Viral dsRNA:TLR3 recruits TRIF (TICAM1)

Stable Identifier
R-HSA-168929
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Influenza A virus, Rotavirus, Hepatitis B virus, Hepatitis C Virus, Human herpesvirus 1
Compartment
endosome membrane, cytosol
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Viral dsRNA:TLR3 recruits TRIF (TICAM1)
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TIR-domain-containing adaptor inducing interferon-beta (TRIF or TICAM1) was shown to play an essential role in TLR3 signaling. All poly(I:C)-induced pathways leading to NFkB and IRF3 activation were abolished in TRIF-/- mice [Yamamoto et al. 2003].

Literature References
PubMed ID Title Journal Year
12855817 Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway

Sugiyama, M, Takeuchi, O, Sanjo, H, Hoshino, K, Takeda, K, Okabe, M, Sato, S, Yamamoto, M, Kaisho, T, Hemmi, H

Science 2003
14517278 LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters

Fitzgerald, KA, Rowe, DC, Latz, E, Barnes, BJ, Golenbock, DT, Pitha-Rowe, PM, Monks, BG, Caffrey, DR, Visintin, A

J Exp Med 2003
12539043 TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta induction

Matsumoto, M, Oshiumi, H, Funami, K, Akazawa, T, Seya, T

Nat Immunol 2003
Participants
Input
Output
Participates
as an event of
Orthologous Events
viral dsRNA : TRL3 recruits TICAM1 (Gallus gallus)
Authored
Luo, F  (2005-11-10)
Reviewed
Fitzgerald, KA  (2012-11-13)
Gay, NJ  (2006-04-24)
Created
de Bono, B  (2005-11-22)
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