Trimerization of HA

Stable Identifier
R-HSA-168875
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Influenza A virus
Compartment
endoplasmic reticulum membrane
ReviewStatus
5/5
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Trimerization of HA
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Trimerisation of the fully folded and fully oxidised HA monomer is thought to occur in the endoplasmic reticulum and ERGIC compartment, following dissociation of HA from calnexin. Trimerisation is generally thought to be the final step in HA maturation occurring in the endoplasmic reticulum before transport to the Golgi apparatus, although Yewdell et al (1988) provide data suggesing that trimerisation may occur within the Golgi.
Literature References
PubMed ID Title Journal Year
8460475 Folding and assembly of viral membrane proteins

Doms, RW, Lamb, RA, Rose, JK, Helenius, A

Virology 1993
7729412 Folding and oligomerization of influenza hemagglutinin in the ER and the intermediate compartment

Tatu, U, Hammond, C, Helenius, A

EMBO J 1995
3757030 Expression of wild-type and mutant forms of influenza hemagglutinin: the role of folding in intracellular transport

Gething, MJ, McCammon, K, Sambrook, J

Cell 1986
Participants
Input
Output
Participates
as an event of
Event Information
Go Biological Process
viral protein processing (0019082)
Disease
Name Identifier Synonyms
influenza DOID:8469 Influenza with other manifestations (disorder), Influenza with other manifestations NOS (disorder), flu, Influenza with other manifestations, Influenza with non-respiratory manifestation (disorder), influenza with non-respiratory manifestation
Cross References
Mondo
Authored
Steel, J  (2007-05-01)
Reviewed
Squires, B  (2007-05-01)
Rush, MG  (2007-05-01)
Created
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