Reactome | Ligand binds to TLR10

Ligand binds to TLR10

Stable Identifier

R-HSA-168947

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

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Microbal stimulation was shown to alter mRNA expression of TLR10 in human granulocytes, monocytes[Zarember KA and Godowski P 2002] and B cells[Bourke ED et al 2003]. However the natural ligand of TLR10 remains unknown.

Literature References

PubMed ID	Title	Journal	Year
15728506	Human TLR10 is a functional receptor, expressed by B cells and plasmacytoid dendritic cells, which activates gene transcription through MyD88 Hasan, U, Chaffois, C, Gaillard, C, Saulnier, V, Merck, E, Tancredi, S, Guiet, C, Briere, F, Vlach, J, Lebecque, S, Trinchieri, G, Bates, EE	J Immunol	2005