R-HSA-72410)
0.564
3
UniProt:P27635 RPL10
1
RPL10 [cytosol]
(R-HSA-72402)
0.564
3
UniProt:Q07020 RPL18
1
RPL18 [cytosol]
(R-HSA-72420)
0.564
3
UniProt:P62847 RPS24
2
RPS24 [nucleoplasm]
(R-HSA-6791186)
RPS24 [cytosol]
(R-HSA-72355)
0.564
2
UniProt:P17066 HSPA6
5
HSPA6 [cytosol]
(R-HSA-3371521)
HSPA6 [nucleoplasm]
(R-HSA-5252088)
HSPA6 [secretory granule lumen]
(R-HSA-6801472)
HSPA6 [extracellular region]
(R-HSA-6806500)
HSPA6 [ficolin-1-rich granule lumen]
(R-HSA-6801512)
0.564
3
UniProt:P62829 RPL23
1
RPL23 [cytosol]
(R-HSA-72430)
0.564
3
UniProt:P62906 RPL10A
1
RPL10A [cytosol]
(R-HSA-72404)
0.564
3
UniProt:P52272 HNRNPM
1
HNRNPM [nucleoplasm]
(R-HSA-71949)
0.564
3
UniProt:P62277 RPS13
2
RPS13 [nucleoplasm]
(R-HSA-6791198)
RPS13 [cytosol]
(R-HSA-72331)
0.564
3
UniProt:P62910 RPL32
1
RPL32 [cytosol]
(R-HSA-72456)
0.564
3
UniProt:P83731 RPL24
1
RPL24 [cytosol]
(R-HSA-72434)
0.564
3
UniProt:Q02878 RPL6
1
RPL6 [cytosol]
(R-HSA-72484)
0.564
3
UniProt:P11142 HSPA8
10
Me3K561-HSPA8 [nucleoplasm]
(R-HSA-8932217)
HSPA8 [secretory granule lumen]
(R-HSA-6801530)
HSPA8 [extracellular region]
(R-HSA-6805936)
HSPA8 [ficolin-1-rich granule lumen]
(R-HSA-6801494)
HSPA8 [nucleoplasm]
(R-HSA-5082380)
HSPA8 [plasma membrane]
(R-HSA-936508)
HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
(R-HSA-888599)
HSPA8 [late endosome lumen]
(R-HSA-9631104)
HSPA8 [lysosomal lumen]
(R-HSA-9625182)
HSPA8 [cytosol]
(R-HSA-264476)
0.564
3
UniProt:Q96L21 RPL10L
1
RPL10L [cytosol]
(R-HSA-8868799)
0.564
3
UniProt:P32969 RPL9
1
RPL9 [cytosol]
(R-HSA-72492)
0.564
3
UniProt:O95816 BAG2
1
BAG2 [cytosol]
(R-HSA-5255445)
0.564
3
UniProt:P18124 RPL7
1
RPL7 [cytosol]
(R-HSA-72486)
0.564
3
UniProt:P39023 RPL3
1
RPL3 [cytosol]
(R-HSA-72448)
0.564
3
UniProt:Q3ZCQ8 TIMM50
1
TIMM50 [mitochondrial inner membrane]
(R-HSA-1252070)
0.564
2
UniProt:P62917 RPL8
3
3OHH216-RPL8 [nucleoplasm]
(R-HSA-9630976)
RPL8 [nucleoplasm]
(R-HSA-9630985)
RPL8 [cytosol]
(R-HSA-72490)
0.564
3
UniProt:P01112 HRAS
20
HRAS Q61R [plasma membrane]
(R-HSA-6802458)
HRAS Q61L [plasma membrane]
(R-HSA-6802452)
HRAS Q61K [plasma membrane]
(R-HSA-6802442)
HRAS G13R [plasma membrane]
(R-HSA-6802368)
HRAS G12V [plasma membrane]
(R-HSA-6802350)
HRAS G12S [plasma membrane]
(R-HSA-6802343)
HRAS T58I [plasma membrane]
(R-HSA-9656014)
HRAS G13C [plasma membrane]
(R-HSA-9656008)
HRAS K117R [plasma membrane]
(R-HSA-9656010)
HRAS G13V [plasma membrane]
(R-HSA-9656579)
HRAS G13D [plasma membrane]
(R-HSA-9656572)
HRAS G13S [plasma membrane]
(R-HSA-9656574)
HRAS K117N [plasma membrane]
(R-HSA-9656603)
HRAS G12D [plasma membrane]
(R-HSA-9656564)
HRAS G12C [plasma membrane]
(R-HSA-9656561)
HRAS [plasma membrane]
(R-HSA-62717)
S-Farn-Me HRAS [plasma membrane]
(R-HSA-9665052)
S-Farn-Me PalmS HRAS [Golgi membrane]
(R-HSA-9647896)
S-Farn-Me HRAS [endoplasmic reticulum membrane]
(R-HSA-9647796)
S-Farn-HRAS [endoplasmic reticulum membrane]
(R-HSA-9647788)
0.556
3
UniProt:Q60680-2 CHUK
0.544
3
UniProt:Q9Y4K3 TRAF6
8
K48polyUb-TRAF6 [cytosol]
(R-HSA-6783233)
PolyUb-TRAF6 [cytosol]
(R-HSA-6782845)
TRAF6 [endosome membrane]
(R-HSA-450272)
K63polyUb-TRAF6 [endosome membrane]
(R-HSA-450227)
TRAF6 [cytosol]
(R-HSA-166366)
K63polyUb-TRAF6 [cytosol]
(R-HSA-2685681)
K63polyUb-TRAF6 [plasma membrane]
(R-HSA-936980)
TRAF6 [plasma membrane]
(R-HSA-936955)
0.536
2
UniProt:Q9Y5A9 YTHD2
0.527
2
UniProt:Q7L2E3 DHX30
0.527
2
UniProt:Q58FG0 HS905
0.527
2
UniProt:Q9Y5J9 TIMM8B
2
TIMM8B [mitochondrial intermembrane space]
(R-HSA-1307790)
4xHC-TIMM8B [mitochondrial intermembrane space]
(R-HSA-1252067)
0.527
2
UniProt:O60220 TIMM8A
2
TIMM8A [mitochondrial intermembrane space]
(R-HSA-1307780)
4xHC-TIMM8A [mitochondrial intermembrane space]
(R-HSA-1252065)
0.527
2
UniProt:Q14974 KPNB1
5
KPNB1 [specific granule lumen]
(R-HSA-6799646)
KPNB1 [extracellular region]
(R-HSA-6806306)
KPNB1 [ficolin-1-rich granule lumen]
(R-HSA-6800978)
KPNB1 [nucleoplasm]
(R-HSA-180714)
KPNB1 [cytosol]
(R-HSA-180733)
0.499
2
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