Reactome | DDX58 [cytosol]

DDX58

Stable Identifier

R-HSA-168917

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

RIG-I

Locations in the PathwayBrowser

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Literature References

PubMed ID	Title	Journal	Year
15208624	The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses	Nat Immunol	2004

External Reference Information

External Reference

UniProt:O95786 DDX58

Gene Names

DDX58

Chain

chain:1-925

Reference Genes

BioGPS Gene:23586 DDX58

COSMIC (genes):DDX58 DDX58

CTD Gene:23586 DDX58

dbSNP Gene:23586 DDX58

ENSEMBL:ENSG00000107201 DDX58

HGNC:19102 DDX58

KEGG Gene (Homo sapiens):hsa:23586 DDX58

Monarch:23586 DDX58

NCBI Gene:23586 DDX58

OMIM:609631 DDX58

UCSC:O95786 DDX58

Reference Transcript

RefSeq:NM_014314.3 DDX58

Other Identifiers

0005220180

11733149_a_at

11755819_a_at

11756330_a_at

12643

17093090

218943_s_at

222793_at

23586

2LWD

2LWE

2QFB

2QFD

2RMJ

2YKG

3203088

3203089

3203090

3203091

3203092

3203093

3203095

3203096

3203097

3203098

3203101

3203103

3203104

3203105

3203106

3203107

3203108

3203109

3203110

3203111

3203113

3203115

3203121

3203122

3LRN

3LRR

3NCU

3OG8

3ZD6

3ZD7

47193

4AY2

4BPB

4NQK

4ON9

4P4H

59215_at

5E3H

5F98

5F9F

5F9H

76098_r_at

77749_at

8160559

A_23_P20814

A_33_P3418170

AAD19826

AAI32787

AAI36611

AF038963

AL137608

AL161783

AL353671

BC132786

BC136610

BX647917

CAB012643

CAB70840

CAH71251

CAH72600

CAI46068

CCDS6526

CH471071

DDX58

DDX58-202

EAW58548

ENSG00000107201

ENSP00000369213

ENST00000379883

EntrezGene:23586

g7657515_3p_a_at

GE54334

GO:0000166

GO:0002230

GO:0002376

GO:0003674

GO:0003676

GO:0003677

GO:0003690

GO:0003723

GO:0003725

GO:0003727

GO:0004386

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005623

GO:0005737

GO:0005829

GO:0005856

GO:0005886

GO:0005923

GO:0006464

GO:0006605

GO:0006810

GO:0006913

GO:0006950

GO:0007165

GO:0008150

GO:0008270

GO:0009058

GO:0009597

GO:0009615

GO:0010628

GO:0015629

GO:0016020

GO:0016032

GO:0016579

GO:0016787

GO:0019899

GO:0030054

GO:0030334

GO:0031625

GO:0032480

GO:0032587

GO:0032725

GO:0032727

GO:0032728

GO:0032755

GO:0032757

GO:0034344

GO:0034641

GO:0035549

GO:0039528

GO:0039529

GO:0040011

GO:0042802

GO:0042993

GO:0042995

GO:0043167

GO:0043226

GO:0043330

GO:0044403

GO:0045087

GO:0045944

GO:0046872

GO:0048870

GO:0051091

GO:0051607

GO:0060760

GO:0071360

GO:1902741

GO:1904469

GO:2000778

HGNC:19102

HPA047193

Hs.145612.0.S2_3p_at

ILMN_1797001

IPR001650

IPR011545

IPR014001

IPR021673

IPR027417

IPR031964

MIM:609631

MIM:616298

NM_014314

NP_055129

PF00270

PF00271

PF11648

PF16739

PH_hs_0025667

SM00487

SM00490

TC09000999.hg

uc003zra.4

UPI000013C841

Participant Of

hasCandidate

ISG15 targets [cytosol]

hasMember

input

output

CYLD mediated deubiquitination of DDX58 (RIG-I)

hasComponent

Other forms of this molecule

PolyUb-DDX58 [cytosol]

K48polyUb-DDX58 [cytosol]

K63polyUb-DDX58 [cytosol]

Inferred To

DDX58 [cytosol] (Bos taurus)

DDX58 [cytosol] (Caenorhabditis elegans)

DDX58 [cytosol] (Canis familiaris)

DDX58 [cytosol] (Dictyostelium discoideum)

DDX58 [cytosol] (Mus musculus)

DDX58 [cytosol] (Rattus norvegicus)

DDX58 [cytosol] (Saccharomyces cerevisiae)

DDX58 [cytosol] (Sus scrofa)

DDX58 [cytosol] (Taeniopygia guttata)

DDX58 [cytosol] (Xenopus tropicalis)

Homologues of DDX58 [cytosol] (Caenorhabditis elegans)

Homologues of DDX58 [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_055129.2

GeneCards

O95786

DOCK Blaster

5F9F, 3OG8, 4AY2, 5F9H, 3LRN, 2QFD, 5E3H, 3LRR, 4BPB, 3ZD7, 4P4H, 3ZD6, 3NCU, 2QFB, 4NQK, 5F98, 4ON9, 2YKG

PRO

O95786

BRENDA (Homo sapiens)

3.6.4.13

Orphanet

23141

HMDB Protein

HMDBP11688

PDB

4P4H, 5F9F, 4BPB, 4AY2, 2RMJ, 4NQK, 5F9H, 5F98, 2QFD, 3OG8, 2LWE, 3LRR, 4ON9, 3NCU, 3ZD7, 2YKG, 2QFB, 2LWD, 5E3H, 3ZD6, 3LRN

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q7Z434 MAVS	2	K48polyUb-MAVS [mitochondrial outer membrane] (R-HSA-983463) MAVS [mitochondrial outer membrane] (R-HSA-913730)	0.926	13
UniProt:Q7Z2W4-2 ZC3HAV1			0.61	4
UniProt:Q14258 TRIM25	2	TRIM25 [cytosol] (R-HSA-918186) TRIM25 [nucleoplasm] (R-HSA-5653667)	0.602	4
UniProt:F1BA49 F1BA49			0.576	5
UniProt:Q920D5 CASPC			0.557	4
UniProt:Q6IUF9 Z			0.544	3
UniProt:Q6UY71 Z			0.544	3
UniProt:Q6IVU5 Z			0.544	3
UniProt:O75569 PRKRA	1	PRKRA [cytosol] (R-HSA-2399897)	0.524	2
UniProt:O95786 DDX58	5	PolyUb-DDX58 [cytosol] (R-HSA-6782770) PolyUb-DDX58 [cytosol] (R-HSA-6782999) K48polyUb-DDX58 [cytosol] (R-HSA-3080568) DDX58 [cytosol] (R-HSA-168917) K63polyUb-DDX58 [cytosol] (R-HSA-918191)	0.524	2
UniProt:Q9NQC7 CYLD	2	p-S418-CYLD [cytosol] (R-HSA-5212667) CYLD [cytosol] (R-HSA-741420)	0.524	2
UniProt:P04487 RNB			0.524	4
UniProt:Q7Z2W4 ZC3HAV1	2	p-ZC3HAV1-BRAF fusion [cytosol] (R-HSA-6802557) ZC3HAV1-BRAF fusion [cytosol] (R-HSA-6802506)	0.524	3
UniProt:Q96S55 WRIP1			0.499	2