Dimerization of phosphorylated IRF3/IRF7

Stable Identifier
R-HSA-168933
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Phosphorylation results in IRF-3 dimerization and removal of an autoinhibitory structure to allow interaction with the coactivators CBP/p300.

Literature References
PubMed ID Title Journal Year
12692549 IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway

Fitzgerald, KA, McWhirter, SM, Faia, KL, Rowe, DC, Latz, E, Golenbock, DT, Coyle, AJ, Liao, SM, Maniatis, T

Nat Immunol 2003
14555995 X-ray crystal structure of IRF-3 and its functional implications

Takahasi, K, Suzuki, NN, Horiuchi, M, Mori, M, Suhara, W, Okabe, Y, Fukuhara, Y, Terasawa, H, Akira, S, Fujita, T, Inagaki, F

Nat Struct Biol 2003
Participants
Participant Of
Orthologous Events
Authored
Reviewed