TIR-domain-containing adaptor inducing interferon-beta (TRIF or TICAM1) was shown to play an essential role in TLR3 signaling. All poly(I:C)-induced pathways leading to NFkB and IRF3 activation were abolished in TRIF-/- mice [Yamamoto et al. 2003].
Sugiyama, M, Takeuchi, O, Sanjo, H, Hoshino, K, Takeda, K, Okabe, M, Sato, S, Yamamoto, M, Kaisho, T, Hemmi, H
Fitzgerald, KA, Rowe, DC, Latz, E, Barnes, BJ, Golenbock, DT, Pitha-Rowe, PM, Monks, BG, Caffrey, DR, Visintin, A
Matsumoto, M, Oshiumi, H, Funami, K, Akazawa, T, Seya, T
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