Reactome | Binding of NS1 to cleavage and host polyadenylation specificity factor (CPSF)

Binding of NS1 to cleavage and host polyadenylation specificity factor (CPSF)

Stable Identifier

R-HSA-168859

Type

Reaction [binding]

Species

Homo sapiens

Related Species

Influenza A virus

Compartment

nucleoplasm

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Binding of NS1 to cleavage and host polyadenylation specificity factor (CPSF)

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Influenza virus's non-structural protein (NS1) binds to the host cell's cleavage and host polyadenylation specificity factor (CPSF), inhibiting the ability of CPSF to bind to pre-mRNAs and thus preventing efficient 3' end processing and export of host cell mRNAs out of the nucleus.

Literature References

PubMed ID	Title	Journal	Year
9986787	Influenza virus inhibits cleavage of the HSP70 pre-mRNAs at the polyadenylation site Shimizu, K, Iguchi, A, Gomyou, R, Ono, Y	Virology	1999
11421366	The 3'-end-processing factor CPSF is required for the splicing of single-intron pre-mRNAs in vivo Li, Y, Chen, ZY, Wang, W, Baker, CC, Krug, RM	RNA	2001
12667806	Cellular antiviral responses against influenza A virus are countered at the posttranscriptional level by the viral NS1A protein via its binding to a cellular protein required for the 3' end processing of cellular pre-mRNAS Noah, DL, Twu, KY, Krug, RM	Virology	2003
9651582	Influenza virus NS1 protein interacts with the cellular 30 kDa subunit of CPSF and inhibits 3'end formation of cellular pre-mRNAs Nemeroff, ME, Barabino, SM, Li, Y, Keller, W, Krug, RM	Mol Cell	1998

Participants

Input

Output

CPSF:NS1 Complex [nucleoplasm] (Homo sapiens)

Participant Of

hasEvent

Inhibition of Host mRNA Processing and RNA Silencing

Event Information

Go Biological Process

modification by virus of host mRNA processing (0046778)

Disease

Name	Identifier	Synonyms
influenza	8469	Influenza with other manifestations (disorder), Influenza with other manifestations NOS (disorder), flu, Influenza with other manifestations, Influenza with non-respiratory manifestation (disorder), influenza with non-respiratory manifestation

Authored

Gillespie, ME (2013-11-18)

Reviewed

Gale M, Jr (2004-05-12)

Created