Viral dsRNA:TLR3 recruits TRIF (TICAM1)

Stable Identifier
R-HSA-168929
Type
Reaction
Species
Homo sapiens
Related Species
Rotavirus, Influenza A virus, Hepatitis B virus, Hepatitis C Virus, Human herpesvirus 1
Compartment
cytosol, endosome membrane
Locations in the PathwayBrowser
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Summation

TIR-domain-containing adaptor inducing interferon-beta (TRIF or TICAM1) was shown to play an essential role in TLR3 signaling. All poly(I:C)-induced pathways leading to NFkB and IRF3 activation were abolished in TRIF-/- mice [Yamamoto et al. 2003].

Literature References
PubMed ID Title Journal Year
14517278 LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters

Fitzgerald, KA, Rowe, DC, Barnes, BJ, Caffrey, DR, Visintin, A, Latz, E, Monks, BG, Pitha-Rowe, PM, Golenbock, DT

J Exp Med 2003
12855817 Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway

Yamamoto, M, Sato, S, Hemmi, H, Hoshino, K, Kaisho, T, Sanjo, H, Takeuchi, O, Sugiyama, M, Okabe, M, Takeda, K

Science 2003
12539043 TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta induction

Oshiumi, H, Matsumoto, M, Funami, K, Akazawa, T, Seya, T

Nat Immunol 2003
Participants
Input
Output
Participant Of
hasEvent
Orthologous Events
viral dsRNA : TRL3 recruits TICAM1 (Gallus gallus)
Authored
Luo, F  (2005-11-10)
Reviewed
Gay, NJ  (2006-04-24)
Fitzgerald, KA  (2012-11-13)