Reactome | Binding of NS1 to dsRNA

Binding of NS1 to dsRNA

Stable Identifier

R-HSA-168891

Type

Reaction

Species

Homo sapiens

Related Species

Influenza A virus

Compartment

cytosol

Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Influenza Infection (Homo sapiens)
    - Host Interactions with Influenza Factors (Homo sapiens)
      - NS1 Mediated Effects on Host Pathways (Homo sapiens)
        
        Inhibition of Interferon Synthesis (Homo sapiens)
        
        Inhibition of IFN-beta (Homo sapiens)
        
        Binding of NS1 to dsRNA (Homo sapiens)
        
        Inhibition of PKR (Homo sapiens)
        
        Binding of NS1 to dsRNA (Homo sapiens)

Summation

The ability of viral non-structural protein 1 (NS1) to sequester dsRNA is believed to be one of the primary mechanisms by which NS1 prevents activation of downstream anti-viral signaling pathways.

Literature References

14645582

A recombinant influenza A virus expressing an RNA-binding-defective NS1 protein induces high levels of beta interferon and is attenuated in mice

J Virol

2003

Participants

input

output

NS1:viral dsRNA Complex [cytosol] (Influenza A virus)

Participant Of

hasEvent

Disease

Diseases

influenza

8469

Influenza with other manifestations (disorder), Influenza with other manifestations NOS (disorder), flu, Influenza with other manifestations, Influenza with non-respiratory manifestation (disorder), influenza with non-respiratory manifestation