Reactome: A Curated Pathway Database

viral dsRNA binds DDX58

Stable Identifier
R-HSA-168935
Type
Reaction
Species
Homo sapiens
Related Species
Hepatitis C Virus, Rotavirus, Influenza A virus
Compartment
Synonyms
dsRNA binds to RIG-I
Locations in the PathwayBrowser
Summation

Probable ATP-dependent RNA helicase DDX58 (DDX58, RIG-I, RIG-1) has two caspase recruitment domains (CARD) in its N-terminus, a DExD/H helicase domain with an ATP binding motif in the middle and a repressor domain (RD) in the C-terminus. In the absence of appropriate stimulation, DDX58 is in a 'closed' conformation in which the repressor domain phyically interacts with the helicase domain masking CARD. Upon viral infection, the free triphosphate structure at the 5' end of viral RNAs activates DDX58 by binding to its RNA helicase domain. This provokes a change in DDX58 conformation exposing the CARD leading to DDX58 dimerization, allowing it to interact with Mitochondrial antiviral-signaling protein (MAVS, IPS-1).

Literature References
Participants
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