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Binding of NS1 to poly(A)-binding protein II (PABII)
Stable Identifier
R-HSA-168883
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Influenza A virus
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
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Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
Influenza Infection (Homo sapiens)
NS1 Mediated Effects on Host Pathways (Homo sapiens)
Inhibition of Host mRNA Processing and RNA Silencing (Homo sapiens)
Binding of NS1 to poly(A)-binding protein II (PABII) (Homo sapiens)
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The influenza virus non-structural protein 1 (NS1) binds to the host cell's poly(A)-binding protein II (PABII) thus preventing PABII from properly extending the poly-A tail of pre-mRNA within the host cell nucleus. These pre-mRNAs are then prevented from exiting the nucleus.
Literature References
PubMed ID
Title
Journal
Year
10205180
Influenza A virus NS1 protein targets poly(A)-binding protein II of the cellular 3'-end processing machinery
Chen, Z
,
Krug, RM
,
Li, Y
EMBO J
1999
Participants
Input
NS1 Homodimer [nucleoplasm]
(Influenza A virus)
PABPN1 [nucleoplasm]
(Homo sapiens)
Output
NS1:PAB II Complex [nucleoplasm]
(Homo sapiens)
Participates
as an event of
Inhibition of Host mRNA Processing and RNA Silencing (Homo sapiens)
Event Information
Go Biological Process
suppression by virus of host mRNA processing (0039524)
Disease
Name
Identifier
Synonyms
influenza
DOID:8469
Influenza with other manifestations (disorder), Influenza with other manifestations NOS (disorder), flu, Influenza with other manifestations, Influenza with non-respiratory manifestation (disorder), influenza with non-respiratory manifestation
Authored
Gillespie, ME (2013-11-18)
Reviewed
Gale M, Jr (2004-05-12)
Created
© 2024
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