Reactome | viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58 bind MAVS

viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58 bind MAVS

Stable Identifier

R-HSA-168909

Type

Reaction

Species

Homo sapiens

Related Species

Rotavirus, Influenza A virus, Hepatitis C Virus, Measles virus

Compartment

mitochondrial outer membrane, cytosol

Synonyms

RIG-I/MDA5 interacts with IPS-1

Locations in the PathwayBrowser

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Summation

Upon binding viral dsRNA, Probable ATP-dependent RNA helicase DDX58 (DDX58, RIG-I, RIG-1) and Interferon-induced helicase C domain-containing protein 1 (IFIH1, MDA5) recruit the downstream signal transducer Mitochondrial antiviral-signaling protein (MAVS, IPS-1). This mitochondria-bound adaptor has an N-terminal CARD-like domain (CLD) which associates with the CARD regions of DDX58 and IFIH1 to mediate induction of interferons.

Literature References

PubMed ID	Title	Journal	Year
16125763	Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3	Cell	2005
16153868	VISA is an adapter protein required for virus-triggered IFN-beta signaling	Mol Cell	2005
18307765	Crystal structure of human IPS-1/MAVS/VISA/Cardif caspase activation recruitment domain	BMC Struct Biol	2008
16127453	IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction	Nat Immunol	2005

Participants

Input

Output

viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)

Participant Of

hasEvent

DDX58/IFIH1-mediated induction of interferon-alpha/beta

This entity is regulated by

Negative Regulation

Orthologous Events

Activated MDA5 binds IPS-1 (Gallus gallus)