NEP/NS2 Interacts with the Cellular Export Machinery

Stable Identifier
R-HSA-168333
Type
Pathway
Species
Homo sapiens
Related Species
Influenza A virus
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The viral RNP complex is exported from the nucleus via the host cell CRM1 export pathway (Fukuda, 1997; Neumann, 2000; reviewed in Buolo, 2006). The vRNP complex does not interact directly with CRM1 to form an export complex. Rather, an additional viral protein, nuclear export protein (NEP/NS2), acts as an adaptor, binding the viral matrix M1 protein and CRM1, thus linking the viral RNP with CRM1 (Martin, 1991; O'Neill, 1998; Neumann, 2000; Akarsu, 2003). The CRM1/exportin-1 complex recruits additional host cell proteins, and traverses the nuclear pore into the cytosol.

Literature References
PubMed ID Title Journal Year
11118210 Influenza A virus NS2 protein mediates vRNP nuclear export through NES-independent interaction with hCRM1

Neumann, G, Hughes, MT, Kawaoka, Y

EMBO J 2000
17081640 Nuclear traffic of influenza virus proteins and ribonucleoprotein complexes

Boulo, S, Akarsu, H, Ruigrok, RW, Baudin, F

Virus Res 2006
12970177 Crystal structure of the M1 protein-binding domain of the influenza A virus nuclear export protein (NEP/NS2)

Akarsu, H, Burmeister, WP, Petosa, C, Petit, I, Muller, CW, Ruigrok, RW, Baudin, F

EMBO J 2003
Participants
Participant Of
Event Information
Disease
Name Identifier Synonyms
influenza 8469 Influenza with other manifestations (disorder), Influenza with other manifestations NOS (disorder), flu, Influenza with other manifestations, Influenza with non-respiratory manifestation (disorder), influenza with non-respiratory manifestation
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Reviewed
Created