Reactome: A Curated Pathway Database

viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58 bind MAVS

Stable Identifier
R-HSA-168909
Type
Reaction
Species
Homo sapiens
Related Species
Hepatitis C Virus, Rotavirus, Influenza A virus, Measles virus
Compartment
Synonyms
RIG-I/MDA5 interacts with IPS-1
Locations in the PathwayBrowser
Summation

Upon binding viral dsRNA, Probable ATP-dependent RNA helicase DDX58 (DDX58, RIG-I, RIG-1) and Interferon-induced helicase C domain-containing protein 1 (IFIH1, MDA5) recruit the downstream signal transducer Mitochondrial antiviral-signaling protein (MAVS, IPS-1). This mitochondria-bound adaptor has an N-terminal CARD-like domain (CLD) which associates with the CARD regions of DDX58 and IFIH1 to mediate induction of interferons.

Literature References
Participants
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Orthologous Events