Reactome | MDP elicits a NOD2 response

MDP elicits a NOD2 response

Stable Identifier

R-HSA-168412

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Muramyl dipeptide (MDP) is an essential structural component of bacterial peptidoglycan (PGN) and the minimal elicitor recognized by NOD2. As MDP is present in nearly all bacteria NOD2 is a general sensor of bacteria. NOD2 has additionally been reported to respond to ssRNA (Sabbah et al. 2009) and play a role in T cell activation (Shaw et al. 2011).

Literature References

PubMed ID	Title	Journal	Year
12514169	Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's disease Crespo, J, Pons, F, Nunez, G, Moran, AP, Inohara, N, Inamura, S, Fernandez-Luna, JL, Gutierrez, O, Fontalba, A, Kusumoto, S, Foster, SJ, Hashimoto, M, Ogura, Y, Fukase, K	J Biol Chem	2003
12527755	Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection Labigne, A, Girardin, SE, Viala, J, Philpott, DJ, Boneca, IG, Chamaillard, M, Thomas, G, Sansonetti, PJ	J Biol Chem	2003