Reactome: A Curated Pathway Database

NS1 Mediated Effects on Host Pathways

Stable Identifier
R-HSA-168276
Type
Pathway
Species
Homo sapiens
Related Species
Influenza A virus
Locations in the PathwayBrowser
Summation

Viral NS1 protein is a nuclear, dimeric protein that is highly expressed in infected cells and has dsRNA-binding activity. The RNA-binding domain lies within the N-terminal portion of the protein. The NS1 RNA-binding domain forms a symmetric homodimer with a six-helical fold. Mutational analysis has demonstrated that dimer formation is crucial for RNA-binding. The basic residues are believed to make contact with the phosphate backbone of the RNA which is consistent with an observed lack of sequence specificity. Neither NS1 nor its bound RNA undergo any significant structural changes upon binding. The NS1 dimer spans the minor groove of canonical A-form dsRNA. The non-RNA binding portion of NS1 has been termed the effector domain and includes binding sites for host cell poly (A)-binding protein II (PABII) and the 30kDa subunit of cleavage and polyadenylation specificity factor (CPSF).

Literature References
PubMed ID Title Journal Year
0 Orthomyxoviridae: The Viruses and Their Replication Fields Virology, 5th edition D.M. Knipe and P.M. Howley, Editors. 2006, Lippencott Williams and Wilkins: Philadelphia ISBN-10: 0-7817-6060-7 2001
Participants
Participant Of
Disease
Diseases
Name Identifier Synonyms
influenza 8469 Influenza with other manifestations (disorder), Influenza with other manifestations NOS (disorder), flu, Influenza with other manifestations, Influenza with non-respiratory manifestation (disorder), influenza with non-respiratory manifestation