TLR6:TLR2 is recruited to ligand:CD14:CD36

Stable Identifier
R-HSA-168950
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Chlamydia trachomatis
Compartment
extracellular region, plasma membrane
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
TLR6:TLR2 is recruited to ligand:CD14:CD36
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

TLR2 - in combination with TLR6 - plays a major role in recognizing lipoteichoic acid (LTA) and peptidoglycan wall products from Gram-positive bacteria, as well as Mycobacterial diacylated lipopeptides.

Literature References
PubMed ID Title Journal Year
10364168 Peptidoglycan- and lipoteichoic acid-induced cell activation is mediated by toll-like receptor 2

Schwandner, R, Dziarski, R, Wesche, H, Rothe, M, Kirschning, CJ

J Biol Chem 1999
10426996 Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2

Aliprantis, AO, Yang, RB, Mark, MR, Suggett, S, Devaux, B, Radolf, JD, Klimpel, GR, Godowski, P, Zychlinsky, A

Science 1999
10490993 Human toll-like receptors mediate cellular activation by Mycobacterium tuberculosis

Means, TK, Wang, S, Lien, E, Yoshimura, A, Golenbock, DT, Fenton, MJ

J Immunol 1999
14977973 Relationship between structures and biological activities of mycoplasmal diacylated lipopeptides and their recognition by toll-like receptors 2 and 6

Okusawa, T, Fujita, M, Nakamura, J, Into, T, Yasuda, M, Yoshimura, A, Hara, Y, Hasebe, A, Golenbock, DT, Morita, M, Kuroki, Y, Ogawa, T, Shibata, K

Infect Immun 2004
10549626 Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components

Takeuchi, O, Hoshino, K, Kawai, T, Sanjo, H, Takada, H, Ogawa, T, Takeda, K, Akira, S

Immunity 1999
11123271 Cutting edge: functional interactions between toll-like receptor (TLR) 2 and TLR1 or TLR6 in response to phenol-soluble modulin

Hajjar, AM, O'Mahony, DS, Ozinsky, A, Underhill, DM, Aderem, A, Klebanoff, SJ, Wilson, CB

J Immunol 2001
18178856 The proinflammatory cytokine response to Chlamydia trachomatis elementary bodies in human macrophages is partly mediated by a lipoprotein, the macrophage infectivity potentiator, through TLR2/TLR1/TLR6 and CD14

Bas, S, Neff, L, Vuillet, M, Spenato, U, Seya, T, Matsumoto, M, Gabay, C

J. Immunol. 2008
Participants
Input
Output
Participant Of
hasEvent
Authored
D'Eustachio, P  (2006-04-19)
Gay, NJ  (2006-04-19)
Gale M, Jr  (2006-04-19)
Zwaginga, JJ  (2006-04-19)
Reviewed
D'Eustachio, P  (2006-07-04)
Gillespie, ME  (2010-11-30)
Created
de Bono, B  (2005-11-22)