Binding of NS1 to poly(A)-binding protein II (PABII)

Stable Identifier
R-HSA-168883
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Influenza A virus
Compartment
Locations in the PathwayBrowser
General
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The influenza virus non-structural protein 1 (NS1) binds to the host cell's poly(A)-binding protein II (PABII) thus preventing PABII from properly extending the poly-A tail of pre-mRNA within the host cell nucleus. These pre-mRNAs are then prevented from exiting the nucleus.

Literature References
PubMed ID Title Journal Year
10205180 Influenza A virus NS1 protein targets poly(A)-binding protein II of the cellular 3'-end processing machinery

Chen, Z, Li, Y, Krug, RM

EMBO J 1999
Participants
Participant Of
Event Information
Disease
Name Identifier Synonyms
influenza 8469 Influenza with other manifestations (disorder), Influenza with other manifestations NOS (disorder), flu, Influenza with other manifestations, Influenza with non-respiratory manifestation (disorder), influenza with non-respiratory manifestation
Authored
Reviewed
Created
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