PB1-F2 binds to the mitochondrial adenine nucleotide translocator 3 ANT3, inducing apoptosis

Stable Identifier
R-HSA-168878
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Influenza A virus
Compartment
mitochondrial inner membrane, mitochondrial intermembrane space
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PB1-F2 binds to the mitochondrial adenine nucleotide translocator 3 ANT3, inducing apoptosis
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Influenza A virus induces apoptosis in a variety of ways including binding of viral PB1-F2 to host mitochondrial adenine nucleotide translocator 3 (ANT3).

Literature References
PubMed ID Title Journal Year
15163724 PB1-F2, an influenza A virus-encoded proapoptotic mitochondrial protein, creates variably sized pores in planar lipid membranes

Chanturiya, AN, Basanez, G, Schubert, U, Henklein, P, Yewdell, JW, Zimmerberg, J

J Virol 2004
Participants
Input
Output
Participant Of
hasEvent
Event Information
Go Biological Process
induction of host immune response by virus (0046730)
Disease
Name Identifier Synonyms
influenza 8469 Influenza with other manifestations (disorder), Influenza with other manifestations NOS (disorder), flu, Influenza with other manifestations, Influenza with non-respiratory manifestation (disorder), influenza with non-respiratory manifestation
Authored
Gillespie, ME  (2013-11-18)
Reviewed
Gale M, Jr  (2004-05-12)
Created
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