NA activation of TGF-beta

Stable Identifier
R-HSA-168865
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Influenza A virus
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
NA activation of TGF-beta
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Influenza A virus induces apoptosis in a variety of ways including by activation of host TGF-beta by viral neuraminidase (NA).

Literature References
PubMed ID Title Journal Year
25535343 Influenza viral neuraminidase primes bacterial coinfection through TGF-β-mediated expression of host cell receptors

Li, N, Ren, A, Wang, X, Fan, X, Zhao, Y, Gao, GF, Cleary, P, Wang, B

Proc. Natl. Acad. Sci. U.S.A. 2015
9934696 Role of neuraminidase in influenza virus-induced apoptosis

Morris, SJ, Price, GE, Barnett, JM, Hiscox, SA, Smith, H, Sweet, C

J Gen Virol 1999
Participants
Input
Output
Participant Of
hasEvent
Event Information
Go Biological Process
induction of host immune response by virus (0046730)
Catalyst Activity
Catalyst Activity
Title
peptidase activator activity of NA [extracellular region]
Physical Entity
NA [extracellular region]
Activity
peptidase activator activity (0016504)
Disease
Name Identifier Synonyms
influenza 8469 Influenza with other manifestations (disorder), Influenza with other manifestations NOS (disorder), flu, Influenza with other manifestations, Influenza with non-respiratory manifestation (disorder), influenza with non-respiratory manifestation
Authored
Gillespie, ME  (2013-11-18)
Reviewed
Gale M, Jr  (2004-05-12)
Created
Cite Us!