Reactome | Binding of NS1 to dsRNA

Binding of NS1 to dsRNA

Stable Identifier

R-HSA-168891

Type

Reaction

Species

Homo sapiens

Related Species

Influenza A virus

Compartment

cytosol

Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Influenza Infection (Homo sapiens)
    - Host Interactions with Influenza Factors (Homo sapiens)
      - NS1 Mediated Effects on Host Pathways (Homo sapiens)
        
        Inhibition of Interferon Synthesis (Homo sapiens)
        
        Inhibition of IFN-beta (Homo sapiens)
        
        Binding of NS1 to dsRNA (Homo sapiens)
        
        Inhibition of PKR (Homo sapiens)
        
        Binding of NS1 to dsRNA (Homo sapiens)

Summation

The ability of viral non-structural protein 1 (NS1) to sequester dsRNA is believed to be one of the primary mechanisms by which NS1 prevents activation of downstream anti-viral signaling pathways.

Literature References

PubMed ID	Title	Journal	Year
14645582	A recombinant influenza A virus expressing an RNA-binding-defective NS1 protein induces high levels of beta interferon and is attenuated in mice Donelan, NR, Basler, CF, Garcia-Sastre, A	J Virol	2003

Participants

Input

Output

NS1:viral dsRNA Complex [cytosol] (Influenza A virus)

Participant Of

hasEvent

Event Information

Go Biological Process

evasion or tolerance by virus of host immune response (0030683)

Disease

Name	Identifier	Synonyms
influenza	8469	Influenza with other manifestations (disorder), Influenza with other manifestations NOS (disorder), flu, Influenza with other manifestations, Influenza with non-respiratory manifestation (disorder), influenza with non-respiratory manifestation

Authored

Gillespie, ME (2013-11-18)

Reviewed

Gale M, Jr (2004-05-13)