Binding of NS1 to PKR

Stable Identifier
R-HSA-168896
Type
Reaction
Species
Homo sapiens
Related Species
Influenza A virus
Compartment
Locations in the PathwayBrowser
Summation

Influenza virus inhibits the host double-stranded-RNA-activated protein kinase (PKR) by a couple of mechanisms. One of those steps is the direct binding of PKR by the viral non-structural protein NS1.

Literature References
PubMed ID Title Journal Year
10846107 Influenza virus NS1 protein counteracts PKR-mediated inhibition of replication J. Virol. 2000
Participants
Participant Of
Event Information
Disease
Name Identifier Synonyms
influenza 8469 Influenza with other manifestations (disorder), Influenza with other manifestations NOS (disorder), flu, Influenza with other manifestations, Influenza with non-respiratory manifestation (disorder), influenza with non-respiratory manifestation