Export of Viral Ribonucleoproteins from Nucleus

Stable Identifier
R-HSA-168274
Type
Pathway
Species
Homo sapiens
Related Species
Influenza A virus
Locations in the PathwayBrowser
Summation

Influenza genomic RNA (vRNA), synthesized in the nucleus of the infected host cell, is packaged into ribonucleoprotein (RNP) complexes containing viral polymerase proteins and NP (nucleocapsid). NP trimers bind the sugar phosphate backbone of the vRNA. As influenza viral RNP complexes are too large for passive diffusion out of the nucleus, utilization of the cellular nuclear export machinery is achieved by viral adaptor proteins. Matrix protein (M1) is critical for export of the complex from the nucleus, mediating the interaction of the RNP complex with the viral NEP/NS2 protein, which in turn interacts with host cell CRM1/exportin-1 nuclear export protein (Martin, 1991; O'Neill, 1998; Neumann et al., 2000; Elton, 2001; Cros, 2003; Ye, 2006; reviewed in Boulo, 2006).

Literature References
PubMed ID Title Journal Year
11118210 Influenza A virus NS2 protein mediates vRNP nuclear export through NES-independent interaction with hCRM1

Neumann, G, Hughes, MT, Kawaoka, Y

EMBO J 2000
17081640 Nuclear traffic of influenza virus proteins and ribonucleoprotein complexes

Boulo, S, Akarsu, H, Ruigrok, RW, Baudin, F

Virus Res 2006
16806605 Influenza A virus and the cell nucleus

Amorim, MJ, Digard, P

Vaccine 2006
Participants
Participant Of
Event Information
Disease
Name Identifier Synonyms
influenza 8469 Influenza with other manifestations (disorder), Influenza with other manifestations NOS (disorder), flu, Influenza with other manifestations, Influenza with non-respiratory manifestation (disorder), influenza with non-respiratory manifestation
Authored
Reviewed