Docking and transport of the RNP:Karyopherin complex through the nuclear pore

Stable Identifier
R-HSA-168337
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Influenza A virus
Compartment
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These RNPs (10-20nm wide) are too large to passively diffuse into the nucleus and therefore, once released from an incoming particle they must rely on the active import mechanism of the host cell nuclear pore complex (NPC). Once the RNP heterodimeric karyopherin complex docks at the NPC, it is transported into the nucleus.

Literature References
PubMed ID Title Journal Year
1985200 Two signals mediate nuclear localization of influenza virus (A/WSN/33) polymerase basic protein 2

Mukaigawa, J, Nayak, DP

J Virol 1991
Participants
Participant Of
Event Information
This event is regulated
Disease
Name Identifier Synonyms
influenza 8469 Influenza with other manifestations (disorder), Influenza with other manifestations NOS (disorder), flu, Influenza with other manifestations, Influenza with non-respiratory manifestation (disorder), influenza with non-respiratory manifestation
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Reviewed
Created