Binding of NS1 to cleavage and host polyadenylation specificity factor (CPSF)

Stable Identifier
R-HSA-168859
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Influenza A virus
Compartment
ReviewStatus
5/5
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General
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Influenza virus's non-structural protein (NS1) binds to the host cell's cleavage and host polyadenylation specificity factor (CPSF), inhibiting the ability of CPSF to bind to pre-mRNAs and thus preventing efficient 3' end processing and export of host cell mRNAs out of the nucleus.
Participants
Participates
Event Information
Disease
Name Identifier Synonyms
influenza DOID:8469 Influenza with other manifestations (disorder), Influenza with other manifestations NOS (disorder), flu, Influenza with other manifestations, Influenza with non-respiratory manifestation (disorder), influenza with non-respiratory manifestation
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Reviewed
Created
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