Upon binding viral dsRNA, Probable ATP-dependent RNA helicase DDX58 (DDX58, RIG-I, RIG-1) and Interferon-induced helicase C domain-containing protein 1 (IFIH1, MDA5) recruit the downstream signal transducer Mitochondrial antiviral-signaling protein (MAVS, IPS-1). This mitochondria-bound adaptor has an N-terminal CARD-like domain (CLD) which associates with the CARD regions of DDX58 and IFIH1 to mediate induction of interferons.
Seth, RB, Sun, L, Ea, CK, Chen, ZJ
Xu, LG, Wang, YY, Han, KJ, Li, LY, Zhai, Z, Shu, HB
Potter, JA, Randall, RE, Taylor, GL
Kawai, T, Takahashi, K, Sato, S, Coban, C, Kumar, H, Kato, H, Ishii, KJ, Takeuchi, O
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