viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58 bind MAVS

Stable Identifier
R-HSA-168909
Type
Reaction
Species
Homo sapiens
Related Species
Rotavirus, Influenza A virus, Hepatitis C Virus, Measles virus
Compartment
mitochondrial outer membrane, cytosol
Synonyms
RIG-I/MDA5 interacts with IPS-1
Locations in the PathwayBrowser
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Summation

Upon binding viral dsRNA, Probable ATP-dependent RNA helicase DDX58 (DDX58, RIG-I, RIG-1) and Interferon-induced helicase C domain-containing protein 1 (IFIH1, MDA5) recruit the downstream signal transducer Mitochondrial antiviral-signaling protein (MAVS, IPS-1). This mitochondria-bound adaptor has an N-terminal CARD-like domain (CLD) which associates with the CARD regions of DDX58 and IFIH1 to mediate induction of interferons.

Literature References
PubMed ID Title Journal Year
16125763 Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3

Seth, RB, Sun, L, Ea, CK, Chen, ZJ

Cell 2005
16153868 VISA is an adapter protein required for virus-triggered IFN-beta signaling

Xu, LG, Wang, YY, Han, KJ, Li, LY, Zhai, Z, Shu, HB

Mol Cell 2005
18307765 Crystal structure of human IPS-1/MAVS/VISA/Cardif caspase activation recruitment domain

Potter, JA, Randall, RE, Taylor, GL

BMC Struct Biol 2008
16127453 IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction

Kawai, T, Takahashi, K, Sato, S, Coban, C, Kumar, H, Kato, H, Ishii, KJ, Takeuchi, O

Nat Immunol 2005
Participants
Input
Output
Participant Of
hasEvent
This entity is regulated by
Negative Regulation
Orthologous Events
Activated MDA5 binds IPS-1 (Gallus gallus)
Authored
Garapati, P V  (2010-08-02)
Reviewed
Kawai, T  (2010-10-30)
Akira, S  (2010-10-30)