Ligand binds to TLR10

Stable Identifier
R-HSA-168947
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Ligand binds to TLR10
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Microbal stimulation was shown to alter mRNA expression of TLR10 in human granulocytes, monocytes[Zarember KA and Godowski P 2002] and B cells[Bourke ED et al 2003]. However the natural ligand of TLR10 remains unknown.

Literature References
PubMed ID Title Journal Year
15728506 Human TLR10 is a functional receptor, expressed by B cells and plasmacytoid dendritic cells, which activates gene transcription through MyD88

Hasan, U, Chaffois, C, Gaillard, C, Saulnier, V, Merck, E, Tancredi, S, Guiet, C, Briere, F, Vlach, J, Lebecque, S, Trinchieri, G, Bates, EE

J Immunol 2005
Participants
Input
Output
Participant Of
hasEvent
Orthologous Events
Ligand binds to TLR10 (Bos taurus)
Ligand binds to TLR10 (Canis familiaris)
Ligand binds to TLR10 (Danio rerio)
Ligand binds to TLR10 (Drosophila melanogaster)
Ligand binds to TLR10 (Gallus gallus)
Ligand binds to TLR10 (Plasmodium falciparum)
Ligand binds to TLR10 (Sus scrofa)
Ligand binds to TLR10 (Xenopus tropicalis)
Authored
Luo, F  (2005-11-10)
Reviewed
Gale M, Jr  (2006-10-31)
Gillespie, ME  (2011-02-10)
Created
de Bono, B  (2005-11-22)
Cite Us!